Melatonin - does it make benzos or opiates less effective

[THE_REAL_OBLIVION]

I just woke up at 10:20pm because a goddamn F-18 was doing manoeuvres at this hour over my town, fuckin Harper government. Anyway, it ruined the perfect benzo sleep I was having, and not wanting to take more benzos, I had 3mg of melatonin, the best pills in canada, Jamieson brand. Those things used to floor me, while I was shooting up Dilaudid. Right now I woke up 2 hours later and it's pretty much time to take my bupe, will it ruin the bupe's effects? Which aren't much but it still puts me to sleep, better so when I have antihistamines of the Rx kind (diph does nothing for me, and more than 50mg is asking for tachycardia) so i'm scripted hydroxyzine, but I'm out of it for now, refill only next week.

No idea if this should be in OD or here, it's not that simple I imagine. All I know is that I'm pretty itchy after 2 showers today, I'm allergic to birch and its the worst time of the year for me, all the houses in this area have birches in the back along the fences and i can't keep my window open for too long without getting the itchies, and its not pleasant, might cave in and buy some expensive, even if home brand, desloratadine 5mg tomorrow. The melatonin not knocking me out is still confusing to me. I'm taking my bupe right now, you can still tell me what you think meanwhile. Even if I wanted some air, summer really hasn't come over here in my part of the country, it's 7°c outside at night, crazy, usually I can get decent hours even without benzos and just clonidine and 12,5mg seroquel and breathing through my window while laying in bed.

Goodnight BL, hopefully.

 

[CrazyEngineer]

I'd be fairly surprised if melatonin interacted heavily with benzos and opiates. Benzodiazepines work by activating most of your GABA-A receptors, while opiates tend to work on your opioid receptors. Melatonin has its own set of receptors that it activates; it doesn't directly do anything to your GABA or opioid receptors. It is of course possible that there are complex signal transmission chains inside your body that make use of either GABA-A or opioid receptors in conjunction with melatonin receptors, but I don't have anywhere near enough medical knowledge to speak to that concern. For the purpose of taking a couple of 3mg pills to fall back asleep I'm almost entirely certain you can treat it as entirely non-interacting with benzos and opiates.

 

[THE_REAL_OBLIVION]

Well I just woke up, and I forgot and how wonderful melatonin is. I feel...I feel like I used to when I woke up back in my teenage years and most of my 20's, when I wasn't a benzo user (legally) but still. Thankfully you can get some REM sleep if you use Xanax as your 1-2 punch, it doesn't last in your blood long enough, although temazepam would be preferable. I woke up feeling incomplete when I made the previous post, the extra time melatonin gave me didn't solve the itching everywhere part (I'm gonna try and call the pharmacy and tell em I lost my hydroxyzine script....it's not really something one can abuse, but yeah, I get 1 50mg gelball of Atarax, 30 a month, and most often I end up taking 100mg so I can feel something nod-like from my bupe...a bit silly, but it does work, that with a benzo and you're golden. Anyway, the melatonin made it so that the tiredness, even though way more intense when I woke up, dissipated fast and now my brains seem a lot more awakened, like before I used (other than short acting benzos), for the longest time I had a clonazepam script for day and bromazepam script for sleep. Then I tapered those out with valium, but I'm not touching my valium, the most I can anyway, those blues, I'll use most when I taper (got a plan). I use a couple 1mg xanax to knock me out, doctor won't script 2mg bars, he said drug addicts will steal these from me, heh. Told him the drug "addicts" who come to my house only smoke weed but to him that's like being a masochist and not practising mental hygiene. Whatever that means, Mr.Pristiq-Pen-and-pre-signed-pad (I'm not on Pristiq lol). Only other med I get from him is seroquel 25mg and thats only for very bad situations (bad trips, acted stupid and being without xanax for a week or so...etc.) and i usually only use 25mg, but now that I bought this bottle of Melatonin, I think it'll be a while till I touch the seroquel.