• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards

MAOIs and pure cocaine. It's never a GOOD idea. But let's talk about it.

Marauder

Bluelighter
Joined
Sep 6, 2010
Messages
245
Location
Us.. and them.
see http://www.ncbi.nlm.nih.gov/pubmed/3235232
and http://www.ncbi.nlm.nih.gov/pubmed/11245920

and in my IDIOTIC AND DANGEROUS experience using micro doses of coke/crack while titrating up on Parnate (very low doses) I have experienced little to no problems. Taking 3-5 lung fulls of freebase cocaine makes me feel lightheaded and somewhat sick. Again, I have a lot of monoamine oxidase enzymes floating around because I'm taking only 10mg of parnate a day and I'm very careful to wait 10 mins between hits. You should NOT do this because you might die!

Ethylphenidate and Ritalin don't seem to have any problem on MAOIs. Amphetamines do. If you buy any street drug, the CUT in the drug might kill you, if you're on an MAOI! so coke/street pills are never safe on an MAOI. Ignore any "safe combo" maoi-drug interaction charts! They obviously don't apply to the real world less than USP grade shit peddled on the streets.

Any catecolamine releaser (amphetamines, aminorex, u4ea, BZP, meph, methylone, MDMA, 6-apb, etc) in any dose at all on an MAOI is likely to send you to the ER, maybe dead on arrival. It has happened with mdma/amphetamine. So please don't read my post as advice or any proof of concept.

In fact, now that I've titrated up to 15mg a day of parnate (maoi), I will not be touching coke. But this topic is still interesting to me. I know Ritalin should be OK to take because it lacks serotonergic activity. But do other drugs that don't release (but stop reuptake) of serotonin prove possibly lethal with an maoi? why doesn't Ritalin cause a hypointensive crisis? It doesn't release dopa but it blocks the reuptake of it. I suppose it's drug specific. Cocaine as far as I know does not release any serotonin but only builds it up by blocking its reuptake. Perhaps the brain is just more sensitive to serotonin floods compared to the other catecolamines.
 
Top