Merits of using both cimetidine (Tagamet) AND Grapefruit Juice to enhance benzos

[murph29]

I have some valiums im trying to get the most out of...Should I use tagamet AND white grapefruit juice TOGETHER before ingesting the valium or should I pick one or the other? thanks!!

basically, does WGFJ potentiate valium better or does cimetidine (tagamet)

 

[NeighborhoodThreat]

In my experience, Tagamet does a better job and gives you more consistent results. For some people WGFJ works better, though.

 

[effie]

Both inhibit CYP-3A4 which is one of the main enzyme responsible for metabolising diazepam (cimetidine also inhibits other CYP-450 enzymes including CYP-2D6 which metabolises some opioids) - I am not sure whether combining the two noticeably potentiates diazepam more than just taking one or the other, maybe someone else knows that :D

Diazepam has active metabolites so that confuses matters somewhat..

edit: ninja'd by NT :D

 

[murph29]

well i took 400mg tagamet 45 min prior to taking 50 mg valium and didnt really notice anything at all....so idk....i had taken 40mg valium 2 hours before with no potentiators....could this be the reason??

 

[murph29]

basically i'd just like to know whether combining WGFJ with tagamet 45min - 1 hour before will make any better pronounced effects or if i should just to the white GFJ for now?? or take 600mg tagamet alone?

 

[mgrady3]

i'd stick to 400mg tagamet

You ay have to do the experiment yourself and see if WGFJ and Tagamet give increased effects.
One problem you may be encountering is that Diazepam already has a long halflife - tagamet will make that longer. IMO the 'potentiation' just extends the lifetime of the drug in your system. It doesn't make you feel it any stronger. I'm a bit biased because I only use it with clonazepam and I only use it at night to help me sleep.

SO i'd say its avery subtle thing to be able to detect in the first place, considering recreational use. If you are suffering form anxiety you may easily be able to detect a lengthened period in which you feel somewhat better but over all the tagamet or WGFJ is not going to make the feelings from the diazeoam stronger, only last longer.

I don' see any inhernet problem with using both tagamet and WGJF other than you don't want to fuck with your CYP's too much. I wouldn't make this a daily ha bit. But once in a while should be fine as long as you are aware of which enzymes are being inhibited so if you need to take any other medicine besides the diazepam you must check first that there is no adverse reaction to the specific CYP's you've been inhibiting