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MDMA mixed with viagra

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Sympho

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Joined
Sep 1, 2012
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Hello, this is my first post on Blue Light! I really appreciate this forum, here I've always found all the infos that i was looking for.
But i won't make you lose time anymore, so i'll just ask my question: sometime ago i read on this forum about mixing MDMA with viagra and i thought that I could try it with my gf. She agreed (guess why... ahaha), and i kept looking about side effects and stuff like that. I'd like to know... is it safe for me to mix them? I'm not worried about my heart that beats faster, because i'm really used to that (I do exercise 3-4 times a week), but I'm scared about the premature ejaculation, I read that it could occurr as a permanent effect!

Thanks for your help, and sorry if my grammar is not perfect, I am italian!
 
AFAIK there is no dangerous interaction. Permanent sexual side effects from ecstasy are mostly myths. I have read some media reports that in theory it might be harder on the liver(MDMA can very rarely cause liver problems) or slow down the breakdown of MDMA(make it stronger and longer-acting), but no case reports. It's probably safe. In fact, it may be good for you, http://www.ncbi.nlm.nih.gov/pubmed/21948520 . Well, at least those doses protected rats, not sure if that crosses over to humans.
 
Hello Sympho

interesting question

Both MDMA and Viagra are Enzyme inhibitors

MDMA affecting substantially the P450 enzymes, Viagra affecting the cGMP-specific phosphodiesterase type 5 enzyme (wow thats a mouthful!)

http://en.wikipedia.org/wiki/Enzyme_inhibitor
http://en.wikipedia.org/wiki/Sildenafil
http://en.wikipedia.org/wiki/MDMA
http://en.wikipedia.org/wiki/CGMP-specific_phosphodiesterase_type_5
http://en.wikipedia.org/wiki/Cytochrome_P450

Many drugs inhibit enzymes.

Drug>drug synergy is a very complex topic. These synergies are often caused my enzyme inhibition. There are many factors to consider including genetic factors.

To know the true answer without a reference source such as previous experiments on multiple people this always requires an element of dice rolling (risk)

If you choose to take this risk you have to approach things with care and caution. Dose being a large factor.


In my process to answer your question with some correct facts I referred to this paper:

Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil

MDMA Viagra Folder

http://www.4shared.com/folder/a2HMwqV_/Drug_Research.html

This paper provides evidence for CYP2C9- and CYP3A4-mediated metabolism of sildenal. Inhibitors of CYP enzymes, specically the CYP3A4 inhibitor erythromycin, are known to produce signicant increases in sildenal Cmax and AUC. Clinicians should therefore be aware of the possibility of drug±drug interactions when prescribing sildenal concomitantly with known inhibitors of CYP3A4. Marked inhibition of the metabolism
of CYP3A4 substrates, CYP2C9 substrates, or substrates for any other CYP enzymes, would not be predicted, as the clinical dose of sildenal produces peak plasma concentrations of only 200 ng mlx1.
Click to expand...

I did a bit of digging around for CYP3A4 and MDMA it would appear that MDMA does inhibit this enzyme in some way. As a result this would cause some type of interaction with viagra. This could produce a variety of symptoms from it being less effective to over enpowering to having no effect at all.

Research determined that MDMA is a CYP3A4 inhibitor and thus raises the concentration of sildenafil in the bloodstream by itself. Sources stated that cutting the dose of Viagra in half would be safe. I took 25mg 1 hour before the peak of 125mg of pure powder Ecstasy and 26mg of 2C-B (4-bromo-2,5-dimethoxyphenethylamine). I am sad to report this was not enough Viagra. In a fit of desperation I snorted the remaining 25mg of Viagra. My effort to achieve erection did not work. Though I had fun anyway, my suggestion to future abusers of this combination would be to simply take 50mg of Viagra initially.
Click to expand...

This is the user report its quite amusing :)

http://everything2.com/title/MDMA%2FViagra+cocktails


If I were faced with your dilemma I would take the option to leave it. Mixing other drugs with a P450 enzyme inhibitors such as MDMA has many risks.

Primarily because theses P450 enzymes are usually the ones that break down (metabolize) other drugs.

This is why it is advised you take MDMA straight not mixed with other drugs. If you mix MDMA with another P450 inhibitor such as a piperazine things get very nasty.

Mixing Viagra and MDMA is a bit of an experiment.

A good place to further research would be to find people who have tried it.

Unfortunately I have no personal experience of taking Viagra or this mix.

Hope this info helps.
 
Last edited:
Permanent sexual side effects from ecstasy are mostly myths.
Click to expand...

I have read some media reports that in theory it might be harder on the liver(MDMA can very rarely cause liver problems) or slow down the breakdown of MDMA(make it stronger and longer-acting), but no case reports.
Click to expand...

I dont agree with this.

MDMA can cause appathy / loss of libido on a long term / permanant basis. Frequently reported long term side effect. Erectile dysfunction is also often reported.

MDMA can cause can cause serotonin down regulation on a permanant basis. Lack of serotonin could cause issues with the liver along with many other bodily / hormone related problems.

MDMA is an enzyme inhibitor and also inhibits itself during metabolization. if you take high doses you danger intoxicating yourself. You mix it with another similiar enzyme inhibitor like BZP you take even larger risks.

MDMA taken in moderation is one thing but it is dangerous advice to make these assumptions.
 
I mean like once you fuck on it you won't be able to fuck again(most common), or in the case of the OP, have permanent premature ejaculation. It can definitely cause depression afterwards when abused, which can lower your libido.
 
I have taken viagra and x before,prefer cialis though. I really didn`t like the way viagra felt. Your experience will depend on the quality of your mdma,and dosage as well. I recommend that you take half of your viagra atleast a week before to see what to expect from it. Then you will have a better expectation of what the combo will be like.

Also, get ready, I would fuck like 5 pornstars while on cialis/mdma combos. 6-8 hours of non stop sex,but never ejactulated. This can be very frustrating for most,but not for me. I would just get my girl to get me off the next day.,
 
Same thing, I heard stories about how you can't keep it hard on e, which was bull. I took a viagra with e and was like a piston that could keep going and going and going but never come. Still, I loved it!
 
futura2012 said:
I dont agree with this.

MDMA can cause appathy / loss of libido on a long term / permanant basis. Frequently reported long term side effect. Erectile dysfunction is also often reported.

MDMA can cause can cause serotonin down regulation on a permanant basis. Lack of serotonin could cause issues with the liver along with many other bodily / hormone related problems.

MDMA is an enzyme inhibitor and also inhibits itself during metabolization. if you take high doses you danger intoxicating yourself. You mix it with another similiar enzyme inhibitor like BZP you take even larger risks.

MDMA taken in moderation is one thing but it is dangerous advice to make these assumptions.
Click to expand...

Thanks for you answer, I was looking for something like that! Can this issues occur even if I take MDMA only once in a smaller dose? I was thinking about 50-60MG.
 
I dont agree with this.

MDMA can cause appathy / loss of libido on a long term / permanant basis. Frequently reported long term side effect. Erectile dysfunction is also often reported.

MDMA can cause can cause serotonin down regulation on a permanant basis. Lack of serotonin could cause issues with the liver along with many other bodily / hormone related problems.

MDMA is an enzyme inhibitor and also inhibits itself during metabolization. if you take high doses you danger intoxicating yourself. You mix it with another similiar enzyme inhibitor like BZP you take even larger risks.

MDMA taken in moderation is one thing but it is dangerous advice to make these assumptions.
Click to expand...

Thanks for you answer, I was looking for something like that! Can this issues occur even if I take MDMA only once in a smaller dose? I was thinking about 50-60MG.
Click to expand...

I made the comment above because when people say things like "permanent sexual side effects from exstasy are myths" and "MDMA can very rarely cause liver problems" it has to be counter acted as this is simply false and dangerous advice.

With ecstasy being a psychedelic, potentially neurotoxic and enzyme inhibitor it has to be treated with a lot of respect and caution. in particular when you mix it with other drugs.

Re your question about 50-60mG dose above I assume you mean in the context of with viagra.

To be honest I cannot answer that question.

It would seem from the comments above you can mix viagra and mdma without adverse reaction but then again everyone is different. Clearly low dose is going to be 'safer' than high dose. But as to how safer this might be I honestly dont know.

Personally if it were me I wouldnt do it but only for the reasons stated above.

Re plugging MDMA, or lining, putting in eyes or injecting for that matter. We have a digestive system for a good reason. Tablets containing binding agent, PVAs, fillers, adulterants and dyes I would not advise doing anything else with other than swallowing.

If you take a look at the manufacture process of MDMA sometime. Just to name one Hydrochloric Acid (9/10) is used in the final salt process of MDMA. Nitromethane can be used in the process prior to this along with ammonia, sodium hydroxide, liquid aluminium you get the picture.

The stomach has a very sophisticated digestive system with its own acids, filtering and breakdown processes for good reasons.

MDMA gives an amazing high through the stomach why take the risk and take it any other way?

Briefly reading the post from iluv I can see how plugging might add some kind of sexual benefit but you would have to weigh this up against missing out on the safety net of the digestive system.
 
"Sextasy" is amazing. Being able to fuck for 6-8 hours with no chance of ejaculation kicks ass. My best advice --> get really good silicon-based lubed. :D

Regarding your ED question, I've found that it hits me when I take more than 250-300mg of MDMA (i.e. redosing over the course of the night).

I recommend Cialis over Viagra, as a single pill is good for the weekend (while Viagra is only for 3-4 hours).

I've found that I get nasty heartburn if I take it with the beans. Nothing quite like a little acid reflux when first coming up.

For me personally, I'll take the Cialis with lunch if I'm planning to roll that night.
 
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