medication metabolism question

[Deleted member 137730]

Apparently suboxone/buprenorphine is a highly competitive inhibitor of cyp 2d6 and 3a4 i believe. If one were to keep a stead state of suboxone in the blood would it keep these enzymes fully saturated preventing other drugs with lower cyp affinities of the same kind from ever being metabolized ever. I have reason to believe i have had a single medication in my system for 60 days+ (antipsychotic abilify) from a single dose of medication and it seems to be due to something blocking its metabolization. This is so messed up i cant get it out. im thinking of maybe taking carbamazepine because it is a 2d6 inducer but idk. i tried stopping the suboxone but i cant really because i am addicted to it.


thoughts? if someone comes up with something ingenious that leads to me getting it out of my system i will <thank them.>

 

[23536]

carbamazepine 200mg bid has been shown to increase the clearance of aripiprazole

buprenorphine is not metabolized by cyp2d6

regarding cyp3a4, bupe has a Km of 23.4 and a Vmax of 0.59. I forget what those measurements mean but bupe does not seem to be indicated as anything but a minor 3a4 inhibitor.

did you have the aripiprazole depot injection? That one lasts for weeks.

also, since you mentioned curcumin in another post: if you are taking anything with piperine then you are taking a 3a4 inhibitor

 

[Deleted member 170540]

Abilify(aripiprazole) can be slowly excreted unchanged to the urine even if the liver enzymes can't metabolize it. There's no way how the dose could have been in your body for two months. There are some substances like dioxin that have an elimination half-life of several years, but they are not amines like Abilify and can't exist as water-soluble protonated form.

Do you still feel like you're "fucked up" from the dose you took 2 months ago? I have had psychosis myself and I take risperidone everyday to prevent future psychotic episodes, and I certainly don't constantly feel like I'm "on something". Only thing I notice is that it makes me fall asleep easier at bedtime.

 

[nuke]

Competitive inhibitors are not irreversible inhibitors. The aripiprazole, even if it was metabolized by the same pathways, would still eventually be metabolized and excreted, I'm guessing long before 60 days.

Km and Vmax aren't really useful at all without units, and furthermore without something to compare them to. Vmax is the rate of the maximal amount of product formation while Km is the concentration at which the rate of production formation is 1/2 Vmax.

This is not really advanced, I'm moving it to OD.

 

[Cane2theLeft]

As has been demonstrated above, you did NOT have a single dose of a medication "stuck" in your system for 2 months. It doesn't work like that. If anyone has reason to reopen this, PM me.