MDMA used to work, now it does not (12 years between tries)

[EtchaFletch]

This is my first post in a very long time, and I apologize ahead of time if it is in the wrong area, or if the searching I did for this topic was not thorough enough. I just haven't been able to find anything on this particular situation.

Prior to this year, the last time I had ingested MDMA was roughly 12 years ago. I distinctly remember the occasion because it was one of the more magical moments of my young life. It was everything MDMA was reported to be. Extremely euphoric, heavy sense of empathy...ect..ect..

Now I wasn't by any means a regular user of this chemical, as that was the first time I had ever tried it. After that instance I did not try it again until about a month ago. I received some E from a trusted source who's batch had already been verified by many others, and took 160mg. I felt absolutely nothing. Not even a small bit of euphoria. I tried this again 2 weeks ago at 200mg, and had the exact same results.

I have done some research and found out that people on certain antidepressants and psych medications cannot roll due to the medicines cancelling out the MDMA (I am definitely, definitely not science smart, so I won't embarrass myself trying to interpret what I read). During the period between 2000 and now, I was on SSRI's (paxil, low dose) for about 6 years. I was also on Depakote for about 6 months up until May of this year. Currently I take no medications as my life has very much balanced out, but am still frustrated slightly at this situation. It's not the end of the world if it never works again, but I would at least like to understand it more.

I'm sorry for dragging out the post. Thanks ahead of time.

 

[futura2012]

Hello EtchaFletch

I would say due to being on SSRIs for a long while thats the reason for sure.

Picking up on your quote

" It's not the end of the world if it never works again"

If you can live without I would make a very strong recommendation you leave off MDMA for good.

Clearly your serotonin has been off for a while and now your straight dosing up with 160mG and 200mG MDMA hits wont help. Could be very risky indeed.

Please I am not an anti drug campaigner but in this particular case I would stay well clear.

possibley in say 2 or 3 years down the line you could try it again advised lower dose maybe 80mG or so but once again at your own risk.

I hope this info helps out.




Here is a quote below from another member that explains it all.

Heres the thread for your reference

http://www.bluelight.ru/vb/threads/72100-SSRI-s-and-Ecstasy-The-Final-Word-(Hopefully)

I'd like to clarify this whole mess on SSRI's and Ecstasy.
First the mumbo-jumbo. But it's important mumbo-jumbo, so please read it (or at least skim it.)
First of all, both SSRI's (Selective Seratonin Reuptake Inhibitors )(This includes Prozac, Zoloft, Paxil, and the like, and no, there really isn't any difference between them for our purposes here) and Ecstasy both have affinity (Meaning they will interact with and affect) the brain's seratonin reuptake transporters. Seratonin has an extremely important role in brain chemistry, as we all know, and regulates all sorts of things. SSRI's work by stopping the seratonin reuptake in the brain. The idea is for those that are depressed is that by reducing the amount of seratonin reabsorbed back into one's neurochemical system (and thereby increasing the amount of seratonin present), an increased amount of seratonin will help people feel better (With the help of therapy, of course. Very rarely will SSRI's work without the will and help of both the user and his/her doctor.)
Okay, now for the role of Ecstasy. Ecstasy works by flooding the synapse in the brain with seratonin. (again, as we all know.) Because Ecstasy uses the actual reuptake transporter mechanism to cause seratonin release, obviously any sort of chemical (Like an SSRI) blocking that mechanism (Which SSRI's do,) with a higher affinity for it (Like Ecstasy) will severely reduce or completely eliminate the affects of the Ecstasy. Ecstasy (beyond the threshold dose of ~40-60mg) without the presence of SSRI's generally drains a large amount of the brain's seratonin for 12-24 hours, and the brain has generally not reached full seratonin levels for up to a week afterwards.
SSRI's "downregulate" (inhibit the efficiency & the ability) of seratonin reuptake transporters. This means SSRI's affect your brain's seratonin system in a negative way as well as a positive way; the idea is that the positive effects outweigh the negative i.e. higher seratonin levels outweight the fact that your brain isn't using it as efficiently. Basically this means that even for MONTHS after one quits taking an SSRI, the brain is less efficient at using seratonin. Those who go off SSRI's and take E, even MONTHS later, will most likely have a REDUCED roll, regardless of the amount of E you take. Essentially, your brain's maximum of seratonin concentration (what makes rolling feel good) goes DOWN. So taking more only excacerbates the OTHER affects, like the dopaminergic (feeling speedy)and side-effects (like jaw-clenching).
END MUMBO-JUMBO
Okay, if you're still with me, that's the end of the medical crap. Most eveyone knows this, but a zillion people keep asking about trying E on SSRI's or tapering their meds and are missing the main point. So here goes.
Because SSRI's (prescribed for depression, as opposed to premature ejaculation, for example, because, yes, SSRI's almost always reduce ability to reach orgasm) are prescribed to help people assumed to have seratonin imbalances, most people on SSRI's (prescribed for depression) DO HAVE some sort of seratonin imbalance, tapering one's SSRI's (regardless of the time period, from cold turkey to a month or so) to do Ecstasy is A VERY DANGEROUS THING. It will often lead to an incredible low of depression. I'm talking absolute hell. I'm NOT trying to be anti at all, but I am speaking from my experience and the experience of many people I've talked with. It's just so dangerous for those predisposed to clinical depression (I'm not talking about being sad because your dog got hit by a car, I'm talking diagnosed by a doctor), and those predisposed or suffering clinical depression are often on SSRI's.
Please see my posting thread from my E-experience BEFORE you taper off your meds to do a serious and possibly dangerous drug. I'm not saying E will give you brain cancer or drain your spinal fluid or make your brain bleed or any other rumor garbage, I'm saying your emotions/feelings/mental stability has the severe possibility of getting MAJORLY FUCKED for days, or even a week. Trust me, it sucks.
Please see: http://www.bluelight.ru/ubb/Forum15/HTML/000228.html
Sorry for the huge post, but I just wanted to clarify things.
Quick Summary:
1. SSRI's (all of 'em) inhibit or prevent rolling
2. Those taking SSRI's for depression generally have seratonin imbalance issues
3. Taking E really fucks up your seratonin for a while.
4. For many, this isn't a problem
5. BUT, for those on SSRI's, it may very well be a VERY serious problem.
6. Rolling after being on SSRI's for any significant amount of time will most likely be reduced.
7. Think AT LEAST twice about it
Some warning signs you may be more likely to have a problem when you take E after being on SSRI's (collected from experience)
1. After missing doses (1 day-several days-week-whenever) you go through a withdrawal (i.e. nauseau, "brain bounce"->electro-shock sensations in your head when you move suddenly, or vertigo->feeling like you don't have balance or are "falling up" or sideways.
2. You were/are on a relatively high dose of your med
3. You were/are prone to anxiety attacks associated with your depression
This doesn't cover them all, and even if you fit the bill, you may not have a problem taking E.
BOTTOM LINE: Be very very very careful. Knowledge is everything. This post doesn't apply to everyone; some people can stop their meds and roll and be fine. Some can't. That's just the way it is. I'm not telling you not to. Just please be careful. The last thing I want is for the uninformed to go through the hell I and many others have gone through. Have fun, but most of all, be safe.
Peace
-NYTFLY

 

[EtchaFletch]

Thank you for the reply futura. Luckily nothing negative occurred outside of not feeling the MDMA. I will at this point in time shelf the idea for most likely a good while. No need to break something for the sake of a few hours experience.

 

[futura2012]

Your so right there Etcha

Wish I took that line myself as I stands there at a rave wondering should i take this pill I have been given?

Next thing I know I wake up Shivering, Anxiety, Paranoia you name it ive got it.

Been like this since Sept 2011 now.

I just share my story with people and try and be as honest as possible.

I can guarantee you 100% you have made the right choice and hearing your last post then has made me really happy.

GOOD CALL!!

Not wishing to sound like a total "just say No" lunatic you could try weed that might well still work.

You could also consider some of the psychedelics. However, I have no experience of those but many members on here do and they could advise. 2CB 2Ci spring to mind.