It will not take two weeks, I assure you, I have done it. The effect of tolerance can ALWAYS be surmounted by an increase in dose. I have taken graduate pharmacology, we learned about tolerance, LSD acts in the same way every other drug does. It agonizes the TAAR1, the same receptor as amphetamine, to cause concurrent Serotonin and Dopamine release verrrry strongly. High doses of LSD, like over 600mcg, is what I usually have taken before. I have always been able to get the good stuff when I wanted to trip. Now, when I have taken 600mcg or above, I have found that I have to take an extra 300-400mcg plus the 600mcg previously dosed. So basically, you can play it safe by doubling it, or if you do not have a lot on handy then it would also be possible to raise it by, at least half. So if you said 300mcg, you could add 150-200mcg, total of 450-500mcg. The higher the dose before, the higher the dose you will have to take again for the same effect. The receptors you have for the drug to bind to are still there, they have just been "temporarily taken away," only some of them though, there are still places for the drug to bind, just less places, so you have to increase the drug amount to compensate for the lesser amount of binding spaces. Just think of it as the receptor is the lock, and Lucy is the key, that one key has to find one lock to fit into, but there are less doors if you have used the day before. I generally can wait a week and get the same effects, as I said, however, that may be because I have always taken large doses in the past when I used to trip.