LSD and MDMA mix mess up

[danielf123]

well a few weeks ago a friend of mine wanted to try Acid for the first time
we were at an event and she had rolled at this event and i had taken 2 hits of some good acid and i had 1 left, they all came from the same sheet cuz when i got them, they were all connected

so in the car ride home, her boyfriend convinces me to let her have it in exchange for his last pill so i say okay fuck it, why not.
She took it in the car on the way home but she was coming down off the pill already

later on i went home n all but i asked the next day what happened with her trip
they said she didnt even trip at all, she never even felt the acid

its our simple speculation that maybe she didnt trip cuz she had just came down of the MDMA....but we dont know why she didnt
i dont think the acid "died" cuz i had only been holding on to that last tab about an hour or 2 after i took my 2

any ideas?

 

[any major dude]

Unless it got excessively hot or wet nothing should've happened. I suppose someone could've fucked up when laying the blotter & not gotten a dose on that hit somehow...

MDMA doesn't have a cross tolerance with LSD, so that shouldn't have caused a problem. Is she on any anti-depressants or sedatives etc?

 

[caseface99]

^^ I agree. I have gotten a sheet before that clearly had the acid put onto it with a dropper rather than laying it correctly. You could vaguely see spots where the acid had been dropped on in rows on the back, but they weren't overlapping so there was acid-less blotter in between. It wasn't just what the blotter looked like because some of the tabs were 'ok' and some of them had little to nothing. I had to eat 5 to considering myself tripping, before that i was just sort of "high". Even so it was a pretty weak trip, so obviously i was pissed about the quality of the sheet. It wasn't that bad for me because i had been picking it up for a friend, but i still felt bad giving him such shitty tabs.


Either way though, OPS tabs could have come from a similarly laid sheet, except higher quality where it was layed at least.

 

[strawberry jam]

Although the two drugs work differently, from personal experience, I think there might be some cross tolerance. I once took MDMA at a music festival and then tried tripping the following afternoon on 1 1/2 tabs -- I felt something, but it was very, very weak for the quality of the tabs (I took 1 1/2 a month later from the same batch and had a very different, intense trip). Maybe the complete lack of serotonin and exhaustion from rolling made her unable to feel the acid.

 

[solistus]

The two definitely interact. When taken together, they potentiate one another a great deal - the legendary candyflip. I've heard reports similar to this that dosing *after* a roll tends not to work very well. LSD operates via serotonin receptors, and MDMA produces a short-term flood of serotonin resulting in depleted serotonin levels after the experience, so it makes sense on an intuitive level that it would be harder to trip right after coming down from a roll.

Or, maybe it was just a very low dose. She's never tried acid before, took only a single tab and this was after a night of rolling. If she was expecting a dramatic +++ trip and got only a weak + or ++, she may not have noticed the effects at all.

 

[danielf123]

The two definitely interact. When taken together, they potentiate one another a great deal - the legendary candyflip. I've heard reports similar to this that dosing *after* a roll tends not to work very well. LSD operates via serotonin receptors, and MDMA produces a short-term flood of serotonin resulting in depleted serotonin levels after the experience, so it makes sense on an intuitive level that it would be harder to trip right after coming down from a roll.

Or, maybe it was just a very low dose. She's never tried acid before, took only a single tab and this was after a night of rolling. If she was expecting a dramatic +++ trip and got only a weak + or ++, she may not have noticed the effects at all.

the first part is exactly what we thought
since they both operate via seratonin, that flood of seratonin is what made it hard for her to trip

n yeah, i took 2 hits and tripped hard!!!! maybe she was expecting to trip like me, but also never know about ow they said that it got layed wrong or something.

 

[grimmo]

Hmm yeah I remember getting different results from blotter tabs from the same sheet. I had a sheet stored wrapped up and in a fridge and as time went on all seemed ok then the last quarter we're duff. . Except one I had that was very very strong. Perhaps bad laying?

 

[psilocybonaut]

Hmm yeah I remember getting different results from blotter tabs from the same sheet. I had a sheet stored wrapped up and in a fridge and as time went on all seemed ok then the last quarter we're duff. . Except one I had that was very very strong. Perhaps bad laying?

Yeah, must have been uneven laying.

If they were BUNK, the page/sheet was definitely not laid correctly. Someone could have used the dropper method or the "spray bottle" method (I have seen someone do this, seemed completely inefficient).

Proper blotter is laid in a pan that is filled with potent liquid LSD solution. The whole 900-hit page of watercolor paper must be completely submerged in the liquid so that it can soak it up properly. I have heard that SOMETIMES when the blotter is hung up to dry, the corner hits which were on the bottom when drying can sometimes be very, very strong. But if 25 hits were completely bunk, someone doesn't know how to lay blotter.

P.S. Was it in an airtight glass container? If not moisture possibly could have contributed to (possible) degradation...

 

[any major dude]

some people are idiots... i dunno why anyone would try to dose blotter paper with a dropper, that's just moronic. I'd guess that would be what happened.

And while MDMA & LSD do both have serotonergic effects, they are drastically different. MDMA affects SERT & causes release and reuptake inhibition of 5-HT, whereas LSD is a partial agonist at 5-HT2a and several other serotonin receptors (as well as a smattering of other receptor types). The drug binding to those receptors results (IMHO) in some wacky neuromodulation that causes a subjective psychedelic experience.

There may be some affinity for 5-HT2a with MDMA, but if any its small and shouldn't cause much if any cross tolerance. MDMA may cause some receptor downregulation, and I suppose that might cause some decreased effect from LSD, but I don't know for sure.

 

[danielf123]

Yeah, must have been uneven laying.

If they were BUNK, the page/sheet was definitely not laid correctly. Someone could have used the dropper method or the "spray bottle" method (I have seen someone do this, seemed completely inefficient).

Proper blotter is laid in a pan that is filled with potent liquid LSD solution. The whole 900-hit page of watercolor paper must be completely submerged in the liquid so that it can soak it up properly. I have heard that SOMETIMES when the blotter is hung up to dry, the corner hits which were on the bottom when drying can sometimes be very, very strong. But if 25 hits were completely bunk, someone doesn't know how to lay blotter.

P.S. Was it in an airtight glass container? If not moisture possibly could have contributed to (possible) degradation...

the hits were individually wrapped in tinfoil and he had em in a a dark airtight plastic container

 

[danielf123]

idk maybe it was just some freak occurance
other people got acid from him too and tripped hard

she was the only one who didnt

 

[Shambles]

some people are idiots... i dunno why anyone would try to dose blotter paper with a dropper, that's just moronic. I'd guess that would be what happened

Have seen it done many times. Some folks are just kinda low-tech in the extreme :D

Definitely more room for big variance in dose from one part of the sheet to another and seems more likely than such extreme acute cross-tolerance to MDMA. Even after way too much MDMA I can still squeeze a trip out of me fried synapses before beddy-byes if I really feel the need.

 

[aussieblues]

This has probably already been mentioned, but I'll just recap.
LSD works primarily on serotonin receptors, MDMA releases serotonin.
Therefore, it would make sense that after rolling, when serotonin levels are at their lowest, it would be difficult for another chemical that works on the serotonin receptors to have much effect.
It could also be a matter of having poorly laid blotter.
Either way, bummer for your friend. You should've kept it for yourself!