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Meth+ritalin/ephedrine. Experiences/Neurochemisty.

Q

quale

Bluelighter
Joined
Nov 25, 2001
Messages
1,064
I remember answer a post the other day about taking amphetamines with epedrine. At the time I suggested that while I didn't think it was a fun idea it should probably potentiate the meth a small amount (by competing for the CYP2D^ pathway). Thinking about it a little more made me realize that I am not really sure what happens.
It seems that meth works alot like E. A significant part of its effect comes from entering the neuron and realesing vesicular dopamine and reversing the reuptake transporter. In order to do these things one would expect, just like E, that the reuptake transporter can't be blocked. Taking E with an SSRI certainly kills the E effect.
So the major effects from ritalin and ephedra seem to come from just blocking reuptake. It seems in theory this might prevent the meth from acting. So does anyone have any experience combinging either of these substances with high doses of meth?
Although cocaine might be a little more complicated in its action has anyone noticed a decrease in effects from high doses of meth after consuming a reasonable amount of coke?
Any thoughts on what is going on here would be appreciated as well.
 
Interesting as only about 4 days ago I took 90mg of ephedra in conjuction with smoked methamphetamine (around 60mg). It was strange and jittery, but it would be a cheap and effective potentiator. It lasted far longer, and may have made for a more smooth comedown, especially from smoking.
 
Since dopamine is much more plentiful, could there be plenty of axons for the meth to effect despite the ephedrine? i.e. youd have to have a large saturation of ephedrine to block the meth. Also, ephedrine and meth prob work in slight different areas of the brain.
 
cocaine + methamphetamine, same syringe, is extremely crazy. I noticed no diminished effects, possibly synergistic effects, a very rough high though.
 
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