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[MEGA]Synthetic Cannabinoid Discussion- 2nd Toke

Anybody have an experience with URB 754. i know its not better then any of the JWH's or AM's but just wanna know how it compares?
 
No experience to speak of, but it should be significantly different than any of the AM JWH or THC analogs we have experienced so far. URB597 URB602 and URB754 are not directly cannabinoid agonists themselves. They inhibit breakdown enzymes for endogenous cannabinoid agonists anandamide and 2-AG, thereby increasing the concentration of each in the bloodstream.
I'm not sure what activity they would have on a regular cannabinoid user when administered alone, but they could be dangerously potent when combined with any of the more traditional cannabinoid agonists. Stay safe everyone! and do get back with an experience report if you acquire some.
 
am-2201 ruining marijuana

i've been smoking a homemade smoking blend with am-2201 for the past 8 months. every day, all day. i switched to it to pass a ua, and just stuck with it because i was getting it a lot cheaper and safer than i'd been getting herb. well, the other day i tried smoking real (good real, not reg.) and i got nothing but a headache. i didn't get high, i didn't get the munchies, no cotton mouth, nothing. i tried more, and still nothing. my husband who also smokes the am-2201 with me doesn't get high off of real anymore either. has anyone ever experienced or heard of this? what can i do to fix it?
 
Enix150 said:
No experience to speak of, but it should be significantly different than any of the AM JWH or THC analogs we have experienced so far. URB597 URB602 and URB754 are not directly cannabinoid agonists themselves. They inhibit breakdown enzymes for endogenous cannabinoid agonists anandamide and 2-AG, thereby increasing the concentration of each in the bloodstream.
I'm not sure what activity they would have on a regular cannabinoid user when administered alone, but they could be dangerously potent when combined with any of the more traditional cannabinoid agonists. Stay safe everyone! and do get back with an experience report if you acquire some.
Click to expand...

The FAAH inhibitors don't seem to be very recreational, by all reports (except ones that look like vendor shills). Doesn't look worth it for recreation, but might be useful if you'retrying to use them therapeutically.

They will not produce potentiation of other cannabinoid agonists unless those cannabinoid agonists are fatty acid amides. Which none of the synthetic or natural cannabinoid agonists used recreationally are.
 
bonzz said:
i've been smoking a homemade smoking blend with am-2201 for the past 8 months. every day, all day. i switched to it to pass a ua, and just stuck with it because i was getting it a lot cheaper and safer than i'd been getting herb. well, the other day i tried smoking real (good real, not reg.) and i got nothing but a headache. i didn't get high, i didn't get the munchies, no cotton mouth, nothing. i tried more, and still nothing. my husband who also smokes the am-2201 with me doesn't get high off of real anymore either. has anyone ever experienced or heard of this? what can i do to fix it?
Click to expand...

You've worked up a wicked tolerance, I suspect. Synthetics are real good at that - you can get a really high tolerance without really noticing it. You're gonna need to take a break from cannabinoids.
 
Enix150 said:
No experience to speak of, but it should be significantly different than any of the AM JWH or THC analogs we have experienced so far. URB597 URB602 and URB754 are not directly cannabinoid agonists themselves. They inhibit breakdown enzymes for endogenous cannabinoid agonists anandamide and 2-AG, thereby increasing the concentration of each in the bloodstream.
I'm not sure what activity they would have on a regular cannabinoid user when administered alone, but they could be dangerously potent when combined with any of the more traditional cannabinoid agonists. Stay safe everyone! and do get back with an experience report if you acquire some.
Click to expand...
I am getting a small sample soon so i will report back after testing it out.
 
In my youth I always heard to hold it for around 7 seconds, but by now it's become subconscious... probably at least a 7-count though
I have noted a positive difference if held in longer
 
what would you guys say are the less anxeity causing synthetics ?????????


thanks bezel
 
i have many a experience with panic/anxiety and weed. For me it doesnt matter if its 'swaggy' stuff or the best around, it depends on the situation and scenario. like if im with unfamiliar people, people i dont really prefer; if we are just chilling out or if its a scenario where we smoke before going in the mall or something. it was always the same tho' very rapid heart rate, or beating hard and general unease ranging to 'normal nerves' to almost like "am i finally losing it??" kinda feeling, not very nie at all.
 
What's a good long lasting cannabinoid? I like am-2201 but it only lasts 20 minutes then you crash.
 
they all range about 20 min to 45 min. Making a blend like say: 018, 250, 251, and some 073/081 would make it last about double to triple the amount of time. Oral dosages have a long onset and long peak duration.
 
081 has much longer duration than most, (up to a few hours) it mixes well with the others, and acts a bit like tofu in that it expands the effects of coadministered cannabinoids rather than having strong feelings of its own.
210 is QUITE potent, has an incredibly long duration (I usually get 4-6 hours, but with higher doses I have seen up to 10!) and a deceptively slow come-up. (it is an easy mistake to think the 210 isn't working and then to redose, ending in an accidental overdose or seizures)
All my info is from smoking rather than digestion or insufflation.
 
So what're you guys & gals favourites?

After trying something around 20 different synthetic cannabinoids over the period of 3 years, trying each one at least 10 times with the exception of HU-210 (twice) and CP 55,940 (once),I think my favourite is still JWH-073. It's milder than the others (something I quite value, actually), yet qualitatively very pleasant, mellow, and negligibly anxiogenic (unlike its +1C relative, 018!).
After that would come CP 55,940, even though i've only tried it once. Just a notably awesome headspace. Then JWH-122, and JWH-081. (and so on, and so on)
Least favourite would be HU-210, heavily sedating, and really, really long lasting (~48hrs).
 
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