I get the feeling you're looking for someone to say, "DO IT!!!!!!!!" But yo, save it for a day which the last thing you have to worry about, is work. A glass of quality shiraz with lunch, while hiking, might tickle you the right way, though.
I like to take LSA when I don't have any work to accomplish the day of the trip. I like to be able to enjoy it and not have to worry about doing physical labor. While I'm tripping on LSA I sometimes get a bit nauseous when I move around too much, so I think going to work would be a pretty bad idea. My pupils also get extremely dilated and I cant stop smiling for life me. People would definitely know i was under the influence of something. It's a such a beautiful and euphoric experience that I wouldn't want to waste it in anything but a perfect set and setting. Being in a workplace environment would most likely get very overwhelming and uncomfortable