I donno, i smoke pot so often, i end up mixing it with everything. But thats because i have a crazy tolerance as well, and i find that pot helps me with the side effects of many drugs. Like opiates, and upset tummies that come along with them. Pot and opiates are a great mix.
Recently ive been experimenting with the psychedelic RC 25i, and i smoke some at the beginning, but usually don't really think about it during the peak which is already really euphoric. But when i start to come down, i find that just a few hits of the pipe will bring my visuals back to full force again. But i find that for a trippy drug 25i leaves you fairly clear minded. I enjoy the presence of pot while i trip on this drug. But should you do 25i and dont feel so comfortable with that trip and the amount of visuals it provides then id stear clear of getting high till about 6 hours has passed since dosing.