insomnia and anxiety from not taking your supplements
gaba is the system responsible for relaxation. benzos like xanax and vallium are gaba receptor agonists (not saying you take them, just for an idea of what gaba does). when your body has less gaba activation than its used to it will be less relaxed. by taking gaba supplements and valerian root, you make your body used to higher than normal gaba activation
melatonin is the hormone responsible for regulating your sleep cycle. when you take it regularly, your body learns to rely on the supplement to fall asleep.
you forgot to mention that you were taking zyprexa. it has quite a long half life, it may still be in your system when you roll, but not in any major amounts that would effect the roll.
if you were taking these supplements for a long enough time that they make you feel normal instead of sleepy, or prevent withdrawal symptoms from the zyprexa, then keep doing it. they might help with any pre-roll anxiety without adversely effecting the roll too much. you could also try taking half doses of the supplements. also, they are all safe to take after the roll when youre ready to fall asleep. mixing mdma with melatonin might give some realllly weird dreams though