• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Phenethylamines Mescaline + MDMA?

T

Themailman

Bluelighter
Joined
Feb 24, 2026
Messages
102
I was able to score 500mg of synthetic mescaline and will be trying it out soon. It's the only psychedelic I've never tried. I am a little intimidated by its duration. I also have a ton of molly on hand.

I loved snorting 12mg of 2cb while coming up on molly, made for one of the best rolls ever.

I just feel like I might get bored of just plain mescaline for so many hours.

Anyone tried mescaline and MDMA?
 
No idea about the combination but imo mescaline is pretty whole as is, very emotionally opening (in my opinion in a similar way as the entactogens) and as such any additions pretty unnecessary, particularly if it is your first time.
 
Hi, I never used mescaline, but I have used MDMA, 2CB, and may other psychedelics, alone and in combos.

MDMA and a psychedelic phenethylamine has always been a good combo for me, but given the duration of Mescaline I would think that, depending on how you feel when coming down from MDMA, it may not be a great idea to dose high on the MDMA.
Keep MDMA on the low, 120 to 200mg in total, and you'll avoid coming down too hard while still tripping on Mescaline.

On top of that, IME you have about 90 minutes to take a second dose of a psychedelic on top of the first and feel it in a nice way, after that it's basically a waste of drugs.

For the first time using a drug I'd recommend you only take that drug so you can get an idea of how it is on its own.
 
I’ve used methallylescaline than 5 mapb two hours later. Good combo, emotionally opening, which 5 mapb being , is more so

Ime and opinion, not as many mgs are needed for both, if combined and or used a couple years apart
 
I recommend the mescaline on its own, and I would argue that if you get bored during your trip, that means you didn't adequately prepare. Mescaline is a serious psychedelic but is more active on the senses and emotions than it is mentally active compared with LSD and tryptamines.

Keep in mind that the trip goes through many phases. You might think you've reached a peak, and then a whole new layer of effects set in. It takes at last 4 hours to reach maximum effects with little decline until T+9 hours or so. Large doses tend to last longer than 12 hours. I strongly recommend dosing within a few hours of waking.

My best trips have involved dosing around 11 or noon with access to an outdoor setting, in nature, in a place that I can safely walk around and explore during the peak. It's often better to be stationary for the first 3 hours or so when nausea and body effects are likely to be strongest, but the peak can have a lot of restlessness and energy. This timing allows for a truly epic sunset to enjoyed, and then the effects begin to diminish gradually after dark. The late part of the trip tends to be less energetic and can be very introspective. It's good to have "chill" activities available like sitting around a fire having a heart-to-heart with a close friend, or lounging and listening to music, or maybe watching a movie. Typically I'm not hungry until almost 10 hours in, and I often don't sleep until well past the 12 hour duration, in the early morning hours if I started at noon. It's good to have at least two days afterwards to recover before having to return to "normal" life.
 
^ I agree with the above especially if it's your first time. I'm not really sure how these two interact because I've never taken them together. But in general MDMA mixes well with most every psychedelic I've taken it with. But given the long duration of this one combined with the fact it's a phenethylamine I'd be worried about the MDMA being wasted by being overshadowed by the mescaline. You'd be trying to shoehorn a short duration drug into a long duration experience. Any benefits at all will probably be negated by the effects of the mescaline. Further more, I have a hard rule I stick to of always trying a new substance by itself the first time so I can get more familiar with its effects on me. I never mixed MDMA with LSD until I'd done both separately many times.

Concerning long duration phenethylamines: They can be tiring but in practice this isn't a big deal as long as you plan for it. As the person above said plan to start early in the day and try to time things so you'll be in a good mood at either sunset or sunrise. In other words, plan to take the substance a few hours before sunrise or in the middle of the day (noon-ish) so you'll be somewhere near the peak by sunset. Give yourself at least a day or two for recovery where you can sleep all you want without being disturbed.

I would highly suggest planning to be outside for the majority of this trip in a place where you're comfortable and not likely to be bothered. For me this would be at home since I have a small plot of private land. If that's not the case for you then maybe plan on doing it on a camping and/or hiking trip where there won't be many other people around. Any nice safe outdoor location where you have room to roam around and a good view of the sky.

If I were you I'd save the MDMA for another time. If you're dead set on doing them together maybe have the mescaline on day 1 and the MDMA on day 2. But you'll probably be feeling pretty tired and ready for a nice long sleep by the time the mescaline has run its course. The MDMA would probably be better saved for a special occasion on another day. I'm not sure if cross-tolerance comes into play with MDMA and mescaline as I've never had both avaiable at the same time. I suspect they do and you'd be looking at a diminished roll if you consumed it on day 2. So swapping them around might be a better option (MDMA day 1, mescaline day 2). The MDMA first would certainly be less tiring going into day 2 than doing it the other way around.

If you're deadset on mixing them my friend's old advice reigns true: "There is really no wrong way to do it" (meaning: mixing MDMA with psychedelic and the timing of dosing either/or (e.g. candy flipping)).

Again though I'd really suggest taking the mescaline alone for your first time. You should find it's wonky enough on its own to be interesting.
 
Thanks for the advice. You guys are probably right. I've been using too much molly anyways.

I will probably combine a bit of 2cb on the come up or comedown and then maybe add some nitrous

I'm a real polyaddict if you can't tell heh
 
Not very good combo, these substances do not go well together, kinda work slightly against each other, and mescaline tends to overshadow MDMA.
 
Its a perfect combo brother. If I ever get the chance to do it again I will take it. I would not do too much mdma though, mostly because mescaline is like this holy cacti medicine thats been used since the beginning of time to tripp balls. The aztecs used to have completely pitch black rooms in the royal palace where leaders would drink mescaline tea and just tripp the f*ck out.

in a sense it would probably be more chill if you skipped the mdma and just did more 2cb. Its like combining two cultures, one ancient and one by the modern man Shulgin.

Oh fuck it, why not take all three, thats what an aztec would do if he/she had all three available to them.

🤘
 
Last time I took mescaline, around 8 hours in, I had an intense rushing body high and intense emotionality. It was a bit like MDMA times 1000 or something, it was just so intense. After taking mescaline and other good phenethylamines, I'm not even really interested in MDMA anymore.
 
Themailman said:
I was able to score 500mg of synthetic mescaline and will be trying it out soon. It's the only psychedelic I've never tried. I am a little intimidated by its duration. I also have a ton of molly on hand.

I loved snorting 12mg of 2cb while coming up on molly, made for one of the best rolls ever.

I just feel like I might get bored of just plain mescaline for so many hours.

Anyone tried mescaline and MDMA?
Click to expand...
I did that once, drank a good dose of San Pedro juice.
Probably around a foot long worth.

Was at a 2day psytrance festival, about 3h after the Pedro i took 2 X pills.
Def should only have done 1, i got really messed up.
Had a good time but it was intense.
 
This
doubledog said:
Not very good combo, these substances do not go well together, kinda work slightly against each other, and mescaline tends to overshadow MDMA.
Click to expand...


I am surprised not many people have tried this combo. I've combo'd mescaline with most other common substances and aside from LSD, I don't think it combines well with most things

I took 330mg of Mesc HCL waited about 45 min and took 50mg of MDA. The trip wasn't bad per se, but the mescaline does tend to overpower the latter. I found myself asking why I'd even taken the MDA.

Also taken it with 2C-B, mushrooms, and DMT.
 
Mescaline is a good psychedelic to start with (Even though its like the only one I havent had) Taken alot of "Similar structure chems" but never the OG -- Pretty mellow, lasts along time, prepares you for the body load of future psychs if you so choose
 
notsmokeymcpot42088 said:
Mescaline is a good psychedelic to start with (Even though its like the only one I havent had) Taken alot of "Similar structure chems" but never the OG -- Pretty mellow, lasts along time, prepares you for the body load of future psychs if you so choose
Click to expand...
While I second this, I did recently hear from a friend who has a fair amount of psychedelic experience, totally freaking out on 400mg of mescaline alone. Took him a few days to calm down, and told me he had a noticeable afterglow for weeks.
 
If you've tried all the psychedelics, then why are you initimidated by the length? It's just a bit longer than LSD, and no longer than DOM or DOC. Other DOx last longer as well. BOH-2c-b lasts a while, as does 2c-ef and 2c-p.

Even so, mescaline can be very gentle compared to other psychs. I liken it to riding a lazy, long gentle wave.
 
First time mescaline at 500mg you will want for nothing and be grateful for the experience afterwards.

Don't get greedy. Mescaline is the tits.

If you do have to mix it mix it with acid, but it's worth trying on its own and would be a waste not to if you only have 500mg.

Didgital said:
've combo'd mescaline with most other common substances and aside from LSD, I don't think it combines well with most things
Click to expand...
It combines really, really well with LSD. Unbelievably well. More than the sum of its parts.
 
Last edited:
You must log in or register to reply here.
Top