N&PD Moderators: Skorpio | someguyontheinternet
There is now STRONG evidence that most forms are caused by chronic childhood and adolescent stress, along with isolation.. This leads to way to much glutamate being released which does terrible things to the young brain. Besides causing actual "physcail" damage to axons, dendrites, and synapses, ir chagees the way the brain grows. Causing it to be in a permanent anxious/sad/defensive state and the problem is once someone reaches adiulthood it is much harder to reserve said changes.
Why don't they investigate and administer the ketamine metabolites themselves?
mod edit: These posts were split off from this derailed thread: http://www.bluelight.org/vb/threads/820268-Anyone-Miss-the-DV-What-method-of-DXM-do-you-prefer
and revolve around the claim by Big Stroonz that mental illness is mostly a result of drug use, and perhaps also about DXM's potential to be an anti-depressant lik ketamine or whether ketamine is a valid anti-depressant.
Moved here to get a scientific analysis / second opinion, and of course split being off-topic.
Mental Disorders are caused by mainly, the usage of drugs. Pretty simple, we have very much a clue about how they are caused. It is a chemical imbalance. What causes a chemical imbalance, people who use street drugs and self medicate. This brings out dormant mental illnesses. What else causes mental disorders, traumatic events from childhood, that become suppressed.
I know to be somewhat alone with that but my position is that antipsychotics have strong potential to turn transient psychotic episodes into chronical illness. There are publications coming to the conclusion that "schizophrenia" is statistically better off with just temporary medication as required instead of continuous precautionary regimen. Don't have the links at hand unfortunately but it's on PubMed. And I've seen too many cases by myself
However, long-term administration of antipsychotics can upregulate D2 receptors and produce receptor supersensitivity manifested by behavioral supersensitivity to dopamine stimulation in animals, and movement disorders and supersensitivity psychosis (SP) in patients. Antipsychotic-induced SP was first described as the emergence of psychotic symptoms with tardive dyskinesia (TD) and a fall in prolactin levels following drug discontinuation. In the era of first-generation antipsychotics, 4 clinical features characterized drug-induced SP: rapid relapse after drug discontinuation/dose reduction/switch of antipsychotics, tolerance to previously observed therapeutic effects, co-occurring TD, and psychotic exacerbation by life stressors.
I've never fully understood why people make such a distinction between biology and psychology. They are intertwined.
Wow just read your posting, had overseen it when I wrote my previous reply. Do you have any sources for this particular link between early life stress, isolation and glutamatergic over-activity?There is now STRONG evidence that most forms are caused by chronic childhood and adolescent stress, along with isolation.. This leads to way to much glutamate being released which does terrible things to the young brain. Besides causing actual "physcail" damage to axons, dendrites, and synapses, ir chagees the way the brain grows. Causing it to be in a permanent anxious/sad/defensive state and the problem is once someone reaches adiulthood it is much harder to reserve said changes.