Ok, I read a thread a while back where some people were speculating on the effects of diphenhydramine (benadryl, betasleep) when combined with MDMA. There were some folks who seemed to have wandered in from advanced drug discussion but I don't think they ever reached a conclusion. So I decided to try it and see, since recently I've noticed slight MDMA-like effects when taking them for my allergies, such as slight jaw tension and slight mood alteration.
Some things to note:
This is not a labratory grade study. It's just one subject (me) with no real control group. My metabolism is a tad weird so your results may vary. There are no test kits I can find in this country so my analysis of the pills is based on my experience with various kinds. I reccomend testing your pills if you have the means to do so.
Anyway, I managed to get several pills, which turned out to have some MDMA and some meth (bleh) but worked well enough. They seemed about 75-90mg each in weight, I'd estimate their MDMA content around 30-40mg each (assuming a standard pill is 80mg and a fantastic one 150mg), which kinda sucks but it's what I had. At least they all seemed identical this time.
9:00pm: Crushed 2 pills, loaded in gelcap and plugged (standard administration and dosage for me).
9:40pm: Effects start a bit weak, repeat as above with 2 more.
10:10pm: Reasonable come-up starts.
10:45pm: Leveled off. Not a very strong peak but quite reasonable. Take 25mg diphenhydramine pill orally, whole.
11:15pm: No noticeable change. I know from experience a benadryl hits me in about 20 mins standard when I take it for allergies or sleeping. Take a 2nd 25mg pill orally.
12:00am: Slight tingling/buzzing effect. Noticeable but barely. Take 50mg (2 pills) diphenhydramine orally.
12:35am: Intensive tingling/buzzing effect, starts to launch into what seems like a 2nd come up, though it doesn't go very far. Suspect MDMA supply is exhausted. Severe dehydration sets in and I begin consuming lots of water (and peeing it out too). Take another 50mg diphenhydramine orally.
1:00am: MDMA phase obviously done, though not as sharp a dropoff as usual with pills this low quality. Teltale signs of meth bomb sets in. EXTREME dehydration starts, and I have to constantly have water near me. It's less than 5 minutes from a full drink to almost too dry to talk.
2:00am: Meth effects surprisingly mild (usually I react quite badly to it) till this point, then they suddenly intensify a lot. I suspect the diphenhydramine may have been moderating the effect and has now begun excreting. Normally a benadryl works on allergies for 3.5-4 hours for me, so this is a bit soon, but I suspect the amphetamines may have accelerated its consumption. Never had any noticeable effect from last 50mg of diphenhydramine other than more dehydration.
The rest of the night went fairly standard for a "Well I got crappy pills but they weren't a total loss." type night. I didn't take anything more after 1am. I'd like to get some more pure MDMA pills to try and confirm the effects I noticed.
Overall the diphenhydramine was somewhat interesting. I think with a higher MDMA dose it would have been very intense if taken early on so it would be active during the primary come up phase. Crushing the pills may help with a quicker absorption and effect, I'll have to try that next time. However, I do not reccomend more than 100mg or somewhat less depending on body weight (I'm an 85kg/190lb male). You should be prepared for the dehydration effects, if you plan to be very active (such as dancing) I do not reccomend taking diphenhydramine in additon to MDMA at all! Taking more than 100mg is dangerous in my opinion due to the rate at which I consumed water with 150mg. I suspect doses as low as 300mg may be potentially fatal without constant consumption of water, so be very cautious if you try this!
Summary (for the lazy): It does something that would be nice for the come up, but do not take more than ~50mg per 100lb/45kg body weight, and keep extra water around if you do! NOT SAFE FOR EXERTION/DANCING, OVERHEAT/DEHYDRATION RISK!
P.S. Had amazing comedown sex 4-6am. 4 sessions, multiple orgasms on the first 2 (one triple one double), singles on the other 2.
Some things to note:
This is not a labratory grade study. It's just one subject (me) with no real control group. My metabolism is a tad weird so your results may vary. There are no test kits I can find in this country so my analysis of the pills is based on my experience with various kinds. I reccomend testing your pills if you have the means to do so.
Anyway, I managed to get several pills, which turned out to have some MDMA and some meth (bleh) but worked well enough. They seemed about 75-90mg each in weight, I'd estimate their MDMA content around 30-40mg each (assuming a standard pill is 80mg and a fantastic one 150mg), which kinda sucks but it's what I had. At least they all seemed identical this time.
9:00pm: Crushed 2 pills, loaded in gelcap and plugged (standard administration and dosage for me).
9:40pm: Effects start a bit weak, repeat as above with 2 more.
10:10pm: Reasonable come-up starts.
10:45pm: Leveled off. Not a very strong peak but quite reasonable. Take 25mg diphenhydramine pill orally, whole.
11:15pm: No noticeable change. I know from experience a benadryl hits me in about 20 mins standard when I take it for allergies or sleeping. Take a 2nd 25mg pill orally.
12:00am: Slight tingling/buzzing effect. Noticeable but barely. Take 50mg (2 pills) diphenhydramine orally.
12:35am: Intensive tingling/buzzing effect, starts to launch into what seems like a 2nd come up, though it doesn't go very far. Suspect MDMA supply is exhausted. Severe dehydration sets in and I begin consuming lots of water (and peeing it out too). Take another 50mg diphenhydramine orally.
1:00am: MDMA phase obviously done, though not as sharp a dropoff as usual with pills this low quality. Teltale signs of meth bomb sets in. EXTREME dehydration starts, and I have to constantly have water near me. It's less than 5 minutes from a full drink to almost too dry to talk.
2:00am: Meth effects surprisingly mild (usually I react quite badly to it) till this point, then they suddenly intensify a lot. I suspect the diphenhydramine may have been moderating the effect and has now begun excreting. Normally a benadryl works on allergies for 3.5-4 hours for me, so this is a bit soon, but I suspect the amphetamines may have accelerated its consumption. Never had any noticeable effect from last 50mg of diphenhydramine other than more dehydration.
The rest of the night went fairly standard for a "Well I got crappy pills but they weren't a total loss." type night. I didn't take anything more after 1am. I'd like to get some more pure MDMA pills to try and confirm the effects I noticed.
Overall the diphenhydramine was somewhat interesting. I think with a higher MDMA dose it would have been very intense if taken early on so it would be active during the primary come up phase. Crushing the pills may help with a quicker absorption and effect, I'll have to try that next time. However, I do not reccomend more than 100mg or somewhat less depending on body weight (I'm an 85kg/190lb male). You should be prepared for the dehydration effects, if you plan to be very active (such as dancing) I do not reccomend taking diphenhydramine in additon to MDMA at all! Taking more than 100mg is dangerous in my opinion due to the rate at which I consumed water with 150mg. I suspect doses as low as 300mg may be potentially fatal without constant consumption of water, so be very cautious if you try this!
Summary (for the lazy): It does something that would be nice for the come up, but do not take more than ~50mg per 100lb/45kg body weight, and keep extra water around if you do! NOT SAFE FOR EXERTION/DANCING, OVERHEAT/DEHYDRATION RISK!
P.S. Had amazing comedown sex 4-6am. 4 sessions, multiple orgasms on the first 2 (one triple one double), singles on the other 2.
Last edited:
