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Mdma And Anti-depressants - Mega Merged

Well after not having signed on in over a year my curiosity has been aroused in the psychoactive discussion community after seeing "Trainspotting," which was phenominal (certainly no Requiem tho.)

So does all this talk about antidepressants causing you to be permanantly unable to roll have any truth to it? I've always heard that SSRI's interfere with the ol' rolling mechanism in the brain while your on them, but permanantly? Like as in months/years after you've stopped taking the SSRI's?

Got me kinda scared after hearing that information for the first time just now, because I've been on Zoloft for a couple of weeks now. I was also taking it for about 2 months last April and sparatically between then. 50mgs.

Anyways, I'd like to get to the bottom of this, how much truth there is to it and if so how significantly one's "ability to roll" will be affected before continuing on the Zoloft.
 
I've never heard any reports of perminantely, buts weeks yeah.
 
I believe I was on lexapro when I rolled my first time (although I can't quite remember, even if I was, I was only on lexapro for maybe a month or so before I stopped) and the roll was obviously VERY intense since it was my first time, not to mention it was definitly MDMA because I have never felt anything like the way I did ever again. I don't take anti-depressents anymore, I have a prescription to remeron, which I only take on nights I can't get to sleep, but I really don't even bother with it anymore. I just went through a short stage of 'depression' which I think everyone has sometime in their life. So I would say you all should stick with the meds until your doctor or you (are definitly sure) you are well, then maybe, if you feel your body is up to it, go back to rolling. Remember, MDMA may be able to induce depression, anxiety, and fatigue. No one knows for sure yet, but better to be safe then sorry.
 
I'm on 20mg of Citalopram and I'm able to roll on a single pill. I don't do it too often, though. Once every couple of months.
 
Also, long term use of antidepressants decrease the amount of serotonin transporter (SERT) in your brain. The SERT is how MDMA releases serotonin; less SERT, less serotonin will be release.

what does long term mean here? 6 months, a year what? i was on antidepressants for about 6 months and rolling has never been the same since then.. could this be why? i've been trying to figure out what it was
 
It could be why (thought I would be surprised). No ones looked to see how long it lasts for.
 
GrizzleBee's said:
I'm on 20mg of Citalopram and I'm able to roll on a single pill. I don't do it too often, though. Once every couple of months.

Citalopram is Celexa, correct? I just started taking Celexa and ur giving me hopes, I never thought i'd be able to roll. Can u describe what its like compared to rolling w/o the Citalopram? Thanks.
 
hi all, just registered. I am on fluoxetine prozac 20mg. I have rolled twice since starting the medication, and although i wasn't in the same place as i had been during my previous session, it really was very pleasant indeed considering i only had a few pink euros. Also worth noting, is that the previous incident involved pure mdma...so no suprises it didn't match up. I became very freindly, open and honest with my friends, and mangaed to share many of my bottled up problems with them. I felt very active and talkative and it certainly felt like a decent serotonin rush.

I'm probably just one of the lucky people, who take this particular medication and only experience a slight decrease in the effects. Hopefully i can simply take a little more than others to get the same results. Does anyone know of any known side effects to combining these two drugs on a regular basis? Regular being about two-three times a month for an indefinite period...
 
Well the main side effect I can think of would be that it could work against the possible antidepressant - anti-anxiety actions of the medication you're taking. i.e. people who take MDMA weakly often end up with anxiety and depression problems eventually.
 
I am sure that in the fullness of time i will cut the habit back to once a month. Hopefully within the next few months. For the time being i will try to be adament about not rolling more than twice a month. I have only recently come into supplies after a moderate hiatus, so i am riding the wave at the moment. I am a level headed young man, and i will keep this habit under control
 
im new...i dropped 1 "adidas" stamped pil tonight and felt very little. i am currently on welbutrin, and lamictal. i know the welbutrin has no side effects, but i was wondering if the lamictal is preventing me from having an experience....i just bought i test kit because out of the 3 times ive rolled in the past 2 months, only once was the experience worth while. i seriously feel nothing but mildly speedy..:( any thoughts?
 
I doubt it's the lamictal (lamotrigine); it's more likely that it's the wellbutrin or you're just getting bad pills.
 
yeah...they more than likely are bad. ive only tried rolling 2 times prior to this.(over the course of 3 months) i dont think any of my pills were actual mdma, so technically i have never had an actual roll. i dont think its my meds because my friends felt nothing from what i gave them either.(except that we couldnt sleep)

also, my doctor just prescribed a low dose of SEROQUEL (25mg) to help me sleep. what are the conflicts if any?
 
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I've been taking Prozac (Fluexetine) for over a year, and although my depression is now much better, I still get them prescribed because I read that rats given Prozac after loads of E showed greatly reduced damage to their serotonin receptors.

I started taking E (although I think its MDA) every weekend for the last 2 months and have tested how taking different amounts of Prozac at different times of the week have had an effect. I've been orally consuming from the same batch of pills and the same batch of Prozac to keep a level playing field. This is what I found:

If I take even 1 Prozac at the same time as 5 pills, 70% of the roll is lost.
This is exactly what happens if I take Prozac at the same time as shrooms btw.

If I stop taking Prozac a week before the pills, I get a really good roll but it still takes a lot of pills. This seems to confirm the fact that Prozac has a half life of up to 7-9 days, so much of its effects will have started to die down.

The test on rats showed that Prozac had to be taken within 6 hours of the roll. This brings the roll to a crashing end, but 6 hours is good enough! What I do now is take 1 Prozac 6 hours after the roll and wait a week before rolling again.

My next test will be to go a fortnight without Prozac before I roll again, to see if I can get the same effect from fewer pills. Last Friday I got through 7x MDA and 9x dried shroom powder pills in 10 minutes.
 
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Can someone experienced please confirm that taking prozac while rolling will have a direct and detremental effect on the high.

If that is the case, i will start taking my prozac in the morning instead...
 
<If I take even 1 Prozac at the same time as 5 pills, 70% of the roll is lost.
This is exactly what happens if I take Prozac at the same time as shrooms btw.>

Taking Prozac in the morning won't make any difference. If you take Prozac every day it could take up to 45 days until the last bit is out your system. You need to leave it a week at least, preferably a month.
 
i have no intention of postponing my drug therapy just for one good night of rolling...I guess if taking in the morning or after the high at like 5am doesn't make a difference, i'll just have to settle for 70% less rolling...sigh...Last time i rolled on saturday i think it was better than your predictions suggest
 
Not my prediction, just my experience when taking Prozac at the same time as the pills. Reason dictates that something with such a long half-life will not wear off in half a day, but different chemicals react with different people in different ways. For example I am so sensitive to Prozac I get the first affects from it within 12 hours, while its supposed to take 2 weeks from fresh.

Let us know how you get on.
 
I've been taking Prozac (Fluexetine) for over a year, and although my depression is now much better, I still get them prescribed because I read that rats given Prozac after loads of E showed greatly reduced damage to their serotonin receptors...
...
The test on rats showed that Prozac had to be taken within 6 hours of the roll. This brings the roll to a crashing end, but 6 hours is good enough! What I do now is take 1 Prozac 6 hours after the roll and wait a week before rolling again.

You're kinda got the wrong end of the stick with that one. The study showed 6 hours is the longest gap between MDMA and prozac, that you can still detect any neuroprotective effect, i.e. at 6 hours most of the neurotoxicity happens, but a small amount is stopped.

You're much better off taking antioxidants to protect against neurotoxicity.
 
I'm still on Celexa and I decided to try rolling. I took a #1 and snorted 1/3 of another (I don't believe it with the 100% MDA.. i believe it was mild MDMA and MDA combo but maybe MDMA alone. My pupils dilated and I did feel somewhat more happy than usual. I usually pat my hair down while rolling and I was doing that too. I wasn't too talkative, but I did do a lot of yawning tho. If I took more I think I would have rolled harder. My friends said they were seeing stuff move (i.e. looking at the ceiling) but I didn't notice anything.

NOTE: I've been taking Celexa 10mg for about 3 weeks now.
 
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