Been smoking Jwh-18 several months, this is not a for or against post but I do know a few things for sure about it, some are open to speculation, as it stands of course there still is no clinical human research on it, let alone long term, so we are our own lab rats. It is pretty decent in responsible doses, for me that's a pretty low dose and high doses are a definite bummer. Some blends are better than others not just as far as potency goes ( higher potency may not necessarily be a good thing ) but as far as the anxiogenic effects go, i was using one blend wich was very potent but it was like playing russian roulette and one little hit could make the difference between a good and a very bad high with a panic attack, high heart rate, etc., also I am sure that there is a cumulative effect if you smoke it all day because I have smoked it all day feeling great and taken ONE hit before bed with an interval of about an hour since last smoking it and had a panic attack. I quit smoking that blend cause the chance of panic attacks happened way too often even with a very small hit or two. Switched to a less potent blend but also a blend with a completely different herbal content, containing Damiana and Catnip and two other herbs, have never had a single panic attack from this blend even after smoking enough to get as high on it as I did with the other blend and I think this is probably from the relaxing effects of those herbs counterbalancing the JWH. As far as the panic attacks and physiological side effects go people have the same wether they are smoking blends or pure JWH and it is obviously possible to get these effects from either form as countless posts testify to so those that say that the herbs in the blends are causing the problems and not the JWH are wrong. Also those that say the side effects are purely psychosomatic are wrong, they are real physiological symptoms as any doctor encountering people in the e.r. will tell you and I don't care how good anybody is at " keeping cool " if they consume enough to have a bad overdose their minds are not going to be able to control what is happening with their bodies, it is not purely psychosomatic, of course freaking out mentally will only make it worse but it is not purely a psychological situation. All this is the part I know for fact from experience, and no I am not a lightweight, have been a heavy cannabis user for 32 years, as well as plenty of psychedelics in my time, and not in small doses, I've also done enough meth in the old days intravenously and not unfamiliar with elevated heart rates etc. A JWH overdose is serious business folks, I have never gone through anything like that before and those symptoms are real, it is nothing to be messed with in an irresponsible way, like I said in smaller doses it is pretty good, this is not an anti-JWH post. Nevertheless nobody knows what this chemical is doing to our bodies and this is not synthetic marijuana, it is not a synthetic THC, it is in no way even structurally similar to THC, if it were it would already be illegal long ago via the analog law. It is something entirely to itself, it just affects the cb-1 and cb-2 receptors like mj. And a big difference is it is a FULL receptor agonist, mj is a PARTIAL receptor agonist and also has many chemicals in it wich balance things out. JWH affects GABA neurotransmission and physiological systems differently because it is a full agonist, being a full agonist does not necessarily mean it is " better " than mj.
Now here's the speculation part - personally I think it could definitely kill a person if they overdose enough and there have in fact been cases of death reported, or at least where this cause is suspected, a few, not many but then the medical establishment knows as much as we do about JWH- virtually nothing and there is no organized data base for cases other than reports from poison control centers, wich is simply based on panicked phone calls to the poison control center regarding JWH. If you search enough on the net you will in fact come upon cases reported in individual counties where death from JWH is suspected, this is not necessarily even from hospital reports because these cases were from people found dead at home, no need for a hospital.
I am a truck driver and have to take D.O.T. physicals every two years or every time I change companies as part of the pre-hire protocol, as far as I know the majority of people posting about JWH are not getting physical exams and hence have no idea about their actual physical condition, we all know anybody can feel fine and go to a doctor and find out they have any number of conditions going on so really nobody has any idea about the state of their actual physical health unless they are experiencing tangible symptoms and even many serious conditions don't have many if any experienced symptoms prior to diagnosis. All I know is the last physical I took not long before starting to smoke JWH was completely fine, no problems, and the last one just a week ago and after smoking JWH for months I found out I have high blood pressure and have blood in my urine, I also have been having a lot of heart palpitations, now this could be caused by many many things and I have to have more tests done of course and I can't say this is from JWH use ( daily ) but I can't rule it out either. I can however say be careful with this stuff, even disregarding my physical completely, this is not a good drug to abuse and definitely not one to overdose on because it is not fun, it can feel far worse than an overdose on even heavy drugs. Be careful out there, dose responsibly.