Mephedrone - What do we know?

[nuke]

Yeah.

 

[Rickyo]

OK, so whilst it might be a lot more neurotoxic, it is less potent so that cancels a lot of the damaging effect out?

 

[nuke]

No, I mean, not really, it's just less potent of a neurotoxin by weight. But the ratio of 5HT release to NE/DA release isn't necessarily the be all and end all of neurotoxicity. For instance napthylaminopropane isn't neurotoxic but releases some 5HT along DA and NE.

 

[crazynate:]]

yea we're all guinea pigs who do this... I stopped for a minute like a month ago cause I was using it everyday for a week straight and I never slept and my heart didn't, and still doesnt, feel right... Probably the best drug I've ever done, but you have to accept the risk to do it

 

[PrettyKitty]

Another Meph thread woow .

Mephedrone caused me very realistic auditory and visual hallucinations after consuming 2+ grams/binge.

I have a prolonguedd irregular heartbeat.

Weakness/shortness of breath.

Poor circulation and color.

Visual abnormalities (vibrating peripherals)

etc.etc.etc.

 

[Rickyo]

Another Meph thread woow .

Mephedrone caused me very realistic auditory and visual hallucinations after consuming 2+ grams/binge.

I have a prolonguedd irregular heartbeat.

Weakness/shortness of breath.

Poor circulation and color.

Visual abnormalities (vibrating peripherals)

etc.etc.etc.

Lasting problems, possibly permanent?

 

[Xtc <3]

I worry about this stuff and should stay away from it... but its sooo damn good.
Gives me really intense pains occasionally for a day or two after in my heart area to the point where im crippled in the fetal position.
Apart from that though I feel fine and dandy after it (and can sleep )

I have been using methylone as an alternative lately as I believed it was safer than mephedrone, but as a previous post on this thread suggested:

I'd be more concerned about methylone than this, personally. Methylone is likely to result in a 3,4-hydroxy-methcathinone derivative. Dopamine analogue metabolites aren't good for you at all. Big bad idea.

So should I scrap the whole methylone is a safer alternative idea and just stick to good old meph as its cheaper and better imo.

 

[dread]

Well fuck, even if methylone producese a 3,4-hydroxy-metabolite it will still be safer than mephedrone. At least I've never heard anyone's limbs turning blue from methylone.

If you want an even safer alternative why not try a MDAI + MDPV combo. I've heard good things about it...

 

[MeDieViL]

I worry about this stuff and should stay away from it... but its sooo damn good.
Gives me really intense pains occasionally for a day or two after in my heart area to the point where im crippled in the fetal position.
Apart from that though I feel fine and dandy after it (and can sleep )

I have been using methylone as an alternative lately as I believed it was safer than mephedrone, but as a previous post on this thread suggested:



So should I scrap the whole methylone is a safer alternative idea and just stick to good old meph as its cheaper and better imo.

Methylone is definatly safer then meph, no question about it man..

I can second the MDPV-MDAI combo.

 

[hoptis]

Can I relate an anecdote that isn't completely off-topic, perhaps one of you fine minds in here can tell me what this means.

I went pretty hard with ecstasy for some years, usually with very good quality/strong pills, but after a few years of fairly regular (weekly) use, I started developing severe nausea after taking them. Usually nausea would be brought on by a cigarette, but would continue after smoking finished... it tends to persist for up to two days after taking ecstasy (and after having slept) and at times was so bad I pretty much stopped taking pills because of it.

The timing of the onset of this nausea leads me to believe it could be related to a period when I started taking 5-HTP regularly as a pre and post-load. If I take 5-HTP now after taking MDMA, the nausea is so unbearable I cannot leave the house. I can take 5-HTP at other times when I haven't taken MDMA and don't feel sick, if anything I feel quite happy the following day.

The thing is, post-methylone, I also notice this nausea-effect but nowhere near as bad as compared to post-MDMA.

Post-mephedrone, this nausea isn't there at all, nor after taking meth or LSD.

After trying methylone, I assumed that the nausea was related to serotonin release. If that's the case, then it's also my assumption that mephedrone is significantly less serotonergic than MDMA or methylone.

PS. I would like to state in advance, to spare the embarrassment of the ADD mods that my level of technical understanding of drugs is not representative of this forum or it's staff.

 

[Jamshyd]

MDPV feels highly selective for dopamine but there must be a saturation point... because with higher and repeated doses it becomes very empathogenic and entactogenic. Saturation of dopamine receptors > crossover to Sert?

Once again, a prime example of the ever-elusive power to "feel" certain neurotransmitters that some people seem to possess but which I never quite understood.

It is amazing how far the bullshit that big-pharma feeds you can go, ie DA = stim, 5-HT=Love...etc.

 

[pofacedhoe]

well once you overload one , you can have a trickle down effect on ones close by- mdma and its dopamine release dependent on high levels of serotonin release, which you can quickly become tolerant to hence loosing the magic.

for some reason even with ethcathinone/buphedrone once you have taken large repeated doses there is a mellow loved up edge, same with amphetamines

anyone able to explain/critique this subjective experience?

 

[pofacedhoe]

Can I relate an anecdote that isn't completely off-topic, perhaps one of you fine minds in here can tell me what this means.

I went pretty hard with ecstasy for some years, usually with very good quality/strong pills, but after a few years of fairly regular (weekly) use, I started developing severe nausea after taking them. Usually nausea would be brought on by a cigarette, but would continue after smoking finished... it tends to persist for up to two days after taking ecstasy (and after having slept) and at times was so bad I pretty much stopped taking pills because of it.

The timing of the onset of this nausea leads me to believe it could be related to a period when I started taking 5-HTP regularly as a pre and post-load. If I take 5-HTP now after taking MDMA, the nausea is so unbearable I cannot leave the house. I can take 5-HTP at other times when I haven't taken MDMA and don't feel sick, if anything I feel quite happy the following day.

The thing is, post-methylone, I also notice this nausea-effect but nowhere near as bad as compared to post-MDMA.

Post-mephedrone, this nausea isn't there at all, nor after taking meth or LSD.

After trying methylone, I assumed that the nausea was related to serotonin release. If that's the case, then it's also my assumption that mephedrone is significantly less serotonergic than MDMA or methylone.

PS. I would like to state in advance, to spare the embarrassment of the ADD mods that my level of technical understanding of drugs is not representative of this forum or it's staff.

well methylone and mdma are both serotonin releasers- i always found that mephedrone felt like an ssri and a decent stimulant like cocaine mixed together. i also get nausea from mixing 5htp with mdma or tramadol (serotonin releaser) yet not from mixing 5htp with mephedrone (bear in mind i never get nausea from tramadol without the 5htp). the "loved upness" from meph is barely there at all and is more of a mellow edge mixed with a dirty rush. methylone is far more love feelings

 

[rnd.id.]

Once again, a prime example of the ever-elusive power to "feel" certain neurotransmitters that some people seem to possess but which I never quite understood.

It is amazing how far the bullshit that big-pharma feeds you can go, ie DA = stim, 5-HT=Love...etc.

Wait, I think it's a strawman that people claim to do it via the indirection of observing "stim" and "love". We take drugs with known molecular actions, and train some sort of "direct sensors" in our minds -- similarly to how we learn to recognize our emotions in the first place; we learn to link a class of subjective states to a word.

Granted, one complication is that there aren't any common selective DRIs or dopamine releasing agents (AFAIK). Though I guess you can infer a bit about dopamine by comparing NDRIs to selective NRIs (reboxetine, atomoxetine).

 

[Jamshyd]

^ While there is an indisputable correlation between, say, high DA levels and self-confidence, there is also a correlation between high levels of DA and vomiting. That does not mean that a dopaminergic will cause both, or either, of these effects.

The mantra that drug-users seem to keep forgetting is that correlation does not imply causation.

It just blows my mind when I hear how casually a LOT of people say "I felt the dopamine when I took so and so"... actually, you didn't. You felt the sum total of the effects of, say, Cocaine, of which only a part comprises a rise in DA levels for a certain amount of time in certain places in the nervous system. Strictly speaking, you cannot really "feel" the effects of individual neurotransmitters, because you are not a radiolabeled ligand, you are a total organism.

 

[swilow]

^All I know is that when I take an opiate such as codeine or oxycodone, I feel the same drive to do things- make music, write, draw, create- that I do with 'nomal' stimulant such as methamphetamine. I link it to dopamine, except that with opiates I actually get things done, whereas with stims, I get lots of little things half done

 

[pofacedhoe]

^All I know is that when I take an opiate such as codeine or oxycodone, I feel the same drive to do things- make music, write, draw, create- that I do with 'nomal' stimulant such as methamphetamine. I link it to dopamine, except that with opiates I actually get things done, whereas with stims, I get lots of little things half done

funny that because, you have a point! if the only neuro transmitter in common between an opiate like oxycodone and amphetamine is dopamine then if you note a similar overlap of feeling to what are for the most part clearly very different experiences then maybe that overlap is the one brain chemical they both overlap in their effect.

we all know that morphine, amphetamine, cocaine, methylphenidate, ketamine, nicotine, cathinone, alcohol, phenibut, THC, MDMA, LSD etc. affect dopamine within the brain. nearly every abuseable drug has some effect on dopamine neurotransmission in the nucleus accumbens. or else we wouldn't have such an urge to repeat these moreish experiences.

in fact if you want a strong feeling of dopamine in the reward centre of the brain how about have an orgasm or eat delcicious food after a prolonged period of starvation.

interesting and also it makes sense

on the point of self confidence that i agree is too subjective and just bollocks but i have done enough drugs now to notice that little moreish rush, same with opium as with crack and just after it levels out they couldn't become more different in effect and mind state.

we are programmed to feel reward (from rewarding stimulus) or at the very least like it but not know why and go back for more-hence it is called reward