MDMA crystals and Seroquel ???

[doubleheadedeagle]

I have read many other threads on this topic in many different sites but none of them really applies to me, as for the sake of harm reduction I am asking for help:D

I am a high school senior and as the school is doing a trip to another country, (this is every year) and people do many drugs there but what I am concerned is about MDMA.

I am on 400mg Depakine and 300mg seroquel per day for about 7 months now, 100mg Seroquel in the morning 200mg Seroquel at night.

I know that Seroquel is an antagonist at the 5-HT1a and 5-HT2 binding sites, and those are the receptors that MDMA works on, so seroquel makes it useless? or does it?

I know that the half-life of seroquel is 6 hours and after 24 hours I have read that it will be in your system like 10mg or so I can't really recall what was that.

I have never tried MDMA before and I want to try it in this special occasion to make it even more special.

So my question is after using 300mg seroquel for about 7 months will it really get out of my system for 24 hours, and if not how long should I wait?



as for the use of my therapy, I am prescribed those meds for substance induced psychosis, mainly stimulants did that 8(

 

[Cotcha Yankinov]

Hi there, Seroquel's active metabolite has a half life of around 12 hours in the blood, this could be longer for some people and the effects on the brain don't necessarily have a half life of 12 hours, just the concentration of the drug in the bloodstream. So 12 hours after 300mg you would be at "150mg" and then 12 hours after that you would be at 75mg. So 24 hours after your last dose you might be around 75mg. Its really hard to say how long you should wait because when you stop the Seroquel you will withdraw and I don't know how withdrawals will effect your MDMA experience but it could be very bad.

The Seroquel's effect of antagonizing 5-HT2A is very therapeutic, 5-HT2A activation is excitatory and leads to a more psychosis like state. The thing to understand about Seroquel's antagonist actions at 5-HT2A is that it very likely UPREGULATES the receptors, meaning that when you go to use a drug that is an agonist on 5-HT2A like mdma etc you will get way stronger effects because there are more receptors available for the drug. I could definitely see that leading to psychosis. ESPECIALLY if antagonization of 5-HT2A is whats helped you regain your sanity.

I think if you really want the full MDMA experience you should consider tapering Seroquel down to taking 25mg a night before the trip, and if that is hard on you and psychosis returns then cold turkying and doing MDMA within 24 hours is definitely a bad idea. Seroquel is actually an agonist at 5-HT1A, but a lot of MDMA's magic (and most psychedelics) is through 5-HT2A which is where Seroquel is an antagonist, so yes the 5-HT2A antagonism of Seroquel could null out the effects of MDMA 5-HT2A's agonism.

Agonists at 5-HT2A are known to cause temporary "psychosis" like states. 5-HT2A activates dopamine and excitatory brain cells, which btw dopamine is what Seroquel blocks at the higher doses and why its an anti-psychotic. Seroquel won't have that much direct dopamine action at 25mg though, just decreasing dopamine a bit through decreasing 5-HT2A. Psychosis can be from too much dopamine. What I would be worried about is the combined withdrawal of Seroquel and MDMA use causing psychosis again and insomnia, there is also the matter of damage from MDMA. Expect some fucking withdrawals if you cold turkey 300mg anyways. the main effect will be likely insomnia which MDMA can cause on its own too and that's a road to psychosis So if you really want to use MDMA I would try to do it after tapering your Seroquel dose down to 25mg.

ALSO this is all assuming the substance you ingest is MDMA btw, MDMA itself is methylenedioxyMETHAMPHETAMINE. MDMA is an amphetamine! So even by itself its not the best substance for health, but my worry would be you getting a product that is not clean, something more like bath salts/meth. These can cause horrible psychosis and not sleeping for days. If you feel like Seroquel is helping you don't ruin your momentum and give into peer pressure! Don't fix it if it ain't broke. I personally have to advise against MDMA use in this situation.

 

[doubleheadedeagle]

Thank you very much for this advice I thought doing cold turkey but now you made me reconsider as I need to sleep at least these 2 days. I have already purchased the MDMA (so I can't do anything with it but to use it) and it looks very similar to erowid and other photos of it. Where I live here in southeast Europe we don't have meth, and I really doubt that it can be anything but MDMA or MDE but it is very yellowish so I doubt it has to much MDE.

So I thing what I am going to do is I will reduce my seroquel dose to 200mg for today, 100mg tonight and I have done 100mg in the morning, tomorrow, I won't take the morning dose, and take 100mg at night with some zolpidem both nights, and in the third day only zolpiden, and see what will happen. And in the fourth or fifth day I will do the MDMA.

What lead to my psychosis was mainly very very high doses of caffeine (200 gram coffee per day, and more than 300 grams caffeine from energy drinks) and a cold turkey after doing like 10-25 joints of weed per day, and than followed with fluoxetine(Prozac) and after one month of less than 200 hours of sleep, my psychosis started and it lasted only for like 2 months, I had just one psychotic episode, but my psychiatrist insist to take the seroquel as a "preventive", my psychosis mainly consisted with delusions in the beginning, in the mid stage i had one auditory hallucination and some mild paranoia and in the last week before hospitalization it consisted of extreme paranoia, delusions and one occasion I had some visual and auditory hallucination. After a week of hospitalization I had been calmed, but my delusions were still there. And than after 3-4 weeks I could distinguish reality from illusions, and even now some times I have delusional thoughts but I now that they aren't really true.

I still drink caffeinated beverages, but not that much and do weed just once in a while, and my therapy consists of 300mg seroquel, 400 mg sodium valproate and 10 mg of zolpidem.


I purchased like somthing from 75mg to 200mg of MDMA, and I am thinking of doing it on 9th of november or maybe a day after. I will be smoking weed I don't yet know how much from the 7th to the 11th of this month, and some alcohol. than I will go back to my old routine again
In case I have a bad trip or temporary psychosis, what should I do, should I use the seroquel and how much should I use it?
If after the 11th I continue the seroquel as prescribed, what are the chances of developing psychosis again?

 

[Cotcha Yankinov]

I would consider taking your 300mg dose in the event of a bad trip etc.. This will help block the drug and calm you I believe, as it works fairly opposite to MDMA. Although be careful in the assumption that you have MDxx, there are a lot of designer drugs going around. What would be really nice for you to have on hand is a Benzo or two. I mean zolpidem is alright but a Benzo is a little stronger. Oh and btw I recommend finding some anti-oxidants to preload with for your MDxx, vitamin E can be dosed in the days leading up to it.

 

[dextroisomer]

Thank you very much for this advice I thought doing cold turkey but now you made me reconsider as I need to sleep at least these 2 days. I have already purchased the MDMA (so I can't do anything with it but to use it) and it looks very similar to erowid and other photos of it. Where I live here in southeast Europe we don't have meth, and I really doubt that it can be anything but MDMA or MDE but it is very yellowish so I doubt it has to much MDE.

So I thing what I am going to do is I will reduce my seroquel dose to 200mg for today, 100mg tonight and I have done 100mg in the morning, tomorrow, I won't take the morning dose, and take 100mg at night with some zolpidem both nights, and in the third day only zolpiden, and see what will happen. And in the fourth or fifth day I will do the MDMA.

What lead to my psychosis was mainly very very high doses of caffeine (200 gram coffee per day, and more than 300 grams caffeine from energy drinks) and a cold turkey after doing like 10-25 joints of weed per day, and than followed with fluoxetine(Prozac) and after one month of less than 200 hours of sleep, my psychosis started and it lasted only for like 2 months, I had just one psychotic episode, but my psychiatrist insist to take the seroquel as a "preventive", my psychosis mainly consisted with delusions in the beginning, in the mid stage i had one auditory hallucination and some mild paranoia and in the last week before hospitalization it consisted of extreme paranoia, delusions and one occasion I had some visual and auditory hallucination. After a week of hospitalization I had been calmed, but my delusions were still there. And than after 3-4 weeks I could distinguish reality from illusions, and even now some times I have delusional thoughts but I now that they aren't really true.

I still drink caffeinated beverages, but not that much and do weed just once in a while, and my therapy consists of 300mg seroquel, 400 mg sodium valproate and 10 mg of zolpidem.


I purchased like somthing from 75mg to 200mg of MDMA, and I am thinking of doing it on 9th of november or maybe a day after. I will be smoking weed I don't yet know how much from the 7th to the 11th of this month, and some alcohol. than I will go back to my old routine again
In case I have a bad trip or temporary psychosis, what should I do, should I use the seroquel and how much should I use it?
If after the 11th I continue the seroquel as prescribed, what are the chances of developing psychosis again?

Any update? How did it turn out?