Route of administration impacts my use of methadone. I'm not sure if theres science to this like water solivity but I prefer the "burn baby burn disco inferno" method
This is the case for methadone imo. I’m on a rectally administered dose right now as we speak.
Snorting also boosts the effect, speed of onset, and intensity imo but I would not recommend snorting it because the powder is very dusty and easily gets into the lungs and is very caustic and hurts the lungs. I’ve gotten bad lung pain from snorting methadone pills
IV use is too dangerous and not worth it in terms of the effects,
Sublingual can be good if done right, I recently started a thread on sublingual methadone if you’d like to check out my reports on trying that. However the best ROA for this particular drug is rectal imo.