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Mdma and wellbutrin?

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scythetggg

Greenlighter
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Mar 19, 2024
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I’m thinking of trying mdma soon and I’m taking a break from ssris for it. Will wellbutrin change the experience at all?
 
Its that the effect's of Bupropion ime were unpleasant. And totally ineffective s ADHD med. So that would for me a negative touch will at least be added.

On paper Bupropion is a SNRI, NorAdrenalin is known to give that uneasy edge especially wit stimulant's, but probably aslo with MDMA. Although it seems as if the flood of Serotonin on its own overides the fight or flight response. But in reality it will probably be more complicated. Check for dangerous interaction's first. Now you also mention being on SSRI's, and taking a break from them. So are you on a SSRI and a SNRI (Bupropion)? SSRI's will totally block any MDMA effect's for quite some time I read.

Maybe someone chimes in with what more info on Bupropion and MDMA. That Bupropion raises the chance for convulsion's allready seems like a red flag.
 
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I cant remember if i was on wellbutrin or not back when i took mdma it was so long ago. It could add a unpleasant stimulant edge to it though so id just skip a dose. Wellbutrin mostly acts on norepinephrine
 
Apparently it increases the length of subjective effects when taken together. Now i don't know about chronic use but acutely taking Wellbutrin and MDMA together:

"Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations."

pubmed.ncbi.nlm.nih.gov

Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects - PubMed

3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
emkee_reinvented said:
Its that the effect's of Bupropion ime were unpleasant. And totally ineffective s ADHD med. So that would for me a negative touch will at least be added.

On paper Bupropion is a SNRI, NorAdrenalin is known to give that uneasy edge especially wit stimulant's, but probably aslo with MDMA. Although it seems as if the flood of Serotonin on its own overides the fight or flight response. But in reality it will probably be more complicated. Check for dangerous interaction's first. Now you also mention being on SSRI's, and taking a break from them. So are you on a SSRI and a SNRI (Bupropion)? SSRI's will totally block any MDMA effect's for quite some time I read.

Maybe someone chimes in with what more info on Bupropion and MDMA. That Bupropion raises the chance for convulsion's allready seems like a red flag.
Click to expand...
I’m getting off of ssris for a while (with the permission of my psychiatrist)! thank you, I may skip a dose or two at least of wellbutrin beforehand
(Also, I’m taking it as an antidepressant instead of an adhd med. I also didn’t notice it helping with concentration, and I even tried out concerta and focalin a while ago while on wellbutrin but stopped them because they didn’t work)
 
scythetggg said:
I’m getting off of ssris for a while (with the permission of my psychiatrist)! thank you, I may skip a dose or two at least of wellbutrin beforehand
(Also, I’m taking it as an antidepressant instead of an adhd med. I also didn’t notice it helping with concentration, and I even tried out concerta and focalin a while ago while on wellbutrin but stopped them because they didn’t work)
Click to expand...
Some SSRI's have long halflives. Fluoxetine 5/ 6 days after chronic use. Some people have normal effects after skipping their SSRI a day, or have to take a little more MDMA then their usual dose.

Fluvoxamine is a one that has the highest chance of inetraction. Due to: "agents metabolised by cytochrome P450 1A2 isoenzyme appear most likely to be involved in drug-drug interactions with fluvoxamine."

https://pubmed.ncbi.nlm.nih.gov/8846620/

P45 1A2 and P450 2D6 also breakdown MDMA.

https://pubmed.ncbi.nlm.nih.gov/18794647/
 
emkee_reinvented said:
Some SSRI's have long halflives. Fluoxetine 5/ 6 days after chronic use. Some people have normal effects after skipping their SSRI a day, or have to take a little more MDMA then their usual dose.

Fluvoxamine is a one that has the highest chance of inetraction. Due to: "agents metabolised by cytochrome P450 1A2 isoenzyme appear most likely to be involved in drug-drug interactions with fluvoxamine."

https://pubmed.ncbi.nlm.nih.gov/8846620/

P45 1A2 and P450 2D6 also breakdown MDMA.

https://pubmed.ncbi.nlm.nih.gov/18794647/
Click to expand...
Thank you! I’ll look up the half life of citalopram just in case☺️
 
My friend takes Wellbutrin. They stop it for 3 days before rolling and then restart 24 hours later. Have enjoyed the roll and had no problems.
 
I did mdma while on 300mg Wellbutrin XR- subjectively it felt like all of my other mdma experiences, but after I left the party I was at I realized my heart was pumping super fast and hard (moreso than when I only take mdma). There wasn't any issue, but if you have a predisposition to heart problems I would keep that in mind. I'm also on Wellbutrin for depression, so I don't feel super stimulated when I'm on just Wellbutrin.
 
i've been on wellbutrin for my depression and anxiety about a year now and have been taking mdma as usual every so often with no adverse effects,,,, that being said,,, everyone's body chemistry is different and my experience is completely anecdotal though, so i'd recommend skipping a dose at first just to be on the safe side. please be careful and do your own research!! best of luck!!
 
I take 300mg of Bupropion HCl daily, and was taking up to 450mg when I began interacting with MDMA and MDA. No adverse effects have been noted, but I also metabolize drugs very slowly relative to my bodyweight (~100kg/16 stone/225 lbs), and later on when I had no bupropion in my system, I found MDXX compounds metabolized quicker, but not other drugs. That's the only difference I've ever noticed.

MDXX compounds' capacity to instill empathy is more useful when on bupropion than not, as bupropion is very hollowing to the soul in my experience. Lowkey why I use it though, it allows me to build empathy via cannabis, psychedelics and empathogens instead of whatever other fucked up endogenous shit normally occurs.
 
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