Harm Reduction MDMA, Kratom, and Tramadol (interactions)

[ErgicMergic]

I might be rolling for the first time tomorrow (Saturday evening), and was wondering if I can take a low (1-1.5g of premium Kratom) along with MDMA. I am mildly physically dependent on Kratom (3.7g Super or 5-6g premium once daily), and don't want to mildly withdraw while at a rave. I take tramadol once or twice a week, at 100mg, on my Kratom off-days. I have about 2-3 opiate-free days a week.

Now I know never to combine Tramadol with ANY stimulant (Adderall, coke, MDMA, etc.), because of serotonin syndrome/seizure risk. Also, to keep my 5-HT tolerance down, the last time I took tram was about a week ago. Will I still feel the MDMA? The pills might have amphetamine in them, as they will be untested. Will this possible amp/meth cut interact with the low dose of Kratom?

Is Kratom even serotonergenic? Yeah, the Kratom alkaloids (indoles) have the tryptamine skeleton, but everything I've read states that Kratom works on norepinephrine, not serotonin.

 

[sekio]

As far as I know, kraton is not really serotonergic. It does have effects on norepinephrine, but if you take a "maintenance" dose - enough to feel normal - your MDMA should still work.

Tramadol is nowhere near as potent at messing with serotonin as MDMA.

 

[Oxide]

I actually was just coming here to this forum to ask a VERY similar question, as I'm in the sameish boat right this very second. I took MDMA this morning, I suspect it was an amphetamine-bomb because I don't feel 'rolly' although this is could be because I took tramadol all day yesterday.

I'm dependant on opiates, and have recently scored some tramadol and kratom to help kick the poppy seed tea, and have been switching back and forth or combining them. I took a ~3g (1tsp) dose of Kratom an hour ago, I feel fine, much better actually because I'm not sweating and cold.
From what I've dug up on the subject Kratom and MDMA/amph are safe to mix as long as you don't have serious seizure risks and keep the doses low, and I can attest that I am not seizing out at the moment.

I would seriously like to take 50-100 mg of Tramadol right now though.
Does anyone think I can get anyway with taking a low dose (50-100mg) of tramadol 3 hours after taking a 3/4's of a suspected meth-bomb? I've doses Tramadol in the same day as an "x" (probably amph bomb) pill once before, but there was many hours in between the two as I was wary of a seizure. From what I've found on the tramadol+speed combo, it should potentiate the effects at a low dose, although the seizure threshold will be lowered even more.

I've had a tramadol seizure once from bupropion + tramadol (thanks doc), so I can attest that the seizure risk of tramadol is quite real, not that I've seen anyone say it wasn't.

EDIT: Broke down and took 50mg an hour ago, feel fine.

 

[Bomboclat]

MDMA and tramadol when combined is very likely to cause a seizure

 

[Oxide]

Well the pill wasn't MDMA I don't think, felt like a methbomb to be honest. I spaced out doses of kratom and tramadol throughout the day as needed, no ill effects, but I don't think it was MDMA I was given either.