Once stable on high dose Methadone 80-100mg daily for months and months……it will block the euphoric rush from other short acting opioids, such as oral Oxy, i.v. Heroin & Dilaudid, etc
Actually, 30-40mg Methadone starts to saturate the mu-opioid receptors in the CNS so you don’t really feel other opioids. That’s why Methadone is so successful….due to its looooong ass half life and by occupying/binding to a significant amount of the mu-receptors ……someone shooting H or Dilaudid won’t feel Sh!t because it has nowhere to bind to in the CNS
I was on Methadone 70mg when I took four(4) OxyContin 80mg tablets (original PF formulation) stamped CDN / 80, pulverized them into fine powder, diluted in water and drawn up in a 1cc 30gauge insulin syringe and I banged it and felt ABSOLUTELY NOTHING lol….not a thing. All the mu-opioid receptors in my CNS were occupied by Methadone
I’ve been on Methadone 80mg now for 10-15 years due to medical condition/chronic pain and wouldn’t even bother taking any other opioid, except more Methadone lol. I have in my fireproof safe, Hydromorph-Contin 9mg capsules, Dilaudid 2mg IR tablets, Oxycodone 5mg tablets (Oxy-IR 5mg) and many other highly desirable controlled substances (all legally prescribed to me, Vyvanse, Adderall, Biphentin (Ritalin), Valium 10mg, Klonopin 0.5mg) plus Ketamine hcl crystals, LSD-25 / 100ug tabs, Psilocybin mushrooms, Coca-Cola, etc
Canada is great for easy access/tolerance for Cannabis, LSD, psilocybin, DMT, Ketamine, even MDMA (questionable purity) all others are Pharma/lab grade like our Ketamine and the cleanest LSD-25
Damn I love LSD ….the most beautiful drug ever …love it’s dopaminergic properties over psilocybin and long duration
Being at the cottage in summer surrounded by mother nature and clean shimmering lake illuminated by the blazing Sun

….drinking ice cold beers with nice music playing, few awesome close friends, bbq, bonfire at night looking at the sky full of diamonds shinning bright lol
Even public places like the Royal Botanical Garden with my GF, on a hit of Acid lol, shades on, dressed fresh & clean, bottle of pop with 3.oz of Jin in it, having a cigarette with the warm sun caressing my face lol….touching beautiful flowers with fat fuzzy bumble bees hovering around everywhere, landing on my arm, no panic, just a childlike amazement and curiousity. Talking with random people with a smile on my face, happy & giddy at times, exploring the rock garden with trickling flowing streams, animals everywhere, birds singing, an outdoor oasis …..like heaven actually….Adam & Eve is what I got from that trip at the RBG ….was like paradise