Metabolic pathways of the 2c-x series

[egor]

I recently stumbeled on some good info on the metabolism of the 2c series while looking for info for DS after his little unpleasantness. The thread it was posted in was closed, so here it is.
Please post any other info you may have on the subject so we can try to compile a good thurough consensus on the total metabolic process of the family.


http://www.ncbi.nlm.nih.gov/entrez/...uids=17276685&query_hl=13&itool=pubmed_docsum
Mao and Cyp2d6 are both involved in the metabolism of many of the series

http://www.ncbi.nlm.nih.gov/entrez/...uids=16600701&query_hl=13&itool=pubmed_docsum
O-demethylation, N-acetylation hydroxylation of the ethyl side chain at C2' or at C1' followed by oxidation at C1' to the corresponding ketone

http://www.ncbi.nlm.nih.gov/entrez/...uids=15827969&query_hl=13&itool=pubmed_docsum
gc/ms detection of blood metabolites of the 2c-x series

I will post more later when I have some time

 

[egor]

Feel free to move to ADD if you feel I will get better responses there
Here is some more good info

http://www.ncbi.nlm.nih.gov/entrez/...uids=16325192&query_hl=19&itool=pubmed_docsum

 

[Xorkoth]

--> Moved to ADD.

 

[lux]

Sulfurous Samadhi (2c-t-2 and 2c-t-7):
http://www.erowid.org/chemicals/2ct7/article1/

I'll have more soon, and will love to see anyone else's suggestions. Any articles on the pharmacology of the 2C's would interest me very much.

 

[dimensiontripping]

I recently stumbeled on some good info on the metabolism of the 2c series while looking for info for DS after his little unpleasantness. The thread it was posted in was closed, so here it is.
Please post any other info you may have on the subject so we can try to compile a good thurough consensus on the total metabolic process of the family.


http://www.ncbi.nlm.nih.gov/entrez/...uids=17276685&query_hl=13&itool=pubmed_docsum
Mao and Cyp2d6 are both involved in the metabolism of many of the series

http://www.ncbi.nlm.nih.gov/entrez/...uids=16600701&query_hl=13&itool=pubmed_docsum
O-demethylation, N-acetylation hydroxylation of the ethyl side chain at C2' or at C1' followed by oxidation at C1' to the corresponding ketone

http://www.ncbi.nlm.nih.gov/entrez/...uids=15827969&query_hl=13&itool=pubmed_docsum
gc/ms detection of blood metabolites of the 2c-x series

I will post more later when I have some time

since it is about 5mcg/l there would be no way for it to show up as an amphetamine as the cut off is exponentially bigger, right?

 

[otb01]

Well, I could contribute that the metabolic attack on the 2C series is at the 4 site but everyone knows that. 2 and 5 are likely also spots for the attack.