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Mdma & mxe
- Thread starter DatNiggaJ
- Start date
Best having a look in here buddy
http://www.bluelight.org/vb/threads/641005-Methoxetamine-Subthread-Combinations-2nd-experiment
http://www.bluelight.org/vb/threads/641005-Methoxetamine-Subthread-Combinations-2nd-experiment
Danger! : Serotonin Syndrome!
"Methoxetamine is a dopamine reuptake inhibitor, a nicotinic acetylcholine receptor antagonist, an uncompetitive NMDA channel blocker, a dopamine D2 receptor agonist, and a mu-opioid agonist, according to the current SAR as well as subjective reports consistent with this effect profile.
Methoxetamine has in the past demonstrated the ability to cause serious problems in conjunction with serotonin releasers; the combination of methoxetamine and MDAI (which is a serotonin releaser with no other effects to speak of) lead to the death of one unfortunate Swede who had taken only a moderate dose of both compounds. Simply put: the combination of methoxetamine and a serotonin releaser appears to be extremely dangerous!
It is therefore highly inadvisable to combine methoxetamine with any serotonin releaser or suspected serotonin releaser, or with DXM (a very potent serotonin reuptake inhibitor, though not a releaser) -- this includes MDMA, 6-APB, AMT, MDAI to name a few.
The increasing number of these reports suggest that this interaction is indeed quite real; it is possible however unlikely that methoxetamine acts in some way to inhibit the breakdown of serotonin, via monoamine oxidase inhibition or otherwise. Methoxetamine and the other methoxylated arylcyclohexylamines (4-MeO-PCP, 3-MeO-PCP, 3-MeO-PCE) bear some structural similarity to the infamous PMA and the less-well-known MAOI para-methoxy-phenethylamine (PMPEA). The appearance of unexpected effects is always a possibility when testing a new compound especially testing in vivo with no pre-existing in vitro binding data. To combine these with other compound increases the risk of ingestion substantially."
Probably more an MNS though...
"Methoxetamine is a dopamine reuptake inhibitor, a nicotinic acetylcholine receptor antagonist, an uncompetitive NMDA channel blocker, a dopamine D2 receptor agonist, and a mu-opioid agonist, according to the current SAR as well as subjective reports consistent with this effect profile.
Methoxetamine has in the past demonstrated the ability to cause serious problems in conjunction with serotonin releasers; the combination of methoxetamine and MDAI (which is a serotonin releaser with no other effects to speak of) lead to the death of one unfortunate Swede who had taken only a moderate dose of both compounds. Simply put: the combination of methoxetamine and a serotonin releaser appears to be extremely dangerous!
It is therefore highly inadvisable to combine methoxetamine with any serotonin releaser or suspected serotonin releaser, or with DXM (a very potent serotonin reuptake inhibitor, though not a releaser) -- this includes MDMA, 6-APB, AMT, MDAI to name a few.
The increasing number of these reports suggest that this interaction is indeed quite real; it is possible however unlikely that methoxetamine acts in some way to inhibit the breakdown of serotonin, via monoamine oxidase inhibition or otherwise. Methoxetamine and the other methoxylated arylcyclohexylamines (4-MeO-PCP, 3-MeO-PCP, 3-MeO-PCE) bear some structural similarity to the infamous PMA and the less-well-known MAOI para-methoxy-phenethylamine (PMPEA). The appearance of unexpected effects is always a possibility when testing a new compound especially testing in vivo with no pre-existing in vitro binding data. To combine these with other compound increases the risk of ingestion substantially."
Probably more an MNS though...
Deleted member 290563
Greenlighter
its the best fucking combo ever. don't do the drugs at the same time. do mxe first. and after you peak and start coming down then take your mdma.....ive tried it many different ways, and doing it this way give a synergy and a roll that is just the pinnacle of euphoria and rolling.
As stated above, there is a possibility for negative reactions, but IMO that would require large OD sized dosages of each.
I've also done MXE+MDMA and concur that it is one of the best combos I've ever done, if not the best. MXE first, no more than 30mg, then MDMA, no more than 125mg, and that is pushing it. The MXE potentiates it a lottt. 100mg MDMA with the MXE will most likely have you off your tits. I did 60mg with MXE and had a satisfying roll, no disappointment in lack of effects at all.
I've also done MXE+MDMA and concur that it is one of the best combos I've ever done, if not the best. MXE first, no more than 30mg, then MDMA, no more than 125mg, and that is pushing it. The MXE potentiates it a lottt. 100mg MDMA with the MXE will most likely have you off your tits. I did 60mg with MXE and had a satisfying roll, no disappointment in lack of effects at all.
Deleted member 290563
Greenlighter
exactly, the mxe high/confusion/weirdness hitting at the same time as the roll would just ruin and confuse the comfortable peaceful euphoria that is what rolling is al about.
My best result has been waiting till i'm in the after glow of mxe, then eating 70 mg, letting the roll start to hit...then an hour later eating another 50 mg or so of mdma. Less is more with this high with both of the drugs, too much of either just soils the amazing experience.
My best result has been waiting till i'm in the after glow of mxe, then eating 70 mg, letting the roll start to hit...then an hour later eating another 50 mg or so of mdma. Less is more with this high with both of the drugs, too much of either just soils the amazing experience.
One night i did 30 mg MXE on 300 mg 5-MAPB comedown. It was very scary and dissociating experience. I was sitting on coach and couldn't move. I felt I was dying physically, but mentally and visually it was so intense, that 130 mg MXE alone can't beat it. I thought my whole life was simulation, all people exist only in virtual life in facebook profiles and mobile phones are drugs connected to your brain through headphones. My real life was not real, only virtuality is real. I had thoughts like I finally killed myself abusing drugs and typing every minute to my friend that I'm dying. In one hour or so I was ok with strange thoughts and vision. Also it was my first experience with MXE.