• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Loperamide (Immodium) Megathread: We have now lost at least 2 of our own from Lope

Status
Not open for further replies.
I've been maintaining at a dose of 300-400mg [never more] every 2-3 days for a year now, holds me psychologically and physically.

Note that it, for me, blockades any other opioid. My tolerance seemed to stop building a year ago. I've been doing this for 2 years.

I use a normal dose of the stool softener Miralax to counter any constipation. In fact... if I use Miralax daily I'll actually get, yes I know TMI, too loose.. even taking all that lope.

I know it could injure me longterm, with parkinson's being batted about by a possible metabolite -- but not yet determined (this metabolite) to cause parkinson's.

I will say that you MUST hydrate a lot if you take high doses of this.

Is it as euphoric as oxycodone or pods et al? No, but I have access to any opioid I want and am not tempted to buy any due to their bloated pricing thanks to the controlled substance act.

I am grateful this exists as an FDA GRAS drug, and sold in bulk, and I can transport it in a car trip in mass quantity without fear. But I know its not all Eden, I know this isnt healthy. But it allows me to function.

I use MDPV to counter sedation because, call me crazy, I actually hate nodding. Why MDPV? Because thanks to the news media its cheaper than dirt, unlike amphetamines. Anyway.. this is just my experience I dont endorse it as a good idea or anything. Do your own research dont take my word etc etc.

Also... I know this doesnt make sense if it crosses BBB, but this is ineffective for analgesia, for me.
 
^^ mate i think youre clear on the parkinsons...

people have been using loperamide regularly for a very long time. i realize only recently (10-15 years, probably more) has it been used in higher doses. either way, there hasnt been a single case of a parkinsons related issues that i have come across. nonetheless, it is good to know you have been doing your research!

it seems the consensus is that loperamide is not broken down into the dangerous metabolite you are speaking of. a *portion* of the loperamide structure is *somewhat* similar to what we're speaking of, but nothing has surfaced since loperamides introduction decades ago, at least not that i am aware of.

what always interested me was the mechanism behind its powerful dehydration property. my guess is that it affects ADH in a way similar to ethanol.
 
After reading up on Loperamide for years, I decided to take the plunge tonight, being out of opiates (but not in w/d) and in pain.

I'm a 27 year old male, 250lb, light to moderate opiate tolerance currently (for reference, 30mg Hydrocodone is my usual dose. Anything much under 20mg, I get zero effect from).

Dosed 48 2mg CVS brand Loperamide gelcaps for a total of 96mg - swallowed them with a bottle of red grapefruit juice (from concentrate - white wasn't available and I didn't particularly feel like juicing any)

At T+0:30, I was already noticing a quite pronounced variation from baseline. This startled me because I wasn't expecting any effect, especially such a strong effect so fast. One of the first effects I noticed was that my peripheral vision was extremely blurred, more pronounced in one eye than the other. At ~1:30 in currently, I'm very sedated, warm, euphoric, and have slight stomach cramping as well. Pupils are extremely constricted, eyelids are really droopy - more-so than weed would cause. I'm also extremely relaxed, and am still very noticeably coming up. My face has been warm for a while, almost like a Niacin flush. This feels EXTREMELY similar to poppy tea for me - heavy body load, more sedating than uplifting. Nothing at all like my personal favorite, Hydrocodone. Approximately a 40-50% reduction in pain.

So far, it's enjoyable, but not something I could see repeating often. The sedation is too heavy for me - I prefer upbeat opiates.

After I dosed, I came across a study claiming with a dose of 60mg Loperamide, 50% of the subjects reported some effect but liked it little or not at all. I can see why, but I am enjoying this.


I'm very experienced with opiates, and have tried most, save for heroin and needle administration. On top of the poppy tea feeling, I find Loperamide to also be reminding me of Butorphanol to some extent.


I feel like a jackass posting this because my expectations were amazingly low. I felt there would be little-to-no effect, and would have given one this pronounced a 0% chance.
 
Last edited:
I've attempted this quite a few times and from my own personal experience, it does work for me if I take at CY450 inhibitor, a high dosage of loperamide and 3 glasses of Grapefruit juice. I've taken in when I wasn't in withdrawal, and it definitely did work. I took 72 mg of loperamide with 600 mg of Cimetidine (a CY450 inhibitor, you can buy it at your local walgreen's or CVS, the brand name known as Tagamet), and 3 glasses of freshly squeezed grapefruit juice (i used a juicer to make the real thing). Take care to take the Cimetidine and drink the glasses of grapefruit juice about 30-45 minutes before you take the loperamide to ensure your CY450 is being inhibited. These conditions allow certain concentrations of the loperamide to cross into the BBB. It definitely feels like poppy pod tea.. maybe a little less. Loperamide is an odd high.. at times it can feel very intense like morphine and at other times very weak like propoxyphene. One thing I did like was the duration; the effects lasted around 7-10 hours for me. Just my 2 cents :P
 
Studies have shown quinine causes higher peak plasma concentrations of lope. Rxlist, I believe, has an article. Interesting read. I know personally it just about completely eliminates WD's for myself. Never tried it on its own.
 
ive done it, i did the usual, tagment and gfj before taking a bunch of lope, maybe 20 2mg pills, i did get high, but the only thing is, that it took about 3x as long to kick in than regular opiates so about an hour and a half, maybe 2 hours later i realized i was feeling up there and it did last longer i have no reason to lie
 
really wish this worked for me, bought 2; 200 count bottles from amazon for like 10 bucks a few months ago and I take upwards of 80mg everytime I've attempted to keep withdrawals at bay with this stuff but it never does anything other than plug me up and make me tired. ughlife
 
tried it again, after posting this because i liked it before, i did the gfj and took 54mg lope, didnt get any effects this time. however im not in WD mode like i was last time i did it.
 
All i can say is i was so sick for some relief and the lope gave me some. It wasnt a "high" really, like most people are saying. It just makes you feel a little better. Its hard to explain. But there is something going on there for sure. Its most definitely not a placebo. I feel well almost right now no joke lol.

I took 96mg of lope and 3,000mg of the tagamet. Then about 2 hours into it i felt something. Then my stomach started to hurt kinda bad actually. Just chug a shit load of pepto and you will be good. After the pepto my tummy settled nicely. Then it seem like the pepto boosted it for some reason and it started to really kick in then. Then about an hour later im feeling ok which a lot better than before lol. Then about another hour later im feeling not too bad, its like im almost well which will make sense to the addicts here.

So in conclusion its something to sooth W/D for sure and can see why people have been going on about it. Its real and it works. If its a placebo its a damn strong placebo lol cause i was sick as fuck just like 4 hours ago. There is something going on with the lope for sure. I kinda dont see it being recreational as its not much of a high really. Maybe if you took some ungodly amount and took all the sups too. But at that point its not worth it. You might as well go get your DOC/FIX whatever. Basically i think that is pointless and its only use is for W/D. Although, i suppose someone with a low tolerance not in W/D could possibly get some kind of "high" at the 100mg mark......maybe.

Oh and one more thing to add. I was also very skeptical of this. But i was so desperate for some relief i didnt care. Also i dont think its a good idea to be doing this all the time. Eventually, if you are and addict you will have to face your addiction. It sucks but it seems to be the only way. Also iv heard of people getting hooked on lope from taking it for W/D for so long. Then they cant stop taking the lope. Just switch addictions. Lope should be used as a tool to get off opiates with minimal W/D symptoms. If not it will become like methadone and subs. People just get hooked on those after. So thats all i gotta say about that!
 
Last edited:
RiseFromRuin said:
why on earth would they market an OTC opiod that might have the potential to become recreational with some at home do it yourself chemistry?

Why on earth would they market (pseudo)ephedrine as a dietary supplement, when it might have the potential to become brain destroying with some bathtub do it yourself chemistry.
Click to expand...

LOL exactly right. Thats exactly why. Basically he means if they will put a precursor for meth OTC then why not an opiate that can have some light effects if taken in large doses with other things to supplement it. It makes total sense that they would make it OTC lol.
 
Last edited:
erosion said:
It doesn't cross the bbb, but ive seen much anecdotal evidence that it has effect. There could be some sort of periphral effect... Who knows. Hows drugs effect the brain and body aren't fully known, and there could be some mechanism that causes action indirectly. Claims about it should be taken with a grain of salt, but shouldn't be discounted entirely.
Click to expand...

Very well said. But, it seems there are so many in here that are brain chemists that know things about how the human brain works with the body in ways that NO ONE else knows about lol. Really though, there are mysteries of how the brain really works till this day. So i think all the experts should keep an open mind, that is all.
 
Last edited:
http://www.ncbi.nlm.nih.gov/pubmed/11804622

Thought you guys might like to see this. It first demonstrates that Loperamide certainly does have analgesic effects in rats. It also concludes that peripherally restricted opiods have potential treatment uses for pain.

On a side note, I've been using high-dose loperamide for my OC withdrawals, and It works wonderfully. It's a damn miracle. In fact I prefer it over bupe. The only downside is that it takes quite some time for it to build up in your system enough to fully destroy withdrawals.

Edit:
[http://www.niscair.res.in/scienceco...May 2005/IJEB-vol 43-May 2005-pp 425-429.htm]

Another very interesting study. When loperamide is introduced directly into the cerebrospinal fluid, it is a far more potent analgesic when compared to morphine introduced in the same manner. This further demonstrates how very powerful loperamide is. So it is no small wonder how effective it is when high doses are used with a tiny fraction likely permeating the BBB. Also, oral coadministration of loperamide with cereport allowed complete passage of it into the BBB, producing significant analgesia. Here is an interesting study on cereport: http://www.ncbi.nlm.nih.gov/pubmed/10496650
Unlike p-glycoprotein inhibitors such as quinidine and piperidine, which prevent the transport of drugs out of the brain, cereport seems to actually increase the brain's permeability overall. Anybody know where to get this stuff, and is it safe to mess with?
 
Last edited:
This post has really got me thinking about how all you guys/girls are and excuse my language; pussyfooting around. CWE might work, but it also might be something else like ISO. I'm going to try them both tomorrow. WHen Its done I will insulffate and if that works we'll go from there.

Let me know if you have any advice.
 
Thizalien, this has been done quite a bit with limited success. I'm guessing lope has piss-poor intranasal bioavailability. Do a google search for loperamide insufflation and you will find several threads about it. But good luck on it! Let us know how it goes.

Anybody have any ideas on how to increase lopes BA intranasally, or even rectally?
 
Last edited:
make some PEG nanoparticles with the sekio labs home PEG nanoparticle kit for making weapons grade narcotics in your kitchen

seiously though, loperamide is purposefully designed to have low absorbtion and not much is going to change that. even if you increase bioavailibility, not much is going to make it into the brain...
 
Does NOT work to get an Opiate high. Popped 20 2mg about 2 hours ago. Nothing but disappointment.
 
Can you REALLY get an opiate high off loperamide (Imodium)?!
If anything I imagine you will RUIN your insides. Loperamide is a very potent anti-diarrhea medication. One time I took 8mg in one evening (following the directions; I had severe diarrhea) and went from spraying blood shrapnel every 5 minutes to being unable to shit for like 4 days.

I also heard it knocks opiates off the um (sorry, I don't know the technical terms) things on your intestinal wall the absorb opiates and allow them into your bloodstream, and that's why loperamide is excellent for opiate withdrawal but will also block your opiates from working for several days after (if you take massive doses of the loperamide, I mean)?
 
MsPilly said:
Does NOT work to get an Opiate high. Popped 20 2mg about 2 hours ago. Nothing but disappointment.
Click to expand...

you need other things to go with it to get it to cross the bbb such as tonic water and grapefruit juice. I've never gotten high on it but its helped a little for withdrawals
 
I took something like 24 mg of lope and nothing else in full wd mode, to me its a life saver. Im not that heavy of a user tho 60 to 80 mg of hydro a day.
 
Status
Not open for further replies.
Top