LSD and RCs Cross tolerance?

[Mr.W]

Hey,
was just curious the cross tolerance between lsd and various rcs. Do DOB, DOC, DOI, 2C-E, 2C-I, etc have any cross tolerance with lsd and mushrooms?

Thanks for any input.

 

[drewmandan]

Someone may correct me, but my understanding is that tolerance is caused by down-regulation of the affected serotonin receptors, and all these guys you listed affect basically the same receptors. So yes, there should be some cross-tolerance. Although, it may not be 100% cross-tolerance as these drugs don't affect the receptors in precisely the same ratios.

 

[any major dude]

I'm not sure if theres a clearly understood physiological reason for it, but most people, myself included, seem to experience cross tolerance between almost all serotoneric psychedelics. I've read an odd case here and there about people not experiencing this with 2c-x's, but those are very rare exceptions if that info is even reliable.

 

[Delsyd]

Someone may correct me, but my understanding is that tolerance is caused by down-regulation of the affected serotonin receptors, and all these guys you listed affect basically the same receptors. So yes, there should be some cross-tolerance. Although, it may not be 100% cross-tolerance as these drugs don't affect the receptors in precisely the same ratios.

thats my understanding aswell.

 

[Mjäll]

I'm not sure if theres a clearly understood physiological reason for it, but most people, myself included, seem to experience cross tolerance between almost all serotoneric psychedelics. I've read an odd case here and there about people not experiencing this with 2c-x's, but those are very rare exceptions if that info is even reliable.

According to my limited experience (first- and second-hand), 2C-B doesn't leave tolerance. This is pretty strange since the mechanism of action is basically the same as with the tolerance producing tryptamines and ergotamines...

 

[McTwist]

5mg of 2c-i and 5mg of 2c-e had no noticeable effect on 2 hits of LSD the next night. My friend took 18mg of 2c-i and also reported no cross-tolerance. I'm sure it's there, but it's not very apparent with the 2c's

 

[greenmeanies]

for me and 2c-e, tolerance does not really appear the next day. I was able to take 4mg rectally (++) once a day for three consecutive days with no noticeable reduction in effects. after a week however, both the positive (visual) and negative (nausea) effects seemed diminished, requiring a higher dose for the same effect. the ratio of positive to negative also seemed to shift towards more negative.

i have not yet tried LSD or shrooms the day after 2c-x, but I would guess that as long as your 2c dose was reasonable and you got some sleep after your first trip, then LSD would have a fairly normal effect (that is, if LSD's effects can be called 'normal')

 

[Oh1o0hwhyO]

I don't have any concrete info, just what was already stated, but this weekend ill be at a fest, taking 2c-e on friday and either 4-aco-dmt or lsd on saturday. ill give you a solid report of the tolerance that occurs (or doesn't) when i get back from it.

 

[TheAzo]

There are plenty of examples of things that effect the same receptors but cause tolerance to develop at different rates - some might be explained by the different binding mode, others by black-biological-magic.

Ex:
Fentanyl-derivitives build tolerance faster than morphine-derivitives.
JWH-xxx's build tolerance faster than weed, and CP-55,940 faster still.

I wonder if the important thing is partial vs full agonist, even assuming the same level of effects (more receptors occupied but less activated vs few receptors highly activated)? I recall seeing a list of the maximal activation of 2C-X's compared to other psychedelics, and it was lower for the phens... The obvious test of this simplistic theory is seeing whether DOx's (assuming they actually are full/stronger agonists) produce rapid tolerance like tryptamines do.