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[MEGA] Synthetic Cannabinoid Discussion - Take 4

Hey toz,

i hope you are not confusing Ab-pinaca with APINACA (also called AKB48 ) which was an analog of JWH-018 that had a greatly reduced affinity for the CB1 receptor.


the names do seem to run together sometimes,......
 
No way dude, AB-PINACA runs 45 minutes at BEST, and tolerance rises so rapidly with that one it's usually closer to 20.

AB-FUBINACA lasts at least an hour, and with much less pronounced tachyphylaxis.

APINACA (AKB48 ) lasts longer than both of the previously mentioned ones, but is a scheduled compound now. We have workarounds for that though ;)

The main metabolite of fluorobenzyl compounds is 4-fluoro-toluene, which shouldn't be toxic at any realistic dose that could be produced as a metabolite of these, even with very heavy use.
 
N0 W4RN1NG said:
No way dude, AB-PINACA runs 45 minutes at BEST,.
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I beleive that is what I said.
N0 W4RN1NG said:
AB-FUBINACA lasts at least an hour, and with much less pronounced tachyphylaxis.
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at what dose? is it comparable to the reports of 2mg dose of PINACA lasting 45min?
N0 W4RN1NG said:
and tolerance rises so rapidly with that one [PINANCA] it's usually closer to 20.
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tolerance generally occurs when receptors are peaked to a level a specific does no longer reaches.

but that means the agonist itself peaked the receptors, which means in practicality it moved them higher than say a noid tolerance did not build up on.

One way I have found to avoid this with these types of noids is to use CBD or some other regulator that prevents sudden peaks and prolongs the break down of anamadine in the brain resulting in a milder but longer lasting high.
the other way with new synths is to keep dosages low as long as one can, obviously not an option for people whom already have high tolerance due to other noids at higher levels.
N0 W4RN1NG said:
APINACA (AKB48 ) lasts longer than both of the previously mentioned ones, but is a scheduled compound now. We have workarounds for that though ;)
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I am all ears :)
N0 W4RN1NG said:
The main metabolite of fluorobenzyl compounds is 4-fluoro-toluene, which shouldn't be toxic at any realistic dose that could be produced as a metabolite of these, even with very heavy use.
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must be why it is being used in so many cancer and aids fighting drugs these days. ;)
 
PS, no warning,

I hope you find a work around for AB-FUBINACA as well as my last link shows it to be on the DEA radar and being prepared for Scheduling....

I'd like to get back to the THJ122 discussion if we could....

adding the 5F certainly sounds like the way to go to make it active.....

take a few puffs and get back to me! %)
 
dopemegently said:
Does anybody know if APINACA is also illegal in the UK?

Edit: sorry to sidetrack btw
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I know there is a thread over at this sight with a bloke that put it together,

{link removed}

just couldn't find the thread this morning
 
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thanx guys,

I wasn't thinking about the sources clause here, but that sight certainly has them (for the UK). :)
 
N0 W4RN1NG said:
.

5F-THJ122 (MAM-2201 2-indazole) is the only THJ worth it's weight for serious researchers. It is quite good.
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how do you think it measures up to 5F-AB-PINACA,

I'm thinking the 5-fluoropentyl chain is really going to boost it's binding potential, in theory....
 
I have tested 5F-THJ122, it is excellent material. I would rate it a fair bit higher than 5F-AB-PINACA - but then again I'm of the opinion that 5F-AB-PINACA is actually not such a great compound. The tert-butyl homologue is much better.

5F-AB-PINACA is certainly stronger by weight than regular AB-PINACA, though, although tolerance rises even quicker with that one than regular AB-PINACA, and it's shorter too.
 
5F-AB-Pinaca is one of the most unimpressive cannabinoids I have ever tried. Tolerance rises extremely rapidly and the high just has nothing going for it. It doesn't have any physical effects at all and has a weird head high that I can't seem to like nor dislike. It just sucks and is the crappiest cannabinoid I have tried to this date (save for CB-13 which was completely inactive).

All THJs I've only read negative reviews about so I am not about to try any of them.
 
all this talk of tolerance,

I used several noids for the last 5 years, generally the same one for a year and then move on never really experienced any tolerance issues on basic trials, (JWH-018, JWH-250, AM1220, 5f-AKB48, AF-PB22), but then again I use CBD exclusively and low doses to make sure receptors are not peaked, takes half of a year sometimes 3/4 to build up any type of higher does needed....and some of that is just because of trying to push it to get longer effects than the lower dose provides....

I can stay at 2-3mg for at least 4-5months with these aforementioned noids, hit it and quit it.

are you guys vaping or something? what are your dosages per hit?

I don't think it is fair to asses one cannabinoid when other cannabinoids are also being used, the ones you might favor could be the ones peaking your receptors, thus causing the other ones to have less effect.

A fair trial to me would be take a month off of my normal mainstay, then begin critiquing a new one starting a really low doses with a clean slate and receptors reset to baseline.
 
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jeremysdemo said:
all this talk of tolerance, are you guys vaping or something? what are your dosages per hit?
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Yea, usually something between 1-15mg each hit depending on tolerance and which cannabinoid.

jeremysdemo said:
I don't think it is fair to asses one cannabinoid when other cannabinoids are also being used, the ones you might favor could be the ones peaking your receptors, thus causing the other ones to have less effect

A fair trial to me would be take a month off of my normal mainstay, then begin critiquing a new one starting a really low doses with a clean slate and receptors reset to baseline.
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True, though 5f-ab-pinaca remained unimpressive after a months break too due to extreme tolerance build up. I could only get high a couple of times before I got almost immune to the effects. This happens with some cannabinoids and it really bothers me when it does.

FDU-PB22 - Anyone tried it? Got some arriving tommorow.
 
^ FDU-PB22 is nice, but Toz if you're the kind of guy that gets 'immune' after a few hits until the next day (Im the EXACT same way, so I know what you mean) you will have to take it easy on FDU. It is less strong than F**-PB22, for instance.
 
^Yea I easily get immune if I smoke too often (and with some 'noids I just get immune almost instantly anyway). I try to wait untill the full duration of the high has finished otherwise tolerance will skyrocket.

Any idea how Pb-22 compares to 5F-PB22? Got a gram of that arriving as well and some BB-22. I have to find some replacement for 5F-AKB48 that used to be my daytime-noid untill it got banned along with 5f-pb22 and some others. Ab-Fubinaca is nice but it's so sedating it's not really something I want to smoke during the days just to keep withdrawal at bay.
 
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i wish there was more information out there as to what the combustion products of these things are

i suppose i can at least take solace in the fact that the doses are so low that any potential health hazards will likely be pretty minimal

knock on wood
 
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