I doubt this has anything to do with bioavailability, but I've always noticed that caffeinated soda seems to 'bring on' the effects of gabapentin, especially with staggered doses. I usually dose 900mg with a soda, another 900mg twenty five minutes later, and finally a 1200mg dose with more soda an hour and fifteen minutes after the first dose. I'm usually feeling all the effects at +02:30 (sociability, reduced anxiety, shiny surfaces, slight floating sensation, very slight closed-eye imagery) and they usually last for the rest of the day more or less.
When I first started using gabapentin, I would dose around 3000mg at once but I found out that it was a big waste after I started trying the staggered doses. Tolerance builds strong and fast, and at one point I was having diminished effects even up to two weeks after my last dose, but that was still taking one large dose (3000mg or more) at once. Nowadays I'm usually taking gabapentin two to three times a week at up to 6000mg (1800mg, 1800mg twenty five minutes later, 2400mg an hour and fifteen minutes after first dose) using staggered doses and I'm not noticing the diminished effects at all unless I attempt dosing two days in a row.
So, yeah.. If anyone's getting upset about the tolerance issue, I'd definitely try staggered dosing because I can tell you from experience that works a heck of a lot better than taking one massive dose at once. Try some soda, too. Gabapentin's a lot better when you're able to take it when you want to, not just when you -think- it'll work. Peace.
