MDMA vs MDA Receptor Activity

[Madrus]

Do we have data yet on the full receptor affinity profiles of MDMA and MDA to compare?

 

[FuckWithRaw]

MDA is similar to MDMA, but its an empathogen-entheogen rather than an empathogen-entactogen. It (as opposed to MDMA) does make one stoned, and at higher doses it tends to be hard to remember the first part of the sentence that a person is speaking. Its generally not considered anywhere near as useful for therapy as MDMA, although some researchers have had some success with it.☆ Neurochemically, MDA and MDMA are quite different. Their active isomers are switched, and MDA seems to effect the 5-HT2 receptor where MDMA is inactive. ☆

A nice little bit on the subject I found on erowid ☆'s around the receptor activity.

 

[Seattle_Stranger]

Very interesting. The MDA I've had in the past feels dopamineageric in the first hour or so, like straight speed, then it gets empathetic. I've wondered if this actually was cut with methamphetamine because it was always like a two-pronged high. The very first alerts feel exactly what I'd imagine a solid shot of meth would feel like. Very addictive, very hyper-focusing, that "super-sober" feeling of confident euphoria. Then, it would evolve in a highly-visual, extremely euphoric roller-coaster roll. I miss that stuff...