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Mdma and possible problems/interactions with prescription medication

Modafinil is not a euphoric drug. It basically does what it should without any recreational value (unlike say, adderall, which has euphoriant effects). I've tried it and personally don't like it all that much.
 
Actually modafinil is a Dopamine Reuptake inhibitor so it may actually block some of MDMA's effects

Accordingly, it increases locomotor activity and extracellular dopamine concentrations in a manner similar to the selective dopamine reuptake inhibitor vanoxerine, and also blocks methamphetamine-induced dopamine release.
http://en.wikipedia.org/wiki/Modafinil
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Folley said:
Actually modafinil is a Dopamine Reuptake inhibitor so it may actually block some of MDMA's effects
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It's not a dopamine reuptake inhibitor, it increases extracellular concentrations in a 'manner similar'. They don't really know exactly how it does what it does, but it just does. Speed also increases extracellular dopamine levels, and that certainly doesn't block MDMA. Considering that MDMA has a much smaller action on the actual dopamine site (remember dopamine release can occur via serotonin increase, not direct release), I'd imagine anything that releases dopamine directly would increase the stimulant effects of MDMA, instead of blocking them. This could 'take away' from the MDMA magic, but it's still not blocking the effects, just masking the serotonergic effects.

Even so, modafinil is just a weird drug with no recreational value. I see little point in combining it with MDMA, unless you don't want to sleep for 24 hours. Modafinil has a ridiculous half-life of 15 hours, so when combined with MDMA, you won't be sleeping anytime soon. You should avoid the combo.
 
If it's blocking "methamphetamine-induced dopamine release", I'm sure it would block MDMA-induced dopamine release as well.


Continued on from before.. (should have included the full paragraph anyways.)

Accordingly, it increases locomotor activity and extracellular dopamine concentrations in a manner similar to the selective dopamine reuptake inhibitor vanoxerine, and also blocks methamphetamine-induced dopamine release. As a result, it appears that modafinil exerts its effects by acting as a weak dopamine reuptake inhibitor, though it cannot be ruled out that other mechanisms may also be at play. On account of its action as a dopamine reuptake inhibitor and lack of abuse potential, modafinil was suggested as a treatment for methamphetamine addiction by the authors of the study
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I found this while searching for LSD + Modafinil and figured id give my input

I personally find Modafinil to have a lot of recreational value, especially in combination with alcohol

When I have done Modafinil with MDMA it hasn't blocked anything at all, if anything it potentiated the MDMA and I didn't notice any adverse or uncomfortable effects, no more side effects from either than normal. That was 150mg Modafinil + 300mg (in 2 doses) MDMA
 
Litteraly WHACK...Uppers don't really hit me like they use to when I've taken a benzo 36houra prior to taking the x, doesn't come in as hard but was ok gradually kicked in after 2hours and a blunt with OG and wax drippled all over which was extreamly wonderfull, if I might say ;) it helped my roll kick it and these were clean Pillz no Amphetamine just mdma serotonin was running nice euphoria but barely any jaw clenching, I'm from the Southern California 11miles north of Downtown LA and these were clean. Just wish the benzo hadent slowed down the euphoric roller coaster ride I had been trying to ride lol. Any ways of u do not mess with benzo's on a regular basis than you are good, but if Ya do take take benzo's often than I will guarantee it will cut into your other drug and since x is a upper it will slow the euphoric coaster kicking in:.......haven't had clean x pills like this for a while, felt like I was in heaven after 3 hours of taking it, totally feelin the music and ended up climbing into bed with my gf and rocking her world on these Grey Dolphins. X + Kush = sex + 6mg zans and a solo Og kush blunt = heaven. Remember Be responsible when Fucking around with chemicals and drugs, do the research, remember your not a Ginny-pig or whatever be smart and remember "divide it, don't hide it"

-818vallyzmostbenzod
 
First Bad Comedown - Thank you for your explanation. Most people just give the regular serotonin will be gone and you CANT roll (than I see friends at festies rolling 3-4 days straight and claiming (and I believe them) that they rolled every day (anectodally I did witness the dosages going up and the duration being shorter) I really wanted to roll today but it has only been a week and your explanation really shed alot of light on why that would be a bad idea. (that and 10 mg clonazolam idk if id even feel it) unfortunately im not risking it all I have an ungodly tolerance and that is baseline for me, sounds like it would have a deminished roll, increased negative affects "suicide tuesday", minimized duration and intensity) which I already knew but I figured I'd just double the dosage to compensate. (only rolled like 7 times ever at 27 figured it couldn't hurt that bad doing once) but with the lack of tactile sensation in addition to what you were saying. JUST NOT WORTH IT. save it for the 4th, not have to double down or mess my head up
 
Taking Phenibut before MDMA?

I am going to a festival soon that starts at noon and finishes at midnight. I was thinking of taking Phenibut first thing in the morning and hopefully that will keep me anxiety-free and feel good for the start of the the festival, and maybe 1 or 2 drinks/beers throughout the festival, until about 6ish where I will begin my MDMA roll.

Is this combo a bad idea? Will phenibut/alcohol numb the roll? Should I forget the phenibut, and stick with a few beers/drinks?
 
i always take 2mg of xanax before a roll it helps make a smoother come up without any feelings of anxiety which happens to alot of people.
either way if you have pure mdma you should roll just as hard anyways.
 
Mixing DayQuil and Popping Molly tonight

So I drank DayQuil with 10 mg of DXM at 11 am, and I am planning on rolling tonight around 9 or 10 pm, would I be fine?
 
10 hours later around 20%, a little less, of the DXM will still be in your system. 20% at most that is, but you have to assume you're a slow metaboliser. I wouldn't risk it, there is a risk for interactions, DXM is dangerous to combine with MDMA. It could be that 10 hours is enough to avoid interactions so if anyone else knows more about this please correct me, but I wouldn't risk it

*edit* I think you'd be fine a few hours later though, but I think 10 hours is not enough, try to wait at least 13-14 hours (12pm - 1am) but preferably 16 hours
 
At therapeutic levels of dxm, mixing the 2 is not that dangerous imo. Now if you drank the whole bottle then I would be worried. The danger of dxm and mdma combo is overheating. The both inhibit your bodies ability to regulate heat. Add that to 5 hours of dancing in a hot club and it will send you to a hospital real quick. But in a controlled environment with only therapeutic levels of dxm and I think the risk is minimal...There is still risk mind you and I'm no scientists but I bet you'll be fine under those conditions. Safest route is to avoid it all together though just in case.
 
matt2012 said:
At therapeutic levels of dxm, mixing the 2 is not that dangerous imo. Now if you drank the whole bottle then I would be worried. The danger of dxm and mdma combo is overheating. The both inhibit your bodies ability to regulate heat. Add that to 5 hours of dancing in a hot club and it will send you to a hospital real quick. But in a controlled environment with only therapeutic levels of dxm and I think the risk is minimal...There is still risk mind you and I'm no scientists but I bet you'll be fine under those conditions. Safest route is to avoid it all together though just in case.
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The danger is actually serotonin syndrome, which does result in overheating indeed, but a plethora of other symptoms as well. I too think he would have been fine, more so because I have no idea about DXM dosage, but better to err on the safe side of things when it comes to potentially dangerous combinations. How did it go OP?
 
Selegyline and Ecstasy. How safe is it?

I've been taking 5mg daily of Selegiline for 6 months and want to take ecstasy tomorrow night. Is it safe to do that if I skip tomorrow's dose of Selegiline?
I've been reading about seratonin syndrome and am wondering if it applies at my dosage.
I would really appreciate any help. Thanks in advance.
 
Do NOT dose the MDMA until you've been off selegiline for a good few weeks. I believe it is an MAO-A and MAO-B inhibitor, and any serotonin releaser combined with and MAOI can cause serious harm and even death, by way of serotonin syndrome. I'd ideally be off medication for a good month or two before considering MDMA. Please please do not attempt this combo
 
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Thanks so much for your reply. You probably saved me much trouble. God bless. Have a great 2016.
 
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