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Mephedrone - What do we know?

vortex30

vortex30

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Joined
May 25, 2008
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Toronto, Ontario
I've been doing a little experimenting with 4-methyl methcathinone over the past few weeks, probably gone through about 2.2g to myself, the most I did in a session was 1050mg over a good 5-6 hours. I find an effective oral dose for me to be between 200-250mg.

This little gem has been available for 1.5 years, if not longer, but so far VERY little, if any actual research has been done on it. Everything I have read has been anecdotal reports. Hell, people don't even know if it works on dopamine, serotonin, or both.

Does anyone in the Bluelight community know of any on going or completed research into this chemical? On this one UK forum I visit regularly there are some people doing far too much of this quite unknown substance. Say, 6 days in a row, 600mg+ each day/night. Some report amphetamine like psychosis effects, and for a few it is persistent-ish, all they need is a small dose of Mephedrone and it will come back full force.

200mg is not supposed to be a very high dose, though for my friend the other night, it blew him away, he said it was the strongest drug experience he's ever had. I didn't start him on a 200mg bomb, of course. He had a small line, then ~100-120mg bomb about 6 hours earlier, and that bomb hit him quite well, so that should have hinted to me that maybe 200mg is too much for him...But, alas, he survived, wasn't OVERLY fucked (like seizures, or a freak-out, or something a kin to that where an ambulance may have been needed), just not prepared for whatever effects he was getting exactly (and he's done cocaine, MDMA, 2c-i, mushrooms, probably more, so its not like he is totally inexperienced with stimulants, with additional features/trippyness).

Can we related this to 4-methyl (meth)amphetamine and its 5HT-2B action, which means that these people on this forum are setting themselves up for some serious cardiotoxicity? Or would the beta-ketone group possibly detract from this? Because it seems cathinone and methcathinone, being the beta ketones of amphetamine and methamphetamine, are similar in effects to their counter parts, with a lower duration, but besides that, just basic stimulants.

So, any ideas out there? Any theories in ADD on metabolism, neurotoxicity, cardiotoxicity? The effects of Mephedrone seem to be just 1-2 hours of really great euphoria and intense buzzing and MDMA like, but then it dies down into a really long simple stimulation, that can last quite some time (The night I did 1050mg, I took 2.25mg Clonazepam 3 hours after my last dose, and didn't sleep for another 3-4 hours, so, even with a good dose of benzodiazepine, the remaining stimulation was over powering it). I'm not the ADD type, so this theory of mine may be completely stupid, but I think that the 4-methyl group gets simply 'knocked off' or whatever quite quickly, and it is (obviously) accountable for Mephedrone's more interesting effects, and then you are just left with methcathinone to metabolize, which is obviously less interesting and just simple stimulation.

I'm somewhat worried to keep indulging. There's only been a few reported deaths, and I see people abusing the shit out of this stuff...So it seems relatively safe in the short term...But I really want to see SOMETHING scientific about this chemical. You guys got anything for me? Also, with some of my mental health issues, stimulants are a really bad idea to be indulging in, so I'm keeping the 2.7g or so I have left, and the 1g of Methylone (which I am less concerned about as it has had more research done on it) to special occasions only.
 
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I'd be more concerned about methylone than this, personally. Methylone is likely to result in a 3,4-hydroxy-methcathinone derivative. Dopamine analogue metabolites aren't good for you at all.

Big bad idea.

Most likely there is some 5HT2b agonism, so I'd stay away from it except for occasional parties.

No, that 4-methyl group will not be "knocked off" at least not very quickly. It's possible that there's a para-hydroxy metabolite like you see with the unsubstituted amps, but it'll be a slower process than with amphetamine.

I doubt it's much of a serotonin releaser, if at all. Cathinones have limited effects on serotonin, MDMA > MDMCAT, etc. MDBD is less potent than the cathinone derivative, but I would imagine that's not because of increased serotonicity, but stronger DA reuptake inhibition.

Until Nichols does a real study though, and I imagine he'll look at these closely eventually, especially with the increased popularity. Then we'll have real data. Until then, I'd play it as safe as possible.
 
There are no 'official' publications about this substance; it doesn't even possess a CAS-number.

The metabolism involves most probably reduction of the keto-function into a hydroxy-group, as well as N-dealkylation/deamination. Possible, but less probable would be hydroxylation of the methyl-substituent on the phenyl-ring. These are all speculations, because (as said before), there are no publications on this substance.

In general I would not recommend any binge-like behaviour with stimulants. You said that on "one UK forum" people report about 6 days in a row on this substance, which is obviously extremely stupid behaviour.

Peace! Murphy
 
I'm much more concerned about the retardedly named "methedrone" aka 4-methoxy-MCAT. How stupid, seriously?

First, it's two letters from methadone, and phonetically, really just an r.

MAOI + DARI combinations are dangerous enough, but in one chem it's just stupid.
 
Hammilton said:
I'm much more concerned about the retardedly named "methedrone" aka 4-methoxy-MCAT. How stupid, seriously?

First, it's two letters from methadone, and phonetically, really just an r.

MAOI + DARI combinations are dangerous enough, but in one chem it's just stupid.
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thats a marketing ploy to grab mephedrone users who are thinking it will be similar, stupid name8)

but on the subject of mephedrone i would hazzard a guess based upon how the high feels that serotonin is the strongest component but this bit takes a while to build so the first line can be rushy like coke and all edgy then out of knowhere the anxiety goes and it becomes mellow and mongy and i dont want to move or do anything but watch tv or just mong. if this drug is primarily a NE/DA high then why does it cause such a drop in motivated behaviour. it makes me feel like a non emotional mdma. no anxiety all relaxed cant be arsed.

i have never known a drug that is primarily NE/DA that does not make you move fast talk fast and do lots of stuff.

mephedrone is not like speed at all.

so what is it??? (buff and lush-yes)
 
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Very selective DA drugs lack the "move fast talk fast" to a large extent. That's why I'm not fond of dexedrine.

Starting to get out of my area of interest, so I really can't comment though, because i rather doubt it's a super selective DARI aka the SS DARI- The fastest boat in the fleet.

I'd be surprised if a simple methyl group lends SE selectivity as well though.

Since the cathinones are selective RIs to a large extent, I would not be particularly surprised if it were an SSRI to some extent.
 
Hammilton said:
Very selective DA drugs lack the "move fast talk fast" to a large extent. That's why I'm not fond of dexedrine.

Starting to get out of my area of interest, so I really can't comment though, because i rather doubt it's a super selective DARI aka the SS DARI- The fastest boat in the fleet.

I'd be surprised if a simple methyl group lends SE selectivity as well though.

Since the cathinones are selective RIs to a large extent, I would not be particularly surprised if it were an SSRI to some extent.
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that makes sense as the serontonin effect is a slow build up and seems to last for about 24hours long after the high is gone(massive pupils/emotional apathy-good for the comedown)

one certain thing about this drug is that excessive use will leave your imune system run down (to a similar degree to post mdma flu), probably the combination of no sleep and not enough food(although eating on this was not difficult or unpleasant). its just so easy to be up all night on this then go into work and the lack of sustenance is really managable-unlike speed where the emotions start to spiral and run away like a mad horse
 
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Yeah, I find the come down is mainly just a headache, insomnia, and high-blood pressure related things, a little twitchy, but nothing major like Speed or Coke where I NEED a benzo to get through it, I'm quite happy waiting until I'm ready for bed to take my Clonazepam.
 
Hammilton said:
Starting to get out of my area of interest, so I really can't comment though, because i rather doubt it's a super selective DARI aka the SS DARI- The fastest boat in the fleet.
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I'm sorry maybe I am missing something but what is the SS DARI, is this referring to a drug that is both a SSRI and a DARI or are you talking about a specific compound here?
 
No, the Super Selective DARI aka the SS DARI, the fastest boat in the fleet. I don't think it's confusing. Is it?
 
I don't buy it at present; seems unlikely. amfonellic acid was what I was thinking
 
I would wager that MDPV certainly has some seratonergic activity. Especially upon repeated dosing it, I've found it begins to resemble MDMA in terms of entactogenic and empathogenic qualities.

I don't know anything about Mephedrone but expect to shortly.
 
Hammilton said:
No, the Super Selective DARI aka the SS DARI, the fastest boat in the fleet. I don't think it's confusing. Is it?
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Yes it was rather confusing as there are a number of drugs that are very selective DARIs, it would have been much easier to simply say MDPV in that it referenced a specific compound. Also as muphy pointed out there is no real conclusive evidence as to which DARI is most selective as far as I am aware of. But lets not get too off topic.
 
with regards to mdpv i havent had it so know fuck all but i had heard that it was highly selective for dopamine. its all heresay so until someone can prove it with research its up in the air.
 
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