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MDMA and Oxycodone

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evo4ever

Bluelighter
Joined
Jun 14, 2016
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1,398
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Hello all.

Just a quick question.. Has anyone mixed MDMA with Oxycodone or any other Opioid? And what does it feel like? Cheers guys.
 
Not quite, but same kind of combo of opioid and serotonin releasing agent.

I would argue they do kinda same things, but by different mechanisms and they push to different directions. So, even if it was curiosity, I don't perceive it important to experience this combo. Maybe go for downer in the comedown.
 
The opioid would likely reduce a lot of the stimulation of the MDMA, and either drown out the MDMA or just leave you feeling like they blunted each other depending on dose. I'd suggest taking it after the peak effects and glide from MDMA euphoria to opioid euphoria.
 
Tramadol and MDMA was decent enough. With a tramadol tolerance and low dose mdma. Caution advised. Was good though.
 
even if molly nullified SNRI action of tramadol, it is still 5ht3-antagonist (and obviosly mu-agonist and decreasing release of GABA indirectly), which then decreases seizure threshold. I don't recall reading much of any reports of this combo but basically it is adviced against.
 
Oh aye, inadvisable. Think I had best part of a gram of pregabalin on board too. At least ten pints. It was very high quality mdma.

I had a ball.
 
cosmosmariner said:
I don’t know if there are safety concerns, but at least with tramadol and MDMA, this gave me pause:

MDMA and tramadol or tapentadol co-administration causes serotonin-independent neurological damage | Scientific Letters

publicacoes.cespu.pt publicacoes.cespu.pt
Click to expand...
For the love of God do not mix tramadol and MDMA. Tramadol is a weird and wicked opioid that is also an snri. You are risking a serious condition called serotonin syndrome/storm. Which is extremely life threatening. Without getting to deep into the weeds here MDMA causes the body to realize a massive flood of serotonin. While tramadol work to slow the reuptake of serotonin. Meaning you have one drug flooding your body with serotonin and another that won't allow your body to eliminate serotonin. Basically it can cause a severe overdose of serotonin that can easily result in death. Not trying to scare anyone those are just facts.
 
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