I don't really think there would be any different..maybe stomach sensitivity if your sensitive already. Someone mentioned eating..i would stay away from heavy, greasy foods and try and have nuts, fruits, cheese, bread, ect around to munch on. I agree that you're might be one hungry person after that experience. About your tolerence you should be totally fine. Rule of thumb when I was tripping all the time was to space it three days apart. Unless you're tripping rather frequently a week should be plenty of time of rest between trips. I love to combine the two substances. I find the empathogenic qualities of mdma (that's what you're talking about by moonrocks, no?) can really help my anxiety with psychedelics. Have fun, stay hydrated and be safe!