Opioids Methadone onset during sleep?

[celestialvibez]

Hi I'm currently in MMT, dosing at 40mg a day. I work night shift so I take my dose around 7am and fall asleep no later then 10am and I definitely feel the methadone before I sleep, but when I wake up usually around 3pm I do not feel any of the effects. On the weekends though when I stay awake after I dose, I feel the methadone buzz up to 12 hours after ingestion. So I am wondering in general why sleeping would cause this effect on me. Thanks

 

[ish675]

Poppy Pod Tea is the same way with me, I get a good 12 hour buzz off PPT. If I go to sleep I always wake up sober though. I feel like it may be because the doses that we take are somewhat low and the high may be "lost" in the groggy feeling as you wake up. Not a technical answer but I hope it helps!

 

[sl1p609]

this sounds good for me to know i'm on 17.75 and 15mgs mdone currently, sometimes i have a hard time sleeping because i take my dose the 1st thing in the morning.

there is OTC T'3s here and sometimes i mix them. Today i feel its ok just staying with this dose.

Has anyone ever crushed up the Mdone and put it in a capsule to IR release.. .?

I'll come back for more

 

[Znegative]

^well, I've never heard if an extended release version of Methadone, but if you want a faster onset I recomend rectal administration. The BA is slightly lower the inset and duration make up for it IMO.

 

[Swimmingdancer]

Hi I'm currently in MMT, dosing at 40mg a day. I work night shift so I take my dose around 7am and fall asleep no later then 10am and I definitely feel the methadone before I sleep, but when I wake up usually around 3pm I do not feel any of the effects. On the weekends though when I stay awake after I dose, I feel the methadone buzz up to 12 hours after ingestion. So I am wondering in general why sleeping would cause this effect on me. Thanks

This happens to me too. I find that when I take methadone in the morning the effects last longer than when I take it before bed. I am guessing it may have to do with metabolization, perhaps the metabolization is slower when we are awake.

there is OTC T'3s here and sometimes i mix them

Do you actually feel much from the codeine? Methadone decreases the effects of codeine. You get less of the good effects but you still get all the side effects. Personally I feel like for me taking Tylenol 3's also shortens the effects of the methadone but I don't have any science to base that on (whereas I do know the science behind the methadone decreasing the codeine).

Has anyone ever crushed up the Mdone and put it in a capsule to IR release.. .?

That wouldn't make any difference as methadone is already IR. If you crush it up it might make it absorb slightly faster as it doesn't have to dissolve in your stomach as much, but it doesn't make a big difference and doesn't change the actual effects of the methadone.