[MEGA]Synthetic Cannabinoid Discussion- 2nd Toke

[Axed]

Since I got caught by my school's public safety, I've been a little more paranoid when I'm smoking in a place that isn't completely secured. But still, I smoke with people that are constantly very paranoid, for no reason other than they're high and doing something illegal. It's a buzzkill sometimes, trying to calm them down.

 

[skillet]

There actually is some science regarding paranoia from cannabis.

http://www.jneurosci.org/content/31/14/5300.abstract?sid=a97631a0-0d1b-4943-9538-ec0d771694bc

Too bad none of that shit is readable to the average guy...Basically, weed kickstarts a part of your brain to start "learning" about fear.

Great find! I think the important part is: "We report that blockade of BLA CB1 receptor transmission prevents the acquisition of associative fear memory, while having no effect on the recall or consolidation of these memories. In contrast, intra-BLA activation of CB1 receptor transmission or blockade of endocannabinoid reuptake strongly potentiated the emotional salience of normally subthreshold fear-conditioning stimuli."

Which I take to mean that blocking CB1 receptor signalling in the amygdala prevents the acquisition of a fear response to certain stimuli, while not affecting general memory of the stimulus. Activation of CB1 signalling caused the acquisition of a conditioned fear response to occur at lower than normal levels of the fear inducing stimulus.

I haven't read the whole article yet or thought much about the implications. It does seem like a conditioned response though, sometimes even a slight buzz can kick off the same anxiety and thought patterns. And I find that it is mostly existing worries and insecurities that are amplified to the point they become debilitating.

So maybe slight worries gradually become associated with a fear response after prolonged use. I guess this should be permanent though, while most people seem to only experience it while stoned. I'd say I have more general anxiety now than I used to, but weather that's due to weed, I don't know.

Also, I have a friend I used to smoke a lot with that says he gets negative thoughts sometimes and you just need to control it. I don't know if he's talking about the same thing, I find it almost impossible to control, but have managed to get out of it a couple of times. Stubbornness, and the conviction that I should be able to get over it kept me smoking for a long time after it started.

 

[GdaddyP]

swim got 1g jwh-210 today in the mail. Priced at $46.65. His mother tried very little sprinkled on top of a bowl of some beasters and freaked the hell out and got all depressed. Everything that was happening to her and everything that she was thinking about was causing her anxiety. She was just freaking out. swim is typing this now(9:34) while he interviews his mother. But swim filled his bowl with his mother earlier and put a nice 2 little shoveled pile of powder (using the tip of a knife) on top of a bowl of bud and finished the bowl. long body buzz. and the heady buzz sticks with you forever(4+ hours). very nice powder from very reliable vender. swim told me that the jwh-210 is great. And a little goes a long way. It made him feel wicked chill and he could keep a buzz for half the day with a tiny pile dumped into the end of a cig. First jwh he was ever ordered and smoked in powder form. Hes a reliable dude and told me to write (this) a reply for his first time. note new to the site, new member

 

[forums1969]

For me I have always had some anxiety and slight depression, but never enough to effect the quality of my life. Three years ago I started exercising intensely and dieting which allowed me to lose 60 lbs plus I got a new job. At this point my anxiety and depression were pretty much gone and I was happy. When I was working I had medical insurance so I did a six month treatment plan with "accutane" and I never got the depression while on it also it worked very well for me. When things at worked slowed down they starting firing people and I was one let go, but it didn't bother me to much because I was confident I was going to find a new job and life would turn around. I was on my last week of accutane and some people I knew were having a party so I decided to drink some alcohol. I had a low tolerance since I hadn't eaten that day or drank in awhile and was making some bad choices. Someone I used to be friends with went outside and I followed to get some air and sit down. He started smoking this stuff that he said he bought at a smoke shop legally. So I took a puff of it and held it in for 12 seconds. The next thing I know my body shut down on me and I had a terrible weed trip. Something I was not expecting to happen or wanted to happen. I later found out the stuff was called "Ultra Cloud Ten" and that it was a fake weed. The whole experience called extreme fear, paranoia, insomnia, anxiety, depression, depersonalization and derealization. Fast forward seven months later and mine big issues are I have this anxiety which is effecting almost everyday of my life which then causes depression and slight depersonalization and derealization. I was reading that the amygdala effects anxiety and that if the mind and body is stressed constantly it sets like a gauge to max which makes you more prone to suffer from it. Sorry about the long post, but my question is who would be the best person to see to get this under control and resolved so I can get on with my life. I went to the hypnosis and they gave me their sell's pitch which I would try, but they want $X [prices~]. If it was guaranteed to work then I would do it.

 

[IamMe90]

drop the SWIM/mother act, we all know it's you taking that jwh-210 and SWIM acronyms aren't allowed on BL anyway Welcome to the site!

Synthetic cannibinoids can be a little rough if you overdo them, but indeed "a little goes a long way"

 

[northstar]

I wanted to post on this forum because this conundrum has always intrigued me.

FYI - I was a very big smoker for a little over 2 years (junior & senior year in highschool), I would say close to every day - smoking with good friends and strangers alike - and I was always able to enjoy myself, I never dealt with consistent paranoia or anxiety. I had even come in very close encounters with police on multiple occassions and that had never had a lasting effect on myself.

I then moved onto my undergraduate studies - where I was introduced to new people and new ideas, all of whom only seemed to enhance the idea that cannabis was good for the mind and for intelligent thought in general. - Which, I to this day, believe to be true.

After my first semester, literally the first night I was home from school, I was 'caught' by my parents (who weren't mad - just disappointed in me & worried because I had left such a potent strand in my pockets for them to discover that they thought it was laced...)

Ever since that experience I have been unable to enjoy my high. Comfortable situation or not, the Netherlands or the US, combined with e/lsd/shrooms or by itself, weed consistently makes whatever situation I'm genuinely horrible.

I'm not posting here to complain about not being able to enjoy my high anymore, or anything along those lines, I'm just trying to find out for myself why this has happened. Why, in what seems, one bad experience can ruin a lifetime of smoking? Is partly due to myself aging? Could it be contributed to the fact that as I have grown older, I have become much more intelligent than my naive self was in highschool? ...as they say ignorance is bliss...

And if so, why does age affect what seems like more than just a few people in them being able to experience an enjoyable high?

 

[chitown rollin]

This is why I hate smoking weed. I feel that casual users of the drug will not really experience this for whatever reason, but heavy users like myself get extreme paranoia. I even saw a psychiatrist and was prescribed benzos (Not knowing it was from the marijuana.) I have now not smokedi n 4 months and have not experienced any anxiety what-so-ever.

 

[regal]

A lot of people want to avoid the illegal drug transaction scene. Chronic pain patients with legitament need for indica have no access in most of the world. I for one fall off into a schizophrepnic freak with smoking commercial weed.

It is a shame that the JWH-200 was outlawed. I experienced real pain relief from JWH-200 without any of the schzo stuff that can come with cannibas.

It also expels from the body quicker which means it doesn't affect your intellect the next day at work. There were also scientific papers proving thearaputic pain reduction with the JWH-200.


It doesn't seem to be addictive, and I just can't understand why the government made it a shedule 1.

I don't know much about the other JWH's, but as far as I can tell nothing is as effective for pain control or even close?

 

[saintmenot]

Hey all! I bang MDPV!!!!! LOVE IT! So here is another PV3 out on the market. Wondering if anyone has tried it and if it is better than MDPV or the same?????

 

[Enix150]

Hey all! I bang MDPV!!!!! LOVE IT! So here is another PV3 out on the market. Wondering if anyone has tried it and if it is better than MDPV or the same?????

PV may be synthetic, but it is most certainly not a cannabinoid! sorry, but this is the wrong place to post that, budday!

A lot of people want to avoid the illegal drug transaction scene. Chronic pain patients with legitament need for indica have no access in most of the world. I for one fall off into a schizophrepnic freak with smoking commercial weed.
It is a shame that the JWH-200 was outlawed. I experienced real pain relief from JWH-200 without any of the schzo stuff that can come with cannibas.
It also expels from the body quicker which means it doesn't affect your intellect the next day at work. There were also scientific papers proving thearaputic pain reduction with the JWH-200.
It doesn't seem to be addictive, and I just can't understand why the government made it a shedule 1.
I don't know much about the other JWH's, but as far as I can tell nothing is as effective for pain control or even close?

I could not agree more! everything you said is spot on with my observations. have you considered trying WIN 48,098 (Pravadoline)? I noted similar analgesia, although the typical CB1 effects were noticeably missing.
EDIT: You should also look into JWH-5C, I believe it to be quite similar to 200.

 

[professor bob]

A lot of people want to avoid the illegal drug transaction scene. Chronic pain patients with legitament need for indica have no access in most of the world. I for one fall off into a schizophrepnic freak with smoking commercial weed.

It is a shame that the JWH-200 was outlawed. I experienced real pain relief from JWH-200 without any of the schzo stuff that can come with cannibas.

It also expels from the body quicker which means it doesn't affect your intellect the next day at work. There were also scientific papers proving thearaputic pain reduction with the JWH-200.


It doesn't seem to be addictive, and I just can't understand why the government made it a shedule 1.

I don't know much about the other JWH's, but as far as I can tell nothing is as effective for pain control or even close?

what schizo stuff??

I was just diagnosed schizo affecteded and go crazy when i smoke weed.

Regardless, the new fake weed makes me go crazyyy.

 

[professor bob]

also, does anyonyone know whats in the new fake pot. After jwh got illegalized, the stores introduced a new fake weed to the shelves.

Ive been wondering whats in it.

 

[spacehead]

The thing with all these synthetic thc blends is that they only say what chemicals aren't in them. Certainly still part of the jwh series, just not the banned ones such as 018, 073, 200 etc.

 

[Enix150]

@bob: use the edit button instead of double posting and by schizo stuff I believe he meant increased anxiety or paranoia, possibly coupled with perception change or hallucinations.. basically the crazy feeling some people get from weed and many seem to get from alot of these synthetics. (I have read that increased levels of CBD in cannabis will decrease many of the unwanted "schizophrenic" side-effects, but these neuromodulatory effects present in cannabis are lacking in many of the herbal blends.)
JWH was not illegalized, friend; JWH 018, 073, and 200 were the only ones to be banned. (excluding CP 47,497 and its homologue) You're also forgetting that JWH is just a naming system devised by John W. Huffman to label many not-necessarily-related cannabinoids. There were other professors that did similar work such as Alexandros Makriyannis, who named the AM cannabinoids or even the HU cannabinoids from the Hebrew University. Just look for these cannabinoids on wiki you'll find some lists I've compiled.
and there's plenty of synthetic cannabinoids that are still legal and likely being sold in these spice blends not only labelled JWH-xxx, but from each of the many categories and, undoubtedly, some that have yet to be identified to the public.

 

[ParalyticSHOCK]

This is why I hate smoking weed. I feel that casual users of the drug will not really experience this for whatever reason, but heavy users like myself get extreme paranoia.

Strangely when I was smoking heavily I experienced no paranoia. It was when I reduced my intake for a period of time then started smoking heavily again that I started experiencing heavy anxiety and paranoia.

All my friends think I'm crazy for it.

The anxiety is so debilitating that I really just can't smoke the green anymore, which makes festivals and parties really painful for me because everyone wants to share. I often feel like I'm being rude when I turn it down.

I often get comments like "Pfft, I ain't scared". or "WHAT? Why can't you smoke?".

Even if I'm on other drugs at the time people seem to assume that I look down on smoking weed for some reason, when I really don't. I encourage my friends to blaze and not worry about me when I'm not smoking.

Anyway sorry for the ramble.

 

[ltr67]

this shit is no joke.. it also feels ridiculously euphoric..couldn't keep me away from the naughty stuff

10mg is plenty to start with if JWH- tolerance exists.. To me it seems 2x more potent than 018.. but its character is more reminiscent of a hybrid with slightly mild tryptamine-like effects

Spot on! Based on compiled data (smoked. 2-4mg), JWH210 definitely mimics a Sativa/Indica hybrid. However, after reviewing various experiments, JWH210 while being a very unique Cannabinoid, is one of the testers least favorite in the JWH series. Certainly not bad by any means, but not as satisfying as some of the other JWH variants.

That being said, JWH210 is excellent when mixed with other Cannabinoids.

 

[whippa craka]

Soon I will be receiving 1 gram of JWH-122. I plan on taking it orally and putting 5-10mg at a time in capsules.

I am trying to find some answers, but can't find any. I know absorption of the chemical is better when taken with fatty foods. I have seen people taking their powder and dissolving it in ethanol or acetone and then they just smoke it or eat it anyway. Whats the reason in doing this? Is the high better?

 

[Vader]

I don't know why you'd swallow acetone. The reason they are doing this, I imagine, is to make dosing easier. Eyeballing a 5mg dose? Good luck. Dissolve a gram in a litre of vodka, though, and suddenly it's very easy.

 

[regal]

what schizo stuff??

I was just diagnosed schizo affecteded and go crazy when i smoke weed.

Regardless, the new fake weed makes me go crazyyy.

Avoid the fake weed (blends) as most still probably have JWH-18 (even when they say they don't) which is probably giving you the issues also 210 and 250 I think you should avoid. Be very careful with dosing! If you had access to good pure heirloom indica that would be OK, but the problem with weed and the schizo mentals like us is that the natural cannabanoids stay in the system too damn long, we basically have a very low tolerance to the psychedelic side-effect of weed. If you aren't a pain patient and are just after a high, the issue is probably best avoiding by staying away from cannabanoids period, also may want to talk to your doc about neurotin. If you have been prescribed zyprexa, get a second opinion, the stuff is not to be taken lightly.

 

[BotanophileXII]

Cannabis Intolerance and Anxiety

I had been smoking Cannabis regularly for perhaps four years (why I do not know exactly how long is probably due to smoking so much lol) and I have always had anxiety, social phobia and Norephedrine issues before. Smoking Cannabis had helped with my symptoms for the time that I'd used it and I'd enjoyed it quite a bit as well as the other substances I had used. Then one day I noticed that after smoking, I was experiencing a tight sensation within my chest after smoking which is a telltale sign of my panic disorder. Sure, I'd smoked quite a bit and that would be typical with oversmoking but I'd never really oversmoked before. Then gradually this seemed to get worse to the point that I'd decided to give up smoking the drug due to nausea (without vomitting), tachycardia, etc. Just a general uncomfortable sensation in the body when high.
Now, I haven't really been 'high' on Cannabis in seven months, even smoking tobacco from a pipe that has Cannabis resins in it seems to make me uncomfortable in the stomach particularly if I get too much in my system.
I, around the time that I quit smoking, had received a prescription for the benzodiazepine Lorazepam (Ativan) because I developed an agoraphobia that hindered my schooling, socialization, etc.
I now am only able to smoke Cannabis when I have a couple of milligrams of anxiolytics in me and even then it's easy to oversmoke.
I was just wondering if someone had some feedback to explain this, my conclusion is that eventually my extreme anxiety and loathing of nausea has caught up with me and I simply worry about how my body is reacting all of the time.
Any feedback would be wonderful and discussion is appreciated. I will also add that I do not mind being clean off of recreational use of drugs, I am just curious as to why this may have happened. Thank you =]