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[MEGA] JWH-018 Thread

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Gaian Planes said:
ime things with long half lives you can detect effects from longer than things with short half lives if you pay close attention.
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NO NO NO NO.

don't make this mistake ( or read up on pharmacology) ,
For example :
the LSD half life is very short , but the effect is long.
the half life of THC is very long but the effect is shorter.

it also depends on :
if it's a silent agonist (or an antagonist)
deregulation of the receptor ,
you can have long term potentiation ,
you can have enhanced secondairy systems ,
and then there are different potentiation of autoreceptors.
and on...and on.. and on.

and then there are substances that have a different halftimes in the brain than wihin the body.

that's it for now.

but......
......as a general rule you might use this.
 
Coolio said:
I haven't read anything bad that didn't involve an overdose...
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Yes, exactly.
Almost invariably they involve people being moronic and careless. (do we notice a similarity to other drugs perhaps here?)
 
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here is one :

friend , age 34 , occasional weed smoker ,
vaporizes 1 mg of jwh-018 (yellow amber) on a labscale.
within 5 minutes this induces a panic attack so severe that a
short hospitalation was required.

he never wants to touch this compound again.

your ex.
 
There's really no such thing as a panic attack so severe hospitalization is required. There's only people who don't know how to help.
 
Hammilton said:
There's really no such thing as a panic attack so severe hospitalization is required. There's only people who don't know how to help.
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not everyone has benzos or similar available, hospitals on the other hand hospitals do.
it is not always possible to talk someone out of a panic attack, and there is a vicious circle of panic then physical symtoms caused by the panic which worsens the panic and with that much panic, the logic and rational is no longer going to work.
 
What is the efficacy of the talk down method? It was my understanding (pretty sure I read this in the Journal of Psychoactive Drugs (formerly JO psychedelic drugs, IIRC) that it was more than 90% and the other 10% required only minimal intervention. I might be mis-remembering things, though, of course.
 
ex-amine said:
NO NO NO NO.

don't make this mistake ( or read up on pharmacology) ,
For example :
the LSD half life is very short , but the effect is long.
the half life of THC is very long but the effect is shorter.
Click to expand...

PING...

While you're right in a general sense, i.e. one can imagine a drug that lasts for a long time with a short half-life, or even more likely, a drug which has a long half-life, but is short acting, you're examples are not correct.
The half-life of LSD is far longer than THC, Aghajanians Naval Study showed it to be 175 min, while Papac's more recent study showed it to be 5 hours, so averaged about 4 hours. Which fits perfectly.

THC has a v. short INITAL PLASMA half-life, esp. after smoking (Indeed, in rats, the plasma half-life of I.V. THC is less than 5 minutes). This is because it is sequestered into tissue very rapidly. The TERMINAL plasma half-life is very long, (up to 57 hours) as the THC is "drip fed" out of the tissue, but this is in levels far below the levels to get you high. i.e. The levels of THC that get you high leave you plasma with a half-life of approx 20 minutes. See review by Grotenhermen.

It is a very fair assumption that a drug with act with a similar time course to its plasma concentration (usually if you plot drug effect vs plasma concentration you get a circle, plasma concentration leads effect on the rising phase, but as the drug wains, the effect outlasts the plasma concentration).




Aghajanian, GK. and Bing, OHL. (1964). Persistence of lysergic acid diethylamide in the plasma of human subjects . Clin. Pharmacol. Ther. 5: 611–4.

Papac DI, Foltz RL (1990). Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. J Anal Toxicol 14 (3): 189–90

Grotenhermen F. (2003) Pharmacokinetics and Pharmacodynamics of Cannabinoids. Clin Pharmacokinet 42 (4): 327-360
 
Is it water or fat soluble?

I want to try oral but need to know this first.

Regards
 
The only time I consumed a spice product was spice diamond at a party, I had about 3-4 hits of it. Would there be any legitimate cause for me to worry here? I'm half tempted to schedule a full body physical and tell the doctor what happened. I'm 20 years old and the thought of smoking something that is thought to be extremely cancerous and have serious long term side effects is very very frighting. Am I over reacting, or is it that serious? I don't really do any drugs, only marijuana, and this is starting to look like it could have been the biggest mistake of my life.
 
Dcud53 said:
The only time I consumed a spice product was spice diamond at a party, I had about 3-4 hits of it. Would there be any legitimate cause for me to worry here? I'm half tempted to schedule a full body physical and tell the doctor what happened. I'm 20 years old and the thought of smoking something that is thought to be extremely cancerous and have serious long term side effects is very very frighting. Am I over reacting, or is it that serious? I don't really do any drugs, only marijuana, and this is starting to look like it could have been the biggest mistake of my life.
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Dude, stop it, you're getting me really worried. :(
 
Dcud53 said:
The only time I consumed a spice product was spice diamond at a party, I had about 3-4 hits of it. Would there be any legitimate cause for me to worry here? I'm half tempted to schedule a full body physical and tell the doctor what happened. I'm 20 years old and the thought of smoking something that is thought to be extremely cancerous and have serious long term side effects is very very frighting. Am I over reacting, or is it that serious? I don't really do any drugs, only marijuana, and this is starting to look like it could have been the biggest mistake of my life.
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skip the physical and save the money for a casket. 3-4 hits is more than enough to produce instant and irreversible cancer in 100% of users, if you had read this thread you would have known that a long time ago.:(
 
^ Yeah, he's totally right. Do you have life insurance? It's probably smart to get it now before you're diagnosed, before the tumors are just impossible to hide.
 
Jesus Christ, if you could read, you'd know what your risk is. With very light use (maybe a few times a year), your risk is minimal- of cancer anyway.

Stomach bleeding or other non-CB1 mediated effects (which no one knows ANYTHING about) are possibilities that haven't been studied at all, but are certainly risks. JWH-018 is quite similar to indomethacin, so it may be an NSAID, even still.
 
Don't you know that if you follow all the rules and are really really good that you will never get cancer and live to be at least 100 years old;).

Chill-out
 
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The actual brand name is 'arctic synergy'

There is another one out now as well, 'tropical synergy' (the same as yucatan fire? never tried that so I don't know)

I am rather sceptical about the claims of it containing HU-210 though, but it would make it tricky to detect without good equipment, due to tiny quantities needed, along with all the other crapola in there of course.

Hammy, I have noticed that spice (diamond, I haven't smoked much of the others apart from genii and smoke) rips my gizzards a new one unless I take it with antacids.

Then again, I am on indomethacin (actually saw its structure then asked my doc to switch me to it from diclofenac, as it set many cogs whirring in the ol' brain department=D)
And it doesn't cause me any awful gutsache, but YMMV.

Does the 5-substitution bind in the same place as the dimethylheptyl sidechain of HU-210/equivalent chain on plant-derived THCs? the structure of indomethacin looks to me like it might even make an active cannabinoid (indomethacin itself is a very weak CB1 agonist IIRC) if one were to tack on a butyl/pentyl/hexyl group at the indolic nitrogen....



Now to deal with the new(ish) two spice products, as luck would have it, something random made me decide to pay a visit to the local head shop and buy some of both the arctic synergy and tropical synergy.

Sooo...lets see what they have to offer, dust the faithful bong out and let her rip :D
 
Oh sweet fuck..... this is some potent shit, a single bong has pretty much incapacitated me, and the tropical synergy one, hits a lot quicker than diamond (is it now conclusively known what is in diamond, or these two? but the fact it hit whilst I was finishing the bong and almost completely destroyed me (no tolerance currently :D) makes me think it isn't JWH-018

If it is indeed found to be HU-210 I am damn well stockpiling it=D
 
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