mdma & shrooms cross tolerance

[gdf]

Is there a cross tolerance between the two? Say for example would doing shrooms one night at a festival, have negative effects on dropping some mandy the next night?

 

[Keaton]

I don't believe so...But I don't know for sure.

 

[sakura.summers]

Absolutely not. Not that I've ever seen anyways. You're body may not be too happy with you though so you might feel shitty for a while after. If possible I'd wait a day in between taking them just to give your body a rest, but if that's not possible you'll roll just as hard the day after shrooming

Also, if you want one really amazing night you should try hippie flipping, which is taking ecstasy and shrooms together. Absolutely amazing, you won't regret it

 

[Bearlove]

No cross tolerance with the two - there could be a negative effect if you were say tired, worn out after the first night but nothing really to worry about (will not cause a bad trip).

I have found that Shrooms on the comedown from an MDMA experience gives a very nice trip

I hope you enjoy it

 

[benson7]

I've found that there is tolerance.

In the past I've tripped strongly on Cubensis and then the next day taken E and it's barely affected me, whilst others (who didn't trip before) notice much stronger effects.

 

[gdf]

After researching a bit, I've read that 'Once ingested, psilocybin is rapidly metabolized to psilocin, which then acts as a partial agonist at the 5-HT2A and 5-HT1A serotonin receptors in the brain'. Does this mean it would cause a negative effect if you wanted to take mandy, so soon after? The only experience I have to account for isn't really a strong case - dropped one night at bestival, then the day after had some shrooms and they did a good enough job (granted it was only 2g of libs) and then dropped some more mandy at night as well, but the mdma effects were non-existant, which i guess i can only blame on dropping the night before?

Also is there a cross-tolerance with mdma & 2cb at all?