MDMA Chemistry/Pharmacology Thread

[bogman]

Anyone hear anything about Red Pacmans and White casino chips, both pills knocking about Ireland atm but fuck all information on them

 

[BecomingJulie]

Ive worked at Glaxo and AstraZeneca, so over the top. Negative pressure rooms, eye wash stations, emergency room purges, no eating in the lab and they go particularly mental about snickers for some reason about nuts...! Madness

That's not over the top; that's just how careful you have to be, when you're making a product that might be taken by unknown people who might be in delicate states.

You don't want a batch of pills going out that are contaminated with something that people might have a deadly allergic reaction to but isn't mentioned on the label because it shouldn't be there.

As an aside, I wonder how many people have discovered the hard way that they were allergic to something that an underground lab technician inadvertently allowed to enter the product? Prawn curry or Snickers bar still on their breath ..... It could just about happen.

 

[ScotchMist]

I was being sarcastic. Unsuccessfully

 

[Ceres]

yes i want my MDMA labelled 'not produced in a factory that processess nuts, shellfish, gluten or GMO, suitable for vegans and god botherers'

 

[Acid4Blood]

Anyone hear anything about Red Pacmans and White casino chips, both pills knocking about Ireland atm but fuck all information on them

yeah man, i have the white casino chips *SNIP*. Big chunky round old skool lookin pills! Havn't tried yet meself but me girlfriend sez they're very clean. Also have a few purple dominos to try which are also very clean according to my gf.

 

[TheDEA.org]

For what it's worth, my guess is that Marquis reagent works by attacking the methylenedioxy ring to produce that distinctive black color change. Different compounds (such as MDMA, MDA, safrole, etc.) might result in different colors because the different substitutions will draw from or contribute to the charge density of the aromatic ring, and electron distribution around a benzene ring has a big effect on color.

At any rate, chirality of the product (such as S or R MDMA) wouldn't have any effect on these electron shifting effects; I would expect R-MDMA and S-MDMA to produce the exact same color change with Marquis reagent.

If Marquis is producing slightly different results from what has been seen in the past, I would guess that it's due to changes in secondary products/contaminants in the pills.

But it's been a long time since organic. Thoughts?

 

[Limpet_Chicken]

You wouldn't get an amphetamine from nitromethane, you need nitroEthane, the chain length increases by one in a linear relationship with the length of the chain of the nitroalkane used when performing the knoevanagel.

Thus nitromethane gives us a phenethylamine, nitroethane an amphetamine, nitro(iso)propane would give a phenisobutylamine and nitropropane itself would give a phenylbutylamine, nitrobutane might be interesting if trying to synth pyrovalerones perhaps.

And some of the alpha-(n)-propyl compounds are very interesting, in that they foster impulse propagation, increasing the amplitude of an action potential without CAUSING one, when it occurs, it occurs of a larger magnitude but it does not do so more often, this is the hallmark of the actions of such things as BPAP and PPAP (benzofuranylaminopropane and Phenylpropylaminopentane respectively, when action potential is fired naturally it is larger, stronger, but they do not themselves these drugs, directly induce neurotransmitter release or at least w/ PPAP and BPAP they are not releasers or reuptake inhibitors.

 

[Brenner]

For what it's worth, my guess is that Marquis reagent works by attacking the methylenedioxy ring to produce that distinctive black color change. Different compounds (such as MDMA, MDA, safrole, etc.) might result in different colors because the different substitutions will draw from or contribute to the charge density of the aromatic ring, and electron distribution around a benzene ring has a big effect on color.

At any rate, chirality of the product (such as S or R MDMA) wouldn't have any effect on these electron shifting effects; I would expect R-MDMA and S-MDMA to produce the exact same color change with Marquis reagent.

If Marquis is producing slightly different results from what has been seen in the past, I would guess that it's due to changes in secondary products/contaminants in the pills.

But it's been a long time since organic. Thoughts?

Interesting. Maybe you are onto something there. If you check Ecstasydata results, a lot of the pills from the 90's contain MDMA + an unidentified substance. Perhaps this unidentified substance (that may or may not have been added on purpose) changed the way the MDMA interacted with the receptors, hence a different experience, and possibly different marquis result.

 

[Limpet_Chicken]

If it attacks the MDO ring then the intermediate is quinolic or quinonic , both dark chromophores.