Lundbeck files novel antidepressant vortioxetine in EU

sekio

sekio

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Lundbeck files novel antidepressant vortioxetine in EU
PMLive

200px-Lu_AA21004.svg.png

Lundbeck has submitted its antidepressant drug candidate vortioxetine in Europe, raising hopes that it could become the first novel drug treatment for depression to reach the market since 2007.

Vortioxetine (formerly Lu AA21004) is described as a multimodal antidepressant, working as a serotonin 5-HT3 and 5-HT7 receptor antagonist, and 5-HT1b receptor partial agonist, and 5-HT1a receptor agonist and an inhibitor of the serotonin transporter SERT.

The drug is a critical pipeline product for Lundbeck as it tries to find replacements for big-selling antidepressant Lexapro/Cipralex (escitalopram) as well as other products that stand to lose patent protection over the next few years, putting around $1.6bn in revenues at risk of generic competition.
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http://www.pmlive.com/pharma_news/lundbeck_files_novel_antidepressant_vortioxetine_in_eu_426534
http://en.wikipedia.org/wiki/Vortioxetine

Yeah yeah, patent grab, et cetera. And that drug structure does look kinda nasty, I mean, a xylene thiocresol type thing? Count me right out. (Obviously it's been shown it doesn't come popping off, since it's effective for depression with "fewer side effects" than the standards & people aint dying, but...)

The implication of less sexual disruption and more "targeted" activity makes me feel kinda warm and fuzzy. Less of a reason to avoid medication for those who need it but won't use it for fear of permanent sexual dysfunction. (please let's not turn this thread into an "I took Lexapro and now can't get a boner")

Related drugs are apparently triple reuptake inhibitors so maybe there's a way to modify it to make homemade super coke. Haha, not.
 
I wonder where ketamine is in the pipeline and whether we might see it available by prescription within the next decade.

I also would like to see an amphetamine-like antidepressant developed. One that actually makes you feel good. With the added bonus of putting a dent in the western obesity epidemic.

To this day, nothing has been as effective for my depression as Adderall was. I had it prescribed explicitly for depression for like 3 years.
 
Oh now that's bullshit... what they need to do is do like purdue does with oxy and make it time release and then there's a new patent... and ket would be a prime candidate for a time release preparation due to its very short duration....
 
From what I've gathered, the US medical establishment's party line on ketamine is that it's a dirty drug that causes frightening hallucinations, tachycardia, and hypertension, and is grudgingly accepted as a procedural anesthetic exclusively for children, at least until something better is invented.

Sadly, far from seeing its role expanded, I think we'll live to see a day when ketamine is gradually phased out of all medical use, at least in the developed world. I don't see it being made Schedule I unless there's an epidemic of abuse. But I can see a day when anesthesiologists view it the same way infectious disease doctors view chloramphenicol, and nobody keeps it on formulary.
 
They havent phased out morphine or nitrous oxide or even penecillin despite newer and "better" variants becoming available...

Ketamine is on the WHO's list of essectial medications... I don't forsee it disappearing anytime soon..
 
23536 said:
What drug happened in 2007?
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Maybe agomelatine?

In September 2007, Servier submitted a new marketing application for Valdoxan (agomelatine) to the EMEA. On 20 November 2008, Valdoxan was given a positive opinion, with restrictions, by the EMEA, and was subsequently given marketing authorisation in the European Union on 20 February 2009.
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I really wish they would get around to atleast using ketamine for some chronic pain conditions. I have neuropathic pain and bipolar disorder so ketamine could help both the conditions i have. But yeah know it's much better to have me on like 6 different meds for it :!
 
If there were no FDA and everything was available at the drugstore, what chemical would doctors most prescribe for depression?
 
23536, post that as a thread in OD or ADD and see what happens :)

I think it's going to depend on genetics; with low cost gene testing these days it is easy to determine (to some extent) which drugs one would respond to best

Selective drugs like agomelanine, escitalopram, etc are probably higher on the list than "dirty" drugs like the amphetamines and tricyclics
 
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