Mechanism of anxiolytic *bonus* effect from the "2's" (2-FA and 2-FMA)

[yoyoman]

Everyone who takes either one feels it, notices it. Both stims will reduce anxiety quite a bit but i do not think it has anything to do with serotonin release.. because I am taking celexa (for a few weeks now, 20mg/day) and it TOTALLY blocks any SERT release from 4-fa, or mdma or most anything else.

Its such a wonder drug - when i was taking meth at work (its not like i had a choice, you can't buy d-amp on the 'street') i had to need 12mg xanax spread throughout the day just to cancel out the anxiety. Klonopin, forget it, for some reason it would make me real tired on meth (but not dexedrine for some reason).

Now I don't need to take anything but my prescribed 2mg kpin in the morning, and just dose 2-FMA once or twice during the day (like one larger dose in the morning, usually a smaller one later on). I notice as the 2nd dose kicks in, my anxiety levels just DROP....

It is definitely unique to 2-FA and 2-FMA. Never got this effect from any other stimulant, or really anything at all. Its there its definitely real and not just me, or not just a "confidence increase" causing it or else the other stimulants would do it.

I just really really wonder how it works.. doubt anyone knows.. but maybe someone has a clue here? Its such the perfect stim.. great for anxious people.. no crash/comedown (prob cause of the N-methyl, like meth-lite).

3-FA doesn't have it. 4-FA or FMA i dont even think should be grouped together or even compared. Totally different class of drug (its with mdma and other empathogens, not a pure stimulant like the 2's and 3's)

 

[Epsilon Alpha]

Not ADD, and its probably because of increased 5HT release.

 

[yoyoman]

I doubt it....

Like i said, i'm on a SSRI and it 100% blocks ANY serotonin feeling from 4-FA, MDMA, etc. 2-FMA works the same everyday, and feels the same if i'm on an ssri or not. My pipes are plugged basically. Wouldn't I feel something serotonin like by taking 4-FA?

This stimulant is so good its been called a benzo upper. Definitely ADD material if there is anything to go on, any research i'm unaware of.. i would like to speculate about its toxicity, since i take it daily (and i mean EVERY day) my piss should be loaded with metabolites if i can find anyone who is curious to analyze it, just PM me i'll pay cost of shipping several samples.

Damn no wonder f&b went over to the hyperlab. They actually DO stuff there. They are interested in the cutting edge. This board is going more towards the shroomery. After how many years after shulgin, of all people, said he bets if you put 5-meo-dmt in, you'd get 4-ho-5-meo-dmt out. Google it and all you got is a billion pages of speculation. You got a whole forum full of people growing psilocybin mushrooms. It hasn't even been tried yet? I'd do it all myself believe me, if i had the appropriate space/location. But it just makes me look down and shake my head... lots and lots of bullshit talk, but noooo walking. Lol people wonder where f&b went... dont go bother him he's ... doing stuff.. you know, not just sitting on BL sayin nope, its this, bam. I'm less and less here (i have another more known name here but lost the password). Being lazy, counterproductive, doubtful, close-minded pessimists who *do* nothing to advance, anything.

/end rant

I wasn't aiming this at you, more like, this entire subforum or .. generally.. probably most that post a lot here. Lots of posting... fun... the ol' lab's got a layer of dust on it that makes it look like it hasn't been used since 1843. Ok, end rant for real, i'm jumpin' to the hyperlab (thank god for google translate)

 

[Poodles!]

I've not tried 2-FMA yet but I've been thinking about this myslelf. 2-FA has a "warmness" to it that no other stimulant i've tried has. It doesn't feel at all like the warmness of serotonin release that I'm used to.

Dopamine and noradrenaline can be anxiolytic too though. I guess it depends on receptors involved, drug mechanism etc.. but I lack the knowledge to offer any kind of informed hypothesis. I'm sure the ADD crowd could chip in with something useful, although it looked like this was moved.

 

[DexterMeth]

Fucking science.
I love it.

 

[yoyoman]

Oh here's my thread they moved it without leaving a link lol.

Yeah how the fuck does it work, like literally i can pop 2-fma cap when i'm going out it helps my anxiety (yet amps me up hard too) almost stops it or something its really wonderful. Its like having dexedrine+benzo in a capsule without any of the side effects / addiction of benzo's

 

[DexterMeth]

Haha, that's you. Ya, I must get this stuff. I will certainly do extensive research on it.

 

[PepperSocks]

Since getting off the racemic amphetamine and onto 2-FMA my life has gotten a lot nicer. I never took high doses of amp, but I would take it kinda frequently, say ~10mg a day for studying. Even that ended up giving me some nasty anxiety and facial breakouts.

2-FMA is so much nicer for daily use and concentration, and it's a lot less taxing on the mind.. we'll have to see about the body.

I notice it's about 1/4 the potency of racemic amphetamine. I need 30-40mg for a functional dose. It definitely can't be attributed to molar mass difference of hydrogen to fluorine; there's some receptor affinity differences. Possibly it's less selective as a DA agonist but retains 5-HT agonism activity?

I was wondering if anyone else has any info or hints. Other than the anxiolytic not being blocked by celexa (not mediated by the SERT), we don't know much about it.

I'd also like to look into organic-fluouride metabolism. We know 4-FA is not nearly the toxin 4-CA is, but what of the regioisomers?

I wish the Bulby's, Nuke's and Vecktor's of this site would chime in. (if I forgot another genius' name I'm sorry)

 

[JackieChan]

Having recently done some research with 2-fma while on an SSRI, I wanted to chime in on this thread.

I'm currently on 75mg/day of Venlafaxine (Effexor) and while researching online about various RC's similar to Adderall (I'm a n00b to the scene), I had come across this thread and yoyoman's experiences made me decide that it was the RC for me to try, as I love the feeling of amphetamines and anxiety is the reason I am on Effexor in the first place.

I started some 2-fma testing this weekend and can 100% echo the OP's experience; 60mg 2-fma taken orally provided a very pronounced mood boost, produced an extremely clear-headed, gentle energy, and most interestingly completely eliminated my anxiety.
The only time I really experience anxiety is the day or two after a heavy night of drinking, and I typically use my prescribed Xanax to treat it; I had one of those nights on Friday (LOL) and was still feeling sluggish and a bit anxious on Sunday, so I gave the 2-fma a try while at work. Within ~an hour I was energized, focused, clear-headed and anxiety free. Felt to me like a very "clean" Adderall. Not in the least bit jittery or distracting. The only real side-effect I noticed was a bit of increased sweating (wouldn't have been noticeable to anyone but me).
Felt a bit weird/anxious as it began to wear off, but I attribute that to hardly having eaten all day (as we all know amps kill your hunger), and the fact that my body is still recovering from the events of other day (ie. I was just returning to the state I was in before taking the 2-fma).
My only concern as of now is whether or not I'll be able to sleep; took it at ~ 2pm, and though the main effects have long since faded I'm still feeling quite awake and alert at ~1am.

Although the mood boost was quite pronounced and undeniable, I didn't get any euphoria (at least not from 60mg) so it may lack much recreational value, but from my limited experience so far, I'd say that 2-fma is one hell of a functional chem.