The only way to prove it is to sit on 380mg/day for a year and just STOP. Let's see how many people survive that one.
While on that 380mg/day dose I was hit with narcan by a vindictive paramedic. I was strapped to a gurney, cussing him out, and the motherfucker did it. Within a minute I started involuntarily shitting myself. I've never been so cold in my life. Always wanted to find the guy and cut his thumbs off (so he can't use a syringe ever again), fortunately I don't remember the guy. I had taken a ton of phenobarbital and had passed out so someone called 911. I was fine, awake and talking, but yes, pretty aggressive in my refusal of medical services, but they forced me.
Talk about pain. Imagine the painful feeling of sticking your hand in a bucket of ice and holding it in there. That's how my whole body felt.