Methadone Pills and a Benzo

[Beefy]

Ok, I'm beginning to think there is something really wrong and different about the pills vs liquid. I was given 170pills for a trip i had to go to from my clinic. I can survive a couple of days without it, so since i'm traveling, and with old friends again, I've decided to have some night for fun. But i've also been thinking of not going overboard. My tolerance to methadone liquid can go as high as 250mg before my eyes get pinned.
But for some reason, I've taken 350mg worth of pills while at the same time taking half a stick, and nothing much happened. I took the stick first and the pills later. I'm not really asking what method i should take them so i'll really feel the syngergistic effect of both. But tonight i've decided to take another 350mg worth of pills, and might take a stick and a half. I'm around people, in case anything goes wrong.
I guess my question is, Should i stop if i'm not getting anything @ 350 with a stick? or have there been people in here who have gone up to 400, 500 or 600mg of methadone? And what do you think the big difference is between the pills and the liquid. I know one of them is that the pills take longer to hit your body cause they have to dissolve.

Thanks

 

[Swimmingdancer]

Generally we try to avoid comparisons between different forms or brands because it can get into the realm of speculation and personal opinion. However I do know that some of the so-called "inactive" ingredients in certain pills can decrease the bioavailability. I posted some scientific research showing this in another thread. I've had a very hard time getting doctors to actually believe there could be a difference though, as this info about the binders/fillers is really not well known and people on methadone are viewed with suspicion and not trusted. Not sure what kind of pills you have or what is in them though. There could also be a number of other factors that influence the effects of methadone that are unrelated to what formulation you are taking.

350mg seems like a hell of a lot of methadone to me! Especially to be combining with benzos. Where I live no one is prescribed doses that high. My concern is what if they are just taking longer to dissolve and hit you later but all at once? And what is your tolerance to benzos? What benzo are you taking - is it Xanax? - and how many mg are in a "stick"?

I do hope you understand the serious risks of taking opioids and benzos together recreationally? That is the number one cause of fatal overdoses. I would NOT just keep upping your doses. You've already taken 100mg more methadone than you normally do. Please just stop now, don't add any more benzos or methadone. A big danger with doing this, even if you are not alone, is that you can seem fine, go to bed, and then just not wake up. I've known people who died this way. And note that the respiratory depression lasts longer than the high (so not feeling very high doesn't necessarily mean you can't die).

 

[mrflowers00]

thats a lot of methadone i take 450mg of oxycodone for and fair high and wouldn't go over 150mg of methadone and i guess by stick you mean xanax bar i wouldn't even consider taking xanax with that large a dose of methadone

 

[phatass]

the only difference i noticed between the gelltabs i got wit powder compared to the liquid is that the liquid hits you quicker, you get sliightly more of a come-up

 

[rhun]

Methadone and benzos are incredibly dangerous, it's really not advisable that you mix them. Especially since you're doing a higher dose of methadone than you're used to. The ONLY way to do them together is if you have a really really big tolerance to both and you're doing smaller doses of both than you're used to. But even then there is risk. You have to ask yourself, is it worth risking your life?

At my methadone clinic they do random UAs monthly and the main reason is not even to check if you're still using but to make sure you're not taking any benzos. I know people in the program who still use heroin or other opiates and they don't get kicked out. They can't advance and get take homes but they don't kick them out. But if you test positive for benzos you're out. They do a 15 day taper and kick you out.

The reason it because a few years back in my county dozens of people were dying because they were mixing benzos with methadone. And a kid I went to school with died last month from mixing benzos and Oxycontin. People die all the time from mixing benzos.

 

[helium-4]

The methadone pills in the US dissolve almost instantly where the binders and fillers hardly will effect the rate of absorption. However, people constantly do not take in account that the high BA of oral administration can be drastically decreased by a number of physiological factors (content in your stomach, pH, etc) that have nothing to do with the different formulation. In general yes liquids will have a slightly faster come up time, but with methadone, the time to peak plasma concentrations when taken orally wouldn't be different by really much of a significance from liquid to pill dosage. This is assuming the liquid concentration/amount is the amount you are told to be consuming and is equal to the amount you consume via the pills.

Also taking more methadone when you are taking 80+mg really doesn't make much of a difference in any sort of high according to most individuals experience talked about on here and from what I've heard from people in real life (the main difference is how long it sustains them, the reduction of cravings, and reduced effect in attempt to get high on other opioids).

Even with a methadone tolerance and a benzo tolerance individuals die from the benzo + methadone combo. The statistics are easily found using google. Its not something to be taken lightly. If you are taking more methadone than you are used to, and continuing to consume higher doses day after day, the concentration of methadone in your system builds up, raising the chance that the benzos will push you over the edge till you die from respiratory depression. Be smart.

 

[Swimmingdancer]

The methadone pills in the US dissolve almost instantly where the binders and fillers hardly will effect the rate of absorption.

I have no idea what specifically was in the pills the OP took and did not mean to encourage discussion about whether certain forms of methadone are more effective/stronger than others, or get everyone talking about what form they prefer or whether they think one is different, etc. As I said, we try to discourage this kind of speculative discussion. I was just mentioning one possibility I did know about that can happen with certain ingredients and was at least based on scientitific fact and not just speculation - but I don't know whether it is applicable to these pills though, or whether even if it was it could actually alter the BA that much.

I also DO NOT want anyone to start assuming that all liquid methadone is stronger than all methadone pills. Or that they should take more when taking the pills or anything like that.

However, people constantly do not take in account that the high BA of oral administration can be drastically decreased by a number of physiological factors (content in your stomach, pH, etc) that have nothing to do with the different formulation. In general yes liquids will have a slightly faster come up time, but with methadone, the time to peak plasma concentrations when taken orally wouldn't be different by really much of a significance from liquid to pill dosage. This is assuming the liquid concentration/amount is the amount you are told to be consuming and is equal to the amount you consume via the pills.

Also taking more methadone when you are taking 80+mg really doesn't make much of a difference in any sort of high according to most individuals experience talked about on here and from what I've heard from people in real life (the main difference is how long it sustains them, the reduction of cravings, and reduced effect in attempt to get high on other opioids).

^These are all very good points.

I am concerned about the OP - Beefy can you please let us know if you're ok?

 

[Beefy]

Blah! It was not worth trying. I guess i should just stay on my 90mg a day dose. And not try to get any "nod" or anything from it by adding xanax. that time i just fell asleep. the xanax makes me go to sleep almost all the times i try it if i'm home. another time that same week i took 350mg of 'done by itself and still nothing. They were legit pills. I got them from my clinic. They were the 10mg ones straight from an unopened bottle. They gave me 170 pills.
But yes, I've been incredibly lucky while mixing methadone and benzos. So i should just call it quits. I don't want to have a bad day with it. Cause the amounts i've been experimenting with, a bad day would probably be my last day. My tolerance to xanax is not incredibly low or high. Half a stick will make me go to sleep if i take at night. But i ahve an incredibly high tolerance to opiates. But the synergistic effects is what i have to watch out for.