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Mescaline/Psilocybin tolerance

M

mecha0man

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Jan 9, 2010
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Hello. I have a question about the cross tolerance of these two substances. I searched around and could only find a limited amount of information and the information I did find was split about 50/50 in opinion on whether or not these two substances were cross tolerant. On Friday night I dosed about 350-400 mg's of mescaline and tonight (Monday) I want to eat 3 grams of mushrooms. Can anyone tell me from experience whether or not this is a good idea, or if I should hold out on eating the mushrooms.
 
It varies a lot from person to person how much cross tolerance there is between different psychedelics. In my experience, I get just as much cross tolerance taking one psychedelic and then a different one as I would taking the same psychedelic both times. If I don't give myself a good 5-7 days between trips, the peak is usually noticeably less intense. I wouldn't say it's an outright waste to trip on mesc on a Friday and then shrooms the following Monday, but if you want to get the most bang for your buck I'd wait a couple more days.
 
I think it would work fine. Tryptamines are cross-tolerant with each other but mescaline isn't a tryptamine.
 
Well, they'd be some cross tolerance. Just not as much as if you took the same thing a few days apart.
 
The chemical structures are completely different with these two compounds. I do notice a cross tolerance between phens and trypts. Lets say I were to take a 20mg 2c-i dose, the next day I could take a tryptamine with diminished effects of about 1/5th as compared if you were to take another phenethylamine the second day instead of switching it our for a tryptamine, then 1/3 potency is lost. These numbers are going to drastically change from person to person.
 
Trust me, there is a huge cross-tolerance between mesc and 4-AcO-DMT/4-HO-MET (with both of these being related to mushrooms, particuarly 4-AcO-DMT). I hadn't taken either of those research chems for about 2 weeks and had just been using mescaline and MDXX - yet I ended up having a ++ with a total of 44mg between those two chemicals 48 hours after last using mescaline though the euphoria was amazing, there were only some CEVs and very little OEVs. Save your shrooms or you'll waste them.
 
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