Opioids Methadone is outdated, an idea to treat fentanyl addiction with fentanyl

[Them Witches]

@Ddeeee

You just shared some very helpful knowledge and wisdom. I hope the OP transitions into his better self like all of us are trying to do.

I would guess 98% of all the members here are trying to better themselves and are meant to be here.

As a suggestion adding spaces in paragraphs makes it easy to read. Many of us cannot see worth damn.

 

[Ddeeee]

@Ddeeee

You just shared some very helpful knowledge and wisdom. I hope the OP transitions into his better self like all of us.

I would guess 98% of all the members here are trying to better themselves and are meant to be here.

As a suggestion adding spaces in paragraphs makes it easy to read. Many of us cannot see worth damn.

Bro thankyou for replying for 1 and 2 I must apologize I had a few drinks earlier and smoked a bit of suprisingly good 1to1 a few hourse ago and I decided to force myself to stay awake which wasnt very smart and yeah that post is a bit all over the place but if you think its bad now then you should of seen it before I "fixed" it bro lol

so true as well your right about everyone well (nearly) everyone wants to better themselves you have made me feel a bit selfish now actually because I was talking like im the only one who wants to improve themselves and not giving anyone else attention my bad for that its been a very very very long time since I was on this site I actually didnt intend to return but a certain member was telling lies about me so I decided to go from a lurker back to a poster just to call him out on his lie,.

Sadly I now think he was just trying to get a reaction out of me and it looks like he did but oh well im getting to old to be bitter im just looking foward from now on not backwards by the way Witches did you know me on my main account(ganjcat) back in the past or is this the first time? just wondering anyway.

Im gonna go kip as I can barely keep my eyes open it took everything just to write the last few posts lol but im a soldier so i just keep soldiering on.

much love my brother.

 

[Them Witches]

you have made me feel a bit selfish now

That was not the intent nor was not the focus of my post. I was trying to say that we all belong here for one reason or another and many of the members are in or have been in a hole losing everything due to character defects not being managed. Most of us are allergic to drugs and beak out in felonies & misdemeanors. Many of us have set boundaries with ourselves we would never cross and ended up crossing them, just leading to guilt & shame.

Not every insult deserves a response. I would ignore whoever is trying to start problems with you. If the drugs don't kill you, the people will.

Your all good in my book and I hope all goes well for you.

 

[Keif' Richards]

I don't want to be a dick here guys, but I'm pretty sure this has to be moved to a different area. This seems less like a thread with an actual objective than a rant about the current situation. I will say that I totally agree with you. There should have been more done for these people. I'm using the past-tense because I do not believe that this "thing" is ever going to be done. The people who are out there addicted to Fentanyl right now are either going to get clean (extremely hard), die or become to infirmed to hustle out on the street. I know at least 3 people who I've seen go from ambulatory, to cane, to wheelchair to dead in wheelchair as a result of nothing other than Fentanyl/Xylazine.

If anything was going to be done to save the generation, it would have had to have been done several years ago. I'm not saying we can't still do positive things. I want to bring attention to the fact that society has collectively agreed that it's okay for a lot of these people to die. We knew that the situation was huge. We knew it would likely take a revolutionary approach to stem the tide. Instead, we really did nothing but decriminalize drug usage, allowing people greater freedom to use poisonous drugs. I believe much of this was calculated, either consciously or somewhat consciously by those that are involved with these policies.

Drug addicts are unsightly. They bother people. There are a huge drain on the resources of a city. Motel rooms, doctor's appointments, ambulance call outs, violent incidents. For people disconnected in any way from these people, it becomes more and more attractive to imagine if these people weren't around causing problems and taking money. I believe that enacting a true Heroin/Hydromorphone or similar program throughout all of North America could help prevent the next generation from dying. We already know that people in Canada regularly sell their Hydromorphone tablets to buy Fentanyl. Any junkie 20 years ago offered a supply of Hydromorphone like this would consider it a gift from god. Now Fentanyl has made it pretty much useless for those already dependent on stronger shit.

 

[4DQSAR]

Well, compound 1c in theory would fully substitute for fentanyl.

But I'm pretty sure it wouldn't substitute for carfentanil.

Is there someing that would substitute for carfentanil?

Yes there is. TH-030418.

TH-030418: a potent long-acting opioid analgesic with low dependence liability - Naunyn-Schmiedeberg's Archives of Pharmacology

Numerous efforts have been made on the chemical modification of opioid compounds, with the ultimate goal of developing new opioid analgesics that is highly potent and low/non-addictive. In a search for such compounds, TH-030418...

link.springer.com

 

[barberX]

I've never been sure why Fentanyl patches have never been used for opioid addiction. Especially since a patch lasts 3 days, rather than having to take methadone or buprenorphine daily.

I have experience with all. Fentanyl causes mood disregulation over time. Methadone stabilizes mood which is needed in addicts.

 

[emkee_reinvented]

Way back when they used to treat heroin addiction with heroin. Was common practice in the UK once upon a time until cost and politics got in the way. There are still a few people kicking about with legacy diamorphine prescriptions.

Still some country s that practice it, just on site use mostly.
NL, UK, Swiss edit on NL for addict harm reduction.
In UK hear say Granny s get it after Hip-replacement.

 

[Them Witches]

I hope that the FDA/DEA does not push making 7-OH a schedule 1 drug. 7-OH would a great MAT add on and a great chronic pain & chronic pain syndrome add on. Bypassing all stops and directly to jail without a proper investigation of what are the possibilities of this new active ingredient (obviously not new which should make it more interesting). Even with medical trials with cancer pain, non-cancer pain, and chronic pain syndrome pain, I believe as society as a whole and especially the medical community there is more to 7-OH than "bad drug" "must kill bug immediately" attitudes.

From my chronic pain syndrome patient view, 7-OH helps with pain and in general makes me feel good. It would be a great add on for these reasons : 1) If adding it, I would not have to increase my daily narcotic dosages. 2) It makes my mornings better and I am up cleaning house, dishes, making to-do lists, and in general quality of life has improved the days I take it. I can still get those things mentioned done, it is 7-OH has helped. I think Busbar is helpful to chronic pain syndrome patients. 3) 7-OH provides a "needed" rotation opioid. 4) 7-OH does not produce some of the unwanted effects from traditional opiates/opioids. This makes post-op surgery easier for some patients.

Not everyone likes Methadone, Suboxone, so MAT would have a new option. 7-OH would also be new tools for MAT when tapering off Methadone or Subs. They might find out a "rapid taper" off higher dosages of Methadone or Subs. Once down to a stable dosage, the 7-OH can be tapered back as well. they just have to tried to find out.

If they push immediately for banning and schedule 1 classification about all mentioned would not take place and never will. I cannot believe big pharma is not sharpening their hooks on this subject. Offering a 7-OH IR and 7-OH ER would be an effective tool for pain management, MAT, and other forms of treatment. Plus poppies do not have to produced.

 

[whereismylife]

Honestly after experiencing how well SR-17018 can work myself (and reading the countless other success stories I've come across online) it really seems like this substance is miles ahead of every other option when it comes to detoxing off of opiates.

IMO the only thing that even compares would be an iboga detox, but unfortunately that's not something that can be done safely at home due to risk of heart failure, and doing it safely through an actual iboga resort costs thousands of dollars.

SR-17018 is comparatively cheap and by all accounts relatively safe. Unlike methadone/Suboxone it actually gets you clean off of all opiates instead of simply replacing one opiate with another that's potentially even more difficult to get off of.

 

[Korn3x]

Ain't no way I'm reading all that. Fentanyl is part of the problem. Honestly the government should bring heroin back, schedule it properly, rename it something different to avoid the stigma, but I guess the roa is fucked. Reformulate a version that you can orally ingest. Actually it should be legal to purchase in certain areas. Maybe within 20-50 years we could get progress like this.
If you stick with it methadone can have high success and it's cheap. Aim to get stable on low doses to minimize risk of QT prolongation. Recreational marijuana for depression, need access to legal dispensaries with good strain selection and dab selection to figure out what works. We need to get these drug testing laws reformed fast. Some states have made progress, others still catching up and waiting on recreational status.

 

[Them Witches]

Honestly the government should bring heroin back, schedule it properly, rename it something different to avoid the stigma,

Yes indeed... Your words are soothing to my soul.

It would be a great breakthru pain medication and a good opioid for rotation.

A extended release version would be useful for pain management for a primary and instant release for breakthru pain.

Post-op acute pain is another great reason.

I think once the FDA/DEA files drugs into the schedule 1 black-hole it is hard to retrieve it. They are having success with marijuana yet it hits about all the checklist questions for safer and less addictive. If 7-OH is not utilized by big pharma, they must really hate lining their pockets with money. We all know this is not the case.

Back to heroin#4, yes Bayer had the heat back in the 1890's-1920's. Honestly at this point making most drugs legal is the answer - remove cartels, china's death grip, reduce crime, remove desire for fentanyl, tranq-dope, nitazines, etc. If I was voted in as president on Friday, I would be assassinated come Sunday.