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Loperamide Insufflation

I have prepared loperamide for snorting using a cold alcohol extraction. It did NOT get me high, it BURNED LIKE HELL, it was NOT worth it. Very unpleasant.

I can take 50 mg of loperamide (25 of the little blue 2 mg pills of course) with absolutely zero problem getting clogged up. Sure, I don't shit for 24 hours after that, but its not a problem at all.

At the 50 mg dose, as I've described before here on BL, I get the 'rubber leg' and 'empty stomach' feeling, the same kind of feeling I get from a smallish dose of morphine. There are DEFINITELY opiate-like effects from loperamide. I have never gotten actually high from loperamide by itself, but it has potentiated poppy pods quite well.

It also helps with withdrawals. If I am going through medium withdrawals, I take 5 loperamide tablets (the 2 mg ones) every 15 minutes until I have taken 50 mg. It somehow works better to taper up to a good dose instead of taking it all at once. I can just about feel normal with loperamide if I am withdrawing. It is a great benefit at higher doses... 50 mg is my minimum dose for getting rid of withdrawals.

Maybe you can get high on doses higher than 50 mg. I personally have never taken above 65 mg. I've never had any stomach problems or ill feelings from loperamide at all.

antbanks99 said:
Wish I had an "end thread" button, this thread is pretty much useless......
Click to expand...

i for one am glad you don't.

however, you do have a 'don't look at thread' option. it's built right into your own brain. no button required.
 
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Ok, to add more to the discussion:

three days ago I took 12mg of loperamide, I couldn't tell for sure if I had a slight opiate buzz going on or if it was just placebo, but what WAS obvious was the feeling of my stomach and intestines knotting up for ... oh ... three fucking days. I just shit 4 minutes ago. I can't even imagine taking more than 12mg.

It's not worth it, stay the fuck away unless you have opiate withdrawals or have found a worthwhile way to get it to cross the BBB (I'll admit I haven't snorted it yet)



*Edit*

LoL:
image1cc9.jpg


Happy 666'th!!
 
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ok, apparently it has very adverse effects on different people, stomach-wise. i personally have probably permanently transformed my intestines so that i'll never get clogged again by any opiate (i haven't been constipated in a couple of years and use opiates almost constantly).

do you have a high tolerance pcchip, or are you a regular opiate user? it would be helpful to know why some people get the 'knotted up stomach' thing off of what, IMO, is a relatively low dose.

oh... and it should be obvious to anybody with zero opiate experience or tolerance NOT to take huge doses of lope like i and others have suggested. i do remember the days before i ever touched a pain pill or any type of opiate, one dose of lope would clog me up good. i think all of this experimentation with lope in high doses should definitely be left to addicts ;)
 
I was coming off of 100mg per day habit of Hydrocodone for 2-3 months, I'd call that "medium" or so I suppose
 
klowns said:
but you also have to understand, there really is NOT a lot, or barely any info about this anywhere. i know its been discussed before, but not very in depth,
Click to expand...



^ To the OP and everyone who thinks I was I was just being a dick for no reason at all. 8)

UTFSE this topic has been covered more times than the Paris Hilton story on the news
 
those are just threads that have the word loperamide in it. none of them talk about nanoparticles! thanks to the guys who stuck up for me
 
Not that anyone cares, but I tried taking a high dose a while back and it did give a long-lasting vicodinish buzz- BUT!!!- mind the godawful, excrutiating stomach cramps that ruin the whole time. Not worth the pain&suffering IMHO.
 
PcChip said:
LoL:
image1cc9.jpg


Happy 666'th!!
Click to expand...

LOL... holy crap =D thanks

edit:

enoughorangejuice? said:
To the OP and everyone who thinks I was I was just being a dick for no reason at all. 8)

UTFSE this topic has been covered more times than the Paris Hilton story on the news
Click to expand...

some people are interested in this topic and no mods have come in here bitching, so quit being a 'memberator' and lay off for crissake, nobody is forcing you to participate in this thread.
 
So far all that I've read on liperwhateverthefucki'dnevertakeit does not go into great detail about the chemical structure....he's asking for specifics and so far he hasn't got his answer...just chill and maybe someone will come along with a pharmaceutical degree. Obviously none of us have one....
 
I don't get it. Most drugs have already been discussed exhaustively on bluelight. Should the discussions stop then? Why single out loperamide? Why not complain about the thousands of threads about crack, oxycodone, SSRIs, etc? There's almost always something new being added to a repeated discussion, so if it doesn't interest someone, they simply don't click on the thread. It's not like loperamide discussions are flooding the forum and causing trouble.

Anyway.. about the nanoparticles. It does work to get the drug into the brain. So does coadministration with Cereport, a BBB permeabilizer. But are those options practical to anyone here?

1: Eksp Klin Farmakol. 1998 Jan-Feb;61(1):17-20.

[The delivery of loperamide to the brain by using polybutyl cyanoacrylate
nanoparticles]

[Article in Russian]

Aliautdin RN, Petrov VE, Langer K, Berthold A, Kreuter J, Kharkevich DA.

Department of Pharmacology, Sechenov Medical Academy, Moscow, Russia.

The possibility of using polysorbate 80-coated nanoparticles for the delivery of
the water insoluble opioid (lyonist loperamide across the blood-brain barrier was
investigated. The analgesic effect after i.v. injection of the preparations was
used as the indication of drug transport through this barrier. Intravenous
injection of the particulate formulation resulted in a long and significant
analgesic effect. A polysorbate 80 loperamide solution induced a much less
pronounced and very short analgesia. Uncoated nanoparticles loaded with
loperamide were unable to produce analgesia. Polysorbate 80-coated PBCA
nanoparticles loaded with loperamide led to the transport of loperamide to the
brain.
Click to expand...

One more thing.. there are peripheral opioid receptors in the body, so it shouldn't be much of a surprise if taking loperamide makes you feel physically different. It was even shown to have analgesic effects on rats.
 
What about cooking it up in some acetic anhydride/acetic acid? Just a thought.
 
About the nanoparticle guy, I actually thought you were being sarcastic. Nevermind, I'm glad you are contributing to the question at hand.

And thank you everyone who actually kept this thread going, I was just wondering about the actual opiate attributes of loperimide.
 
enoughorangejuice? said:
ugh please no, why did i click this. god save me, not another 14 page thread about 1 or 2 people saying taking like 350mg of immodium AD gets you high and like 73 people say its fucking retarded and will just rape your stomach and you won't shit for a month and flame the shit out of that one guy who really loves immodium like more than psychoactive drugs like oxycodone or heroin, etc. his fucking BL screen name is something like "loper=a=mind" the guy loves it, can't wait til he gets here and starts ranting on how great it is, this should be fun to watch i'm not gonna say anything, just gonna sit back and watch the fighting and fun.

but i guess i've already said a decent amount. oh well.

IMMODIUM IS A FUCKING ANTI-DIARHHEA MEDICINE, YOU CAN'T GET HIGH ON IT, NUTMEG IS A BETTER DRUG.

i'm going insane, can't take anymore threads on immodium, xanax/benzo insuffilation, shooting percocets/vicodin, sniffing percs or vics, etc
Click to expand...
I was laughing before I clicked it. Just watch it play out and enjoy!
 
malfunkshun said:
ok, apparently it has very adverse effects on different people, stomach-wise. i personally have probably permanently transformed my intestines so that i'll never get clogged again by any opiate (i haven't been constipated in a couple of years and use opiates almost constantly).

do you have a high tolerance pcchip, or are you a regular opiate user? it would be helpful to know why some people get the 'knotted up stomach' thing off of what, IMO, is a relatively low dose.

oh... and it should be obvious to anybody with zero opiate experience or tolerance NOT to take huge doses of lope like i and others have suggested. i do remember the days before i ever touched a pain pill or any type of opiate, one dose of lope would clog me up good. i think all of this experimentation with lope in high doses should definitely be left to addicts ;)
Click to expand...

Before I started taking opiates daily (7 years ago), loperimide knotted up my insides so badly I vowed never to take it again. Since opiate use, loperimide makes me relax if I do not take my regular dose of morphine. I can go with out my 60 mg daily morphine if I take 6 large doses of loperimide daily. (Hint: start the loperimide the day BEFORE you stop opiates so your system is saturated when you are out of meds.)
 
Don't fucking snort the stuff. Seriously I'm not one to jump on anyone for asking a question, but what the fuck are you thinking Private Pyle? Its an anti-diarrheal medicine...ya let's snort it dude...we snort everything else right? crack, coke, muscle relaxers, hell ya! remember that one time we snorted a BC powder and it felt like our nose caught on fire....FUCKING AWESOME DUDE!

Anyways, can we please end this thread IMMEDIATELY!
 
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