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MAOIs to enhance recreational drugs?

specialspack said:
Serotonin syndrome is due to an excess of serotoninin the interneuronal space. Excess tryptophan can cause it, but the most common cause is the combination of drugs which block the removal of serotonin from the interneuronal space.

So when you said:


Nope.. if you take a non-selective or MAO-A inhibitor with MDMA, the serotonin will be massively released, and then not broken down -> serotonin syndrome. It won't affect your comedown (if you survive) - the serotonin will all have been released from your neurons and (eventually) depleted. MDMA blocks the re-uptake too, so non will be re-uptaken into the cells.



Again, no. 1. There will still be a post-E serotonin dip as you have excreted a large amount of serotonin by taking MDMA, which has not been re-uptaken.
2. The theory of neurotoxicity caused by the uptake of dopamine into the serotonin neurons has been pretty much discarded - http://thedea.org/neurotoxicity.html#m you're half right though - l-deprynl (selective MAO-B inhibitor at low doses) provides neuroprotection - http://mdma.net/depsave.htm but I'm not sure what the suggested mechanism is now?


That's why I thought you might not really know what you were talking about... MDMA with any strong non-selective or MAO-A inhibitor is potentially fatal, and would provide non of the benefits you suggest. MAO-B inhibitors may provide some neuroprotection, but won't enhance the effects (or at least, the anecdotal evidence seems to be mixed at best).*

As for the meth/4-mar, I really have no idea...

*All this is simply my amateur understanding, if anyone wants to correct anything I've said which is incorrect, please do so. :)
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Well if you inhibit MAO, then you don't need to release as much serotonin as the levels would be naturally higher, and so depletion wouldn't be as significant. Also the serotonin wouldn't be oxidized during/after the E.
 
LMM said:
Well if you inhibit MAO, then you don't need to release as much serotonin as the levels would be naturally higher, and so depletion wouldn't be as significant. Also the serotonin wouldn't be oxidized during/after the E.
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Oh I agree that you don't need to release more Serotonin.

Now, wouldn't it be nice if you were able to dictate just how much serotonin you release?

I don't think MDMA goes, "oh - there's a MAOI at work here, therefore I'll be responsible and not release as much Serotonin as I normally would."

Do you see the point?
 
Old thread but assuming you took a small dose (talking almost nothing like 40mg) of a reversible MAOI (like moclobemide/aurorix) with a dopagenic drug like meth what would happen?

What parts of the high would it increase, would it simply increase the CNS side effects? Or would it increase the dopamine etc as well?

Because if it doesn't even get you anymore high (in a good way) then that alone should stop people asking about combining them, if of course the risk of hypertensive crisis isn't a big enough turn off.

Cheers
 
You seem like your set on doing this, since you already know so much only thing to say is stay extremely low with the doses.
 
Tried it, raised my heart rate and nothing else changed (eg high etc was identical). Took a clonidine to reverse it and yeah, heart rate dropped back down. Moclobemide only has a half life of 1-2 hours so if you were going to use anything I would say it would be the best one to use.

I'm sure if you took more than 40mg (not even 1/8th of a tablet) then who knows, it might raise a fuck load and you could be in trouble. I only did it because I had strong benzos, alpha blockers and anti psychotics on hand. Checked heart rate every 10 mins to gauge what kind of rate it was increasing by. Went from 85bpm to 112bpm in about 15 minutes so yeah, seems risky business especially for no increase in high.

Curious if anyone else has experimented and what their effects were, definitely not encouraging it, just curious about past experiences as it is almost impossible to find anything other than "don't do it", no first hand or hell even second hand experiences to read about.
 
rolls_ said:
Tried it, raised my heart rate and nothing else changed (eg high etc was identical). Took a clonidine to reverse it and yeah, heart rate dropped back down. Moclobemide only has a half life of 1-2 hours so if you were going to use anything I would say it would be the best one to use.

I'm sure if you took more than 40mg (not even 1/8th of a tablet) then who knows, it might raise a fuck load and you could be in trouble. I only did it because I had strong benzos, alpha blockers and anti psychotics on hand. Checked heart rate every 10 mins to gauge what kind of rate it was increasing by. Went from 85bpm to 112bpm in about 15 minutes so yeah, seems risky business especially for no increase in high.

Curious if anyone else has experimented and what their effects were, definitely not encouraging it, just curious about past experiences as it is almost impossible to find anything other than "don't do it", no first hand or hell even second hand experiences to read about.
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there was a whole thread in trip reports about moclobemide and mdma so do a bit of searching and dont be so lazy ;p

there was a lot of descriptions of the high and lots of rowing
 
I did read that but MDMA is a bit different to meth. Thanks though.
 
rolls_ said:
I did read that but MDMA is a bit different to meth. Thanks though.
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to be fair both release serotonin and a lot of dopamine so there's a fair bit of overlap. i'm pretty sure serotonin syndrome is just as bad as a hypertensive crisis. they're both possibly fatal...

try looking up deprenyl and adderall, i'm sure some fools have done it
 
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