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Opioids Methadone brands potency - Mallinckrodt vs Roxanne?

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My nephew was on the Mallinckrodt methadone with imprint "M 57-71" for over a decade. He went into SEVERE withdrawal on one occasion when the pharmacy switched to Roxanne methadone. Since I am a pharmacologist, he called me, at the time I told him that it was probably just a placebo-effect, he assured me it WAS NOT..... Since he had been on Pain Management for over seven years at that time, he had a "Stash" of the Mallinckrodt methadone, asking me to come visit him. I did, I can attest he was in SEVERE withdrawal, and he told me that the sweats, pain, huge pupils and body aches, all went away when he would simply take 40mg of the Mallinckrodt methadone.

He was on an Rx of 9x 10Mg/Day. So he asked me to document that the Roxanne pills were in fact the 10mg Methadone tabs, and that the Pharmacy did not dispense the wrong pills. I did, they were in fact the Roxanne 10mg methadone tabs. I told him to take half-Roxanne and half Mallinckrodt methadone tabs because the pharmacy would not exchange them. He got through that month with a large toll on his 'stash-pills', and always requested Mallinckrodt methadone 10mg tabs thereafter. He has since passed away from an overdose, but had gone to a MMT center after his Doctor sold the Pain Practice. The MMT had him on 220mg/day and he was completely miserable prior to his passing, saying that "Liquid Methadone is NOT REAL Methadone". He left that written in his suicide note.

Very SAD!

In the decade-plus of him on Mallinckrodt methadone, he had told me that he took an average of only 70mg/Day, hence accounting for his STASH pills. Yet whilst going to a MMT clinic, even on a dose of 220mg/Day he reported that he was in constant pain and felt horrible depression, so bad it led to suicide.... Something everyone on this forum might consider, just how powerful this drug IS, and the consequences !!!

I have since done an enormous amount of research as to WHY he had these horrible life experiences at the young age of 36. He is now dead, an opiate addict for over twenty years of his life. I'm currently writing a paper to submit to medical journals and the MMT practitioners.

My view; THERE IS A DIFFERENCE between various "Methadone", I hope to someday soon expose exactly what that might be.... Be very careful with this drug!!! PLEASE !!!
 
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So I've been taking the Roxanne manufactured methadone (with the 54 / 142 imprint) whenever I've been doing methadone for recreation lately; but now I've come into possession of some Mallinckrodt methadones (rectangular, Xanax bar looking ones with imprint M 57 71). Both kinds are 10mg. My friend told me these Mallinckrodt ones are a good deal stronger than the Roxanne, and he recommended lessening or even halving my typical dose accordingly. What do you guys think, is there any difference between the two brands in terms of potency or is it pretty negligible?

(I know some argue this kind of thing is purely placebo effect, but I've switched brands of klonopin with no particular expectation and noted that the new brand was very noticeably stronger than the old, for example)..

Just to clarify, here's links to the two:
http://www.drugs.com/imprints/54-142-544.html (Roxanne)
http://www.drugs.com/imprints/m-57-71-5107.html (Mallinckrodt)


I have taken the roxanne 54-142 10mgs for a couple years now and just had to switch pharmacies as the one was going to for years would not fill my 360ct any more. I went to their competitor and they filled it using the Malli's 57 71. I took my usual two about 3pm yesterday and as of right now I have not been asleep yet. I am wide awake and feel pretty pain-less. I say they work much better. I have a unusually high tolerance to all meds or drugs and these are good. Normally I take either 20mg 3x's a day but had gone to 30mgs 3x's a day. I also take 30mg Addie's and as for giving you an extra kick, if you like to speed, two of the 57 71 two 30mg Addie's in the morning and go to work. 6-8 hours of go. Didn't take it that way yesterday, just took the M boxes, they took 2 hrs to kick in but when they did, holy crap. I took my last Xanax, 1mg, 30mg trazadone and 3 ty pm's and still couldnt sleep. Its now 4am, had my coffee and about 30 min ago my morning meds. Gonna go get ready for work. I will let ya know how it was this evening.
 
About the recreationality of methadone; I think it can be euphoric in low doses for people with no opiate tolerance or low tolerance. It's also the most dangerous for people like that...
 
you know we could figure this out once and for all by simply having someone on here do a double blind test... you can do this yourself very simply... put one of each into a cup... have someone reach in and put one in your mouth (without you looking) and leave the other one in the cup but also don't look... then report back on the effectiveness of the pill before looking at what is left in the cup...
 
I have to say that I noticed this too and I thought it was ridiculous because I know that logically its supposed to be the same..however with generics there IS a certain margin of error, I believe (IIRC) that they must conaint at or above 92% of the active ingredient stated so you never know there could be.

I gotta second the Malli's tho. My pharmacy switched to the round ones and I was like yall need to order me those rectangles again.

When I first used methadone recreationally yeaaaaaars ago , because the first couple times you use it you DO definitely get high, I noticed the difference more.

The logical rational side of me says "fuck that there aint no differnce" but my experience tells me that the mallinckrodts are definintely superior.
 
^Word, Malli > all.

I'm closing this thread as it now (and has been) in violation of the current OD guidelines for quite some time now, since we don't allow brand discussion. But Mallinckrodt hands down makes the best methadone. So how's that for mixed messages?
 
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