I think it is relatively safe to say that it is
HIGHLY SUSPECT to rely on the
"literature" of these pharmaceutical companies who produced these classes off drugs for profit, relying on fraud & breaking the law (see source below); & especially given how both eli lilly (manufacturer of pregabalin) & Parke-Davis (manufacturer of gabapentin) got their fucking asses sued off for via results from their initial "studies" saying it's gabapentin is a the WONDER DRUG... CURE ALL.. pregabalin is safe, no dependency issues, excluding any addictive, withdrawal, or suicidal potential.. (which is now
SUPPOSED TO BE explained to any consumers. Well it was NEVER EXPLAINED TO ME.. Doc's need their kick backs, eh?) Guess-fucking-what? They're
illegal off-label promotion of gabapentin & pregabalin cost both companies least ~$2 billion & gabapentin (not sure of pregabalin) has a
black box warning for doctors/pharmacists!! ..here in the US at least. No matter, it is commonly fucking ignored. Again, i'm not solely relying on studies that are
ALL fucking sponsored by legal-dope-dealers.. their activities clearly show they have no intention of creating helpful medications to cure diseases, but merely using pharmaceuticals as a means to make as much profit as possible.
I speak as a recovered/recovering heroin/fentanyl addict (~5yrs clean, 4mg/day buprenorphine); current barbiturate user (Rx for butalbital, 2000mg/day) & current/recent gabapentin user (2400mg/day & increasing, started at 900mg/day),
I AM JUST SAYING- trusting these initial studies are like trusting a goddamn used car salesman w/ your fucking life! The jury is still out on these class of meds. I certainly felt very uncomfortable (even while being on high doses of barbiturates & increased dosages of my usual buprenorphine Rx) when I ran out early of gabapentin. Conversely? I can take roughly ~50%-75% of my typical barbiturate daily dosage & be comfortable if i take 1.5x my gabapentin dose or more (sorry, i know this is about pregabalin, but, they're one-in-the-same, pregabalin is just severely more potent).
I'm JUST SAYING.. don't fucking rely on these greedy fucks ($3.063 BILLION in sales, in ONE YEAR ALONE, 2010) who peddled these classes of drugs without concern for adverse effects, withdrawal, etc--it took myriads of lawsuits, FDA fines, EU fines, & numerous out-of-court settlements for both of these asshole manufactures to finally start noting in their fucking commercials that they're "not for use in persons with history of drug abuse" HINT HINT (OH, can't fucking advertise TOBACCO? But any pharmaceutical? SURE! That ~$3 bill in profits buys a lot of US congressman/women).
Again, we're supposed to abide by & believe the "scientific data" (& i'm not a conspiracy theorist type) produced & performed by researchers, pharmacists, pharmacologists, & other neuropsychiatric scientists all bought & paid for by pfizer (pregabalin manufacturer, fined for bribery & improper promotion for off-label, un-studied effects, referenced below), parke-davis (manufacturer of gabapentin & original producer of pregabalin, but the rights were sold to *
SURPRISE* pfizer! & mind you, parke was fined & sued to hell, as mentioned, nearly half a billion dollars for illegal promotion to doctors for treating ailments. Ailments never even researched for efficacy against placebo at the time), also their shell-pharm-companies, & other for-profit-fuckhead pharmaceutical peddlers who jumped on the cash-wagon via private investing & share-holding (eli lilly being one of 'em- wouldn't trust for a moment given their huge lawsuits regarding SSRI adverse effects they conveniently failed to mention until someone put a gun to their fucking head & pulled the trigger)... SO here ya go:
#1 --
http://onlinelibrary.wiley.com/doi/10.1002/art.20983/full
Dr. Crofford has received consulting fees of less than $10,000 from Cypress Bioscience, Eli Lilly & Co., Orphan Pharmaceuticals, Pfizer, and Wyeth. Dr. Rowbotham has received consulting fees of less than $10,000 from Eli Lilly & Co. and Xenoport, owns stock in Xenoport and Neuromolecular, and was a coinvestigator on a study of gabapentin funded by Pfizer. Dr. Mease has received consulting fees of less than $10,000 from Pfizer, Cypress Bioscience, Eli Lilly & Co., and Pierre Fabre and owns stock in Cypress Bioscience. Dr. Dworkin has served on the advisory board or as a consultant for fees of less than $10,000 for Abbott Laboratories, Alpharma, AstraZeneca Pharmaceuticals, Bristol-Myers Squibb, Elan Pharmaceuticals, Eli Lilly & Co., GlaxoSmithKline, Johnson & Johnson, Merck KGaA, NeurogesX, Inc., Ortho-McNeil Pharmaceutical, and UCB Pharma; has received consulting fees of more than $10,000 from Pfizer, Allergan, Novartis, Epicept, and Endo; and owns stock in NeurogesX, Inc. Ms Corbin, Mr. Young, Ms LaMoreaux, Ms Martin, and Dr. Sharma own stock in Pfizer.
#2 -- Additionally:
http://news.bbc.co.uk/2/hi/business/8234533.stm
US drugmaker Pfizer has agreed to pay $2.3bn (£1.4bn) in the largest healthcare fraud settlement in the history of the Department of Justice...It comes after the firm was found to have illegally promoted four drugs for uses which had not been approved by medical regulators....The civil settlement also relates to allegations that Pfizer paid bribes and offered lavish hospitality to healthcare providers to encourage them to prescribe four of the company's drugs. These [included] Lyrica
(CONT)I just wouldn't trust any goddamn study (which some of you are deducing alleged "facts" from) on the effects of any of these new class of drugs by these legal dope peddlers. Seriously. They may be helpful medications? But, this shit needs to be under government, civic, or populace control, & readily available to those who need it--i.e., single payer or the UK's NHS-type system. Anticonvulsants & antiepileptics are
NOT something to be taken lightly.. they may not act as positive modulators at GABA
A receptor binding-sites, but that in no way-shape-or-form means they're any more safe to go cold turkey from; especially given these class of GABA analog drugs are very new & poorly understood.